Summary | |
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Symbol | IQSEC1 |
Name | IQ motif and Sec7 domain 1 |
Aliases | KIAA0763; GEP100; BRAG2; ARF-GEP100; brefeldin A-resistant ARF-GEF2; ARFGEP100; ADP-ribosylation factors gua ...... |
Chromosomal Location | 3p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus Note=At steady state, may be preferentially cytosolic. |
Domain |
PF16453 PH domain PF01369 Sec7 domain |
Function |
Guanine nucleotide exchange factor for ARF1 and ARF6 (PubMed:24058294). Guanine nucleotide exchange factor activity is enhanced by lipid binding (PubMed:24058294). Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin. |
Biological Process |
GO:0007265 Ras protein signal transduction GO:0032011 ARF protein signal transduction GO:0032012 regulation of ARF protein signal transduction GO:0046578 regulation of Ras protein signal transduction GO:0051056 regulation of small GTPase mediated signal transduction |
Molecular Function |
GO:0005085 guanyl-nucleotide exchange factor activity GO:0005086 ARF guanyl-nucleotide exchange factor activity |
Cellular Component | - |
KEGG |
hsa04144 Endocytosis |
Reactome | - |
Summary | |
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Symbol | IQSEC1 |
Name | IQ motif and Sec7 domain 1 |
Aliases | KIAA0763; GEP100; BRAG2; ARF-GEP100; brefeldin A-resistant ARF-GEF2; ARFGEP100; ADP-ribosylation factors gua ...... |
Chromosomal Location | 3p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IQSEC1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | IQSEC1 |
Name | IQ motif and Sec7 domain 1 |
Aliases | KIAA0763; GEP100; BRAG2; ARF-GEP100; brefeldin A-resistant ARF-GEF2; ARFGEP100; ADP-ribosylation factors gua ...... |
Chromosomal Location | 3p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IQSEC1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IQSEC1 |
Name | IQ motif and Sec7 domain 1 |
Aliases | KIAA0763; GEP100; BRAG2; ARF-GEP100; brefeldin A-resistant ARF-GEF2; ARFGEP100; ADP-ribosylation factors gua ...... |
Chromosomal Location | 3p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IQSEC1 in various data sets.
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Points in the above scatter plot represent the mutation difference of IQSEC1 in various data sets.
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Summary | |
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Symbol | IQSEC1 |
Name | IQ motif and Sec7 domain 1 |
Aliases | KIAA0763; GEP100; BRAG2; ARF-GEP100; brefeldin A-resistant ARF-GEF2; ARFGEP100; ADP-ribosylation factors gua ...... |
Chromosomal Location | 3p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IQSEC1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | IQSEC1 |
Name | IQ motif and Sec7 domain 1 |
Aliases | KIAA0763; GEP100; BRAG2; ARF-GEP100; brefeldin A-resistant ARF-GEF2; ARFGEP100; ADP-ribosylation factors gua ...... |
Chromosomal Location | 3p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IQSEC1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IQSEC1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IQSEC1 |
Name | IQ motif and Sec7 domain 1 |
Aliases | KIAA0763; GEP100; BRAG2; ARF-GEP100; brefeldin A-resistant ARF-GEF2; ARFGEP100; ADP-ribosylation factors gua ...... |
Chromosomal Location | 3p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IQSEC1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | IQSEC1 |
Name | IQ motif and Sec7 domain 1 |
Aliases | KIAA0763; GEP100; BRAG2; ARF-GEP100; brefeldin A-resistant ARF-GEF2; ARFGEP100; ADP-ribosylation factors gua ...... |
Chromosomal Location | 3p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IQSEC1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | IQSEC1 |
Name | IQ motif and Sec7 domain 1 |
Aliases | KIAA0763; GEP100; BRAG2; ARF-GEP100; brefeldin A-resistant ARF-GEF2; ARFGEP100; ADP-ribosylation factors gua ...... |
Chromosomal Location | 3p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IQSEC1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | IQSEC1 |
Name | IQ motif and Sec7 domain 1 |
Aliases | KIAA0763; GEP100; BRAG2; ARF-GEP100; brefeldin A-resistant ARF-GEF2; ARFGEP100; ADP-ribosylation factors gua ...... |
Chromosomal Location | 3p25.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IQSEC1 collected from DrugBank database. |
There is no record. |