Summary | |
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Symbol | INTS10 |
Name | integrator complex subunit 10 |
Aliases | FLJ10569; INT10; C8orf35; chromosome 8 open reading frame 35 |
Chromosomal Location | 8p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain | - |
Function |
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex (PubMed:23904267). |
Biological Process |
GO:0009301 snRNA transcription GO:0016073 snRNA metabolic process GO:0016180 snRNA processing GO:0034470 ncRNA processing GO:0042795 snRNA transcription from RNA polymerase II promoter GO:0098781 ncRNA transcription |
Molecular Function | - |
Cellular Component |
GO:0000428 DNA-directed RNA polymerase complex GO:0016591 DNA-directed RNA polymerase II, holoenzyme GO:0030880 RNA polymerase complex GO:0032039 integrator complex GO:0055029 nuclear DNA-directed RNA polymerase complex GO:0061695 transferase complex, transferring phosphorus-containing groups |
KEGG | - |
Reactome |
R-HSA-74160: Gene Expression R-HSA-6807505: RNA polymerase II transcribes snRNA genes |
Summary | |
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Symbol | INTS10 |
Name | integrator complex subunit 10 |
Aliases | FLJ10569; INT10; C8orf35; chromosome 8 open reading frame 35 |
Chromosomal Location | 8p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between INTS10 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | INTS10 |
Name | integrator complex subunit 10 |
Aliases | FLJ10569; INT10; C8orf35; chromosome 8 open reading frame 35 |
Chromosomal Location | 8p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of INTS10 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | INTS10 |
Name | integrator complex subunit 10 |
Aliases | FLJ10569; INT10; C8orf35; chromosome 8 open reading frame 35 |
Chromosomal Location | 8p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of INTS10 in various data sets.
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Points in the above scatter plot represent the mutation difference of INTS10 in various data sets.
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Summary | |
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Symbol | INTS10 |
Name | integrator complex subunit 10 |
Aliases | FLJ10569; INT10; C8orf35; chromosome 8 open reading frame 35 |
Chromosomal Location | 8p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of INTS10. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | INTS10 |
Name | integrator complex subunit 10 |
Aliases | FLJ10569; INT10; C8orf35; chromosome 8 open reading frame 35 |
Chromosomal Location | 8p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of INTS10. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by INTS10. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | INTS10 |
Name | integrator complex subunit 10 |
Aliases | FLJ10569; INT10; C8orf35; chromosome 8 open reading frame 35 |
Chromosomal Location | 8p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of INTS10. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | INTS10 |
Name | integrator complex subunit 10 |
Aliases | FLJ10569; INT10; C8orf35; chromosome 8 open reading frame 35 |
Chromosomal Location | 8p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of INTS10 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | INTS10 |
Name | integrator complex subunit 10 |
Aliases | FLJ10569; INT10; C8orf35; chromosome 8 open reading frame 35 |
Chromosomal Location | 8p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between INTS10 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |