Summary | |
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Symbol | IRAK3 |
Name | interleukin-1 receptor-associated kinase 3 |
Aliases | IRAK-M; ASRT5; IRAKM; IL-1 receptor-associated kinase M; IRAK-3 |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF00531 Death domain PF00069 Protein kinase domain |
Function |
Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. |
Biological Process |
GO:0001818 negative regulation of cytokine production GO:0001933 negative regulation of protein phosphorylation GO:0001959 regulation of cytokine-mediated signaling pathway GO:0001960 negative regulation of cytokine-mediated signaling pathway GO:0002218 activation of innate immune response GO:0002221 pattern recognition receptor signaling pathway GO:0002224 toll-like receptor signaling pathway GO:0002237 response to molecule of bacterial origin GO:0002367 cytokine production involved in immune response GO:0002440 production of molecular mediator of immune response GO:0002507 tolerance induction GO:0002643 regulation of tolerance induction GO:0002645 positive regulation of tolerance induction GO:0002683 negative regulation of immune system process GO:0002697 regulation of immune effector process GO:0002698 negative regulation of immune effector process GO:0002700 regulation of production of molecular mediator of immune response GO:0002701 negative regulation of production of molecular mediator of immune response GO:0002718 regulation of cytokine production involved in immune response GO:0002719 negative regulation of cytokine production involved in immune response GO:0002755 MyD88-dependent toll-like receptor signaling pathway GO:0002757 immune response-activating signal transduction GO:0002758 innate immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0006469 negative regulation of protein kinase activity GO:0009615 response to virus GO:0009894 regulation of catabolic process GO:0009895 negative regulation of catabolic process GO:0010931 macrophage tolerance induction GO:0010932 regulation of macrophage tolerance induction GO:0010933 positive regulation of macrophage tolerance induction GO:0010934 macrophage cytokine production GO:0010935 regulation of macrophage cytokine production GO:0010936 negative regulation of macrophage cytokine production GO:0031348 negative regulation of defense response GO:0031349 positive regulation of defense response GO:0032088 negative regulation of NF-kappaB transcription factor activity GO:0032494 response to peptidoglycan GO:0032496 response to lipopolysaccharide GO:0032615 interleukin-12 production GO:0032635 interleukin-6 production GO:0032640 tumor necrosis factor production GO:0032655 regulation of interleukin-12 production GO:0032675 regulation of interleukin-6 production GO:0032680 regulation of tumor necrosis factor production GO:0032695 negative regulation of interleukin-12 production GO:0032715 negative regulation of interleukin-6 production GO:0032720 negative regulation of tumor necrosis factor production GO:0032984 macromolecular complex disassembly GO:0033673 negative regulation of kinase activity GO:0034121 regulation of toll-like receptor signaling pathway GO:0034122 negative regulation of toll-like receptor signaling pathway GO:0042176 regulation of protein catabolic process GO:0042177 negative regulation of protein catabolic process GO:0042326 negative regulation of phosphorylation GO:0043241 protein complex disassembly GO:0043242 negative regulation of protein complex disassembly GO:0043244 regulation of protein complex disassembly GO:0043330 response to exogenous dsRNA GO:0043331 response to dsRNA GO:0043405 regulation of MAP kinase activity GO:0043407 negative regulation of MAP kinase activity GO:0043409 negative regulation of MAPK cascade GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045824 negative regulation of innate immune response GO:0046777 protein autophosphorylation GO:0050777 negative regulation of immune response GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0051348 negative regulation of transferase activity GO:0060759 regulation of response to cytokine stimulus GO:0060761 negative regulation of response to cytokine stimulus GO:0061082 myeloid leukocyte cytokine production GO:0070498 interleukin-1-mediated signaling pathway GO:0070555 response to interleukin-1 GO:0071347 cellular response to interleukin-1 GO:0071706 tumor necrosis factor superfamily cytokine production GO:0071900 regulation of protein serine/threonine kinase activity GO:0071901 negative regulation of protein serine/threonine kinase activity GO:1902532 negative regulation of intracellular signal transduction GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production |
Molecular Function |
GO:0000287 magnesium ion binding GO:0004674 protein serine/threonine kinase activity GO:0046982 protein heterodimerization activity |
Cellular Component | - |
KEGG |
hsa04722 Neurotrophin signaling pathway |
Reactome |
R-HSA-166054: Activated TLR4 signalling R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-446652: Interleukin-1 signaling R-HSA-166058: MyD88 R-HSA-449147: Signaling by Interleukins R-HSA-181438: Toll Like Receptor 2 (TLR2) Cascade R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade R-HSA-168179: Toll Like Receptor TLR1 R-HSA-168188: Toll Like Receptor TLR6 R-HSA-168898: Toll-Like Receptors Cascades |
Summary | |
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Symbol | IRAK3 |
Name | interleukin-1 receptor-associated kinase 3 |
Aliases | IRAK-M; ASRT5; IRAKM; IL-1 receptor-associated kinase M; IRAK-3 |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IRAK3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | IRAK3 |
Name | interleukin-1 receptor-associated kinase 3 |
Aliases | IRAK-M; ASRT5; IRAKM; IL-1 receptor-associated kinase M; IRAK-3 |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IRAK3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IRAK3 |
Name | interleukin-1 receptor-associated kinase 3 |
Aliases | IRAK-M; ASRT5; IRAKM; IL-1 receptor-associated kinase M; IRAK-3 |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IRAK3 in various data sets.
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Points in the above scatter plot represent the mutation difference of IRAK3 in various data sets.
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Summary | |
---|---|
Symbol | IRAK3 |
Name | interleukin-1 receptor-associated kinase 3 |
Aliases | IRAK-M; ASRT5; IRAKM; IL-1 receptor-associated kinase M; IRAK-3 |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IRAK3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | IRAK3 |
Name | interleukin-1 receptor-associated kinase 3 |
Aliases | IRAK-M; ASRT5; IRAKM; IL-1 receptor-associated kinase M; IRAK-3 |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IRAK3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IRAK3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IRAK3 |
Name | interleukin-1 receptor-associated kinase 3 |
Aliases | IRAK-M; ASRT5; IRAKM; IL-1 receptor-associated kinase M; IRAK-3 |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IRAK3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | IRAK3 |
Name | interleukin-1 receptor-associated kinase 3 |
Aliases | IRAK-M; ASRT5; IRAKM; IL-1 receptor-associated kinase M; IRAK-3 |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IRAK3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | IRAK3 |
Name | interleukin-1 receptor-associated kinase 3 |
Aliases | IRAK-M; ASRT5; IRAKM; IL-1 receptor-associated kinase M; IRAK-3 |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IRAK3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | IRAK3 |
Name | interleukin-1 receptor-associated kinase 3 |
Aliases | IRAK-M; ASRT5; IRAKM; IL-1 receptor-associated kinase M; IRAK-3 |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IRAK3 collected from DrugBank database. |
There is no record. |