Summary | |
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Symbol | INSL6 |
Name | insulin-like 6 |
Aliases | relaxin/insulin-like factor 1; insulin-like peptide 6; Insulin-like peptide INSL6 |
Chromosomal Location | 9p24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted |
Domain |
PF00049 Insulin/IGF/Relaxin family |
Function |
May have a role in sperm development and fertilization. |
Biological Process |
GO:0007281 germ cell development GO:0007283 spermatogenesis GO:0007286 spermatid development GO:0007548 sex differentiation GO:0008406 gonad development GO:0008584 male gonad development GO:0009566 fertilization GO:0022412 cellular process involved in reproduction in multicellular organism GO:0030317 flagellated sperm motility GO:0045137 development of primary sexual characteristics GO:0046546 development of primary male sexual characteristics GO:0046661 male sex differentiation GO:0048232 male gamete generation GO:0048515 spermatid differentiation GO:0048608 reproductive structure development GO:0061458 reproductive system development GO:0097722 sperm motility |
Molecular Function |
GO:0005179 hormone activity |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | INSL6 |
Name | insulin-like 6 |
Aliases | relaxin/insulin-like factor 1; insulin-like peptide 6; Insulin-like peptide INSL6 |
Chromosomal Location | 9p24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between INSL6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | INSL6 |
Name | insulin-like 6 |
Aliases | relaxin/insulin-like factor 1; insulin-like peptide 6; Insulin-like peptide INSL6 |
Chromosomal Location | 9p24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of INSL6 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | INSL6 |
Name | insulin-like 6 |
Aliases | relaxin/insulin-like factor 1; insulin-like peptide 6; Insulin-like peptide INSL6 |
Chromosomal Location | 9p24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of INSL6 in various data sets.
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Points in the above scatter plot represent the mutation difference of INSL6 in various data sets.
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Summary | |
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Symbol | INSL6 |
Name | insulin-like 6 |
Aliases | relaxin/insulin-like factor 1; insulin-like peptide 6; Insulin-like peptide INSL6 |
Chromosomal Location | 9p24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of INSL6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | INSL6 |
Name | insulin-like 6 |
Aliases | relaxin/insulin-like factor 1; insulin-like peptide 6; Insulin-like peptide INSL6 |
Chromosomal Location | 9p24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of INSL6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by INSL6. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | INSL6 |
Name | insulin-like 6 |
Aliases | relaxin/insulin-like factor 1; insulin-like peptide 6; Insulin-like peptide INSL6 |
Chromosomal Location | 9p24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of INSL6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | INSL6 |
Name | insulin-like 6 |
Aliases | relaxin/insulin-like factor 1; insulin-like peptide 6; Insulin-like peptide INSL6 |
Chromosomal Location | 9p24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of INSL6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | INSL6 |
Name | insulin-like 6 |
Aliases | relaxin/insulin-like factor 1; insulin-like peptide 6; Insulin-like peptide INSL6 |
Chromosomal Location | 9p24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between INSL6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |