Summary | |
---|---|
Symbol | IPMK |
Name | inositol polyphosphate multikinase |
Aliases | inositol 1,3,4,6-tetrakisphosphate 5-kinase |
Chromosomal Location | 10q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF03770 Inositol polyphosphate kinase |
Function |
Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4). |
Biological Process |
GO:0001838 embryonic epithelial tube formation GO:0001841 neural tube formation GO:0006066 alcohol metabolic process GO:0016331 morphogenesis of embryonic epithelium GO:0019751 polyol metabolic process GO:0021915 neural tube development GO:0032958 inositol phosphate biosynthetic process GO:0035148 tube formation GO:0035239 tube morphogenesis GO:0043647 inositol phosphate metabolic process GO:0044283 small molecule biosynthetic process GO:0046165 alcohol biosynthetic process GO:0046173 polyol biosynthetic process GO:0060562 epithelial tube morphogenesis GO:0072175 epithelial tube formation GO:1901615 organic hydroxy compound metabolic process GO:1901617 organic hydroxy compound biosynthetic process |
Molecular Function |
GO:0000823 inositol-1,4,5-trisphosphate 6-kinase activity GO:0000824 inositol tetrakisphosphate 3-kinase activity GO:0000825 inositol tetrakisphosphate 6-kinase activity GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity GO:0047326 inositol tetrakisphosphate 5-kinase activity GO:0051765 inositol tetrakisphosphate kinase activity GO:0051766 inositol trisphosphate kinase activity |
Cellular Component | - |
KEGG |
hsa04070 Phosphatidylinositol signaling system hsa00562 Inositol phosphate metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-1483249: Inositol phosphate metabolism R-HSA-1430728: Metabolism R-HSA-1855191: Synthesis of IPs in the nucleus |
Summary | |
---|---|
Symbol | IPMK |
Name | inositol polyphosphate multikinase |
Aliases | inositol 1,3,4,6-tetrakisphosphate 5-kinase |
Chromosomal Location | 10q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IPMK and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | IPMK |
Name | inositol polyphosphate multikinase |
Aliases | inositol 1,3,4,6-tetrakisphosphate 5-kinase |
Chromosomal Location | 10q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IPMK in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IPMK |
Name | inositol polyphosphate multikinase |
Aliases | inositol 1,3,4,6-tetrakisphosphate 5-kinase |
Chromosomal Location | 10q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IPMK in various data sets.
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Points in the above scatter plot represent the mutation difference of IPMK in various data sets.
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Summary | |
---|---|
Symbol | IPMK |
Name | inositol polyphosphate multikinase |
Aliases | inositol 1,3,4,6-tetrakisphosphate 5-kinase |
Chromosomal Location | 10q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IPMK. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | IPMK |
Name | inositol polyphosphate multikinase |
Aliases | inositol 1,3,4,6-tetrakisphosphate 5-kinase |
Chromosomal Location | 10q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IPMK. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IPMK. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | IPMK |
Name | inositol polyphosphate multikinase |
Aliases | inositol 1,3,4,6-tetrakisphosphate 5-kinase |
Chromosomal Location | 10q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IPMK. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | IPMK |
Name | inositol polyphosphate multikinase |
Aliases | inositol 1,3,4,6-tetrakisphosphate 5-kinase |
Chromosomal Location | 10q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IPMK expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | IPMK |
Name | inositol polyphosphate multikinase |
Aliases | inositol 1,3,4,6-tetrakisphosphate 5-kinase |
Chromosomal Location | 10q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IPMK and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |