Summary | |
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Symbol | IRF1 |
Name | interferon regulatory factor 1 |
Aliases | MAR; interferon regulatory factor-1; IRF-1; interferon regulatory factor 1 isoform +I9; interferon regulator ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. Cytoplasm. Note=MYD88-associated IRF1 migrates into the nucleus more efficiently than non-MYD88-associated IRF1. |
Domain |
PF00605 Interferon regulatory factor transcription factor |
Function |
Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters. Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA. Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4. Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53. Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells. Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development. Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells. |
Biological Process |
GO:0001819 positive regulation of cytokine production GO:0002218 activation of innate immune response GO:0002221 pattern recognition receptor signaling pathway GO:0002224 toll-like receptor signaling pathway GO:0002250 adaptive immune response GO:0002521 leukocyte differentiation GO:0002683 negative regulation of immune system process GO:0002694 regulation of leukocyte activation GO:0002695 negative regulation of leukocyte activation GO:0002755 MyD88-dependent toll-like receptor signaling pathway GO:0002757 immune response-activating signal transduction GO:0002758 innate immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002819 regulation of adaptive immune response GO:0007050 cell cycle arrest GO:0007159 leukocyte cell-cell adhesion GO:0007162 negative regulation of cell adhesion GO:0007596 blood coagulation GO:0007599 hemostasis GO:0009612 response to mechanical stimulus GO:0009615 response to virus GO:0022407 regulation of cell-cell adhesion GO:0022408 negative regulation of cell-cell adhesion GO:0030098 lymphocyte differentiation GO:0030217 T cell differentiation GO:0031349 positive regulation of defense response GO:0032479 regulation of type I interferon production GO:0032481 positive regulation of type I interferon production GO:0032606 type I interferon production GO:0032608 interferon-beta production GO:0032615 interleukin-12 production GO:0032648 regulation of interferon-beta production GO:0032655 regulation of interleukin-12 production GO:0032728 positive regulation of interferon-beta production GO:0032735 positive regulation of interleukin-12 production GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0034121 regulation of toll-like receptor signaling pathway GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway GO:0034340 response to type I interferon GO:0034341 response to interferon-gamma GO:0035456 response to interferon-beta GO:0035458 cellular response to interferon-beta GO:0035740 CD8-positive, alpha-beta T cell proliferation GO:0036037 CD8-positive, alpha-beta T cell activation GO:0042035 regulation of cytokine biosynthetic process GO:0042089 cytokine biosynthetic process GO:0042090 interleukin-12 biosynthetic process GO:0042098 T cell proliferation GO:0042107 cytokine metabolic process GO:0042108 positive regulation of cytokine biosynthetic process GO:0042110 T cell activation GO:0042129 regulation of T cell proliferation GO:0043374 CD8-positive, alpha-beta T cell differentiation GO:0045066 regulatory T cell differentiation GO:0045075 regulation of interleukin-12 biosynthetic process GO:0045084 positive regulation of interleukin-12 biosynthetic process GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045580 regulation of T cell differentiation GO:0045581 negative regulation of T cell differentiation GO:0045589 regulation of regulatory T cell differentiation GO:0045590 negative regulation of regulatory T cell differentiation GO:0045619 regulation of lymphocyte differentiation GO:0045620 negative regulation of lymphocyte differentiation GO:0045786 negative regulation of cell cycle GO:0046631 alpha-beta T cell activation GO:0046632 alpha-beta T cell differentiation GO:0046633 alpha-beta T cell proliferation GO:0046634 regulation of alpha-beta T cell activation GO:0046640 regulation of alpha-beta T cell proliferation GO:0046651 lymphocyte proliferation GO:0050670 regulation of lymphocyte proliferation GO:0050817 coagulation GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050866 negative regulation of cell activation GO:0050868 negative regulation of T cell activation GO:0050878 regulation of body fluid levels GO:0051249 regulation of lymphocyte activation GO:0051250 negative regulation of lymphocyte activation GO:0051607 defense response to virus GO:0060333 interferon-gamma-mediated signaling pathway GO:0060337 type I interferon signaling pathway GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0071214 cellular response to abiotic stimulus GO:0071260 cellular response to mechanical stimulus GO:0071346 cellular response to interferon-gamma GO:0071357 cellular response to type I interferon GO:0071496 cellular response to external stimulus GO:0071593 lymphocyte aggregation GO:0098542 defense response to other organism GO:1902105 regulation of leukocyte differentiation GO:1902106 negative regulation of leukocyte differentiation GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903038 negative regulation of leukocyte cell-cell adhesion GO:1903706 regulation of hemopoiesis GO:1903707 negative regulation of hemopoiesis GO:2000564 regulation of CD8-positive, alpha-beta T cell proliferation GO:2001185 regulation of CD8-positive, alpha-beta T cell activation |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001159 core promoter proximal region DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding |
Cellular Component |
GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0044454 nuclear chromosome part |
KEGG |
hsa04917 Prolactin signaling pathway |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-983231: Factors involved in megakaryocyte development and platelet production R-HSA-109582: Hemostasis R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-913531: Interferon Signaling R-HSA-909733: Interferon alpha/beta signaling R-HSA-877300: Interferon gamma signaling R-HSA-168928: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways R-HSA-933541: TRAF6 mediated IRF7 activation |
Summary | |
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Symbol | IRF1 |
Name | interferon regulatory factor 1 |
Aliases | MAR; interferon regulatory factor-1; IRF-1; interferon regulatory factor 1 isoform +I9; interferon regulator ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IRF1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between IRF1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | IRF1 |
Name | interferon regulatory factor 1 |
Aliases | MAR; interferon regulatory factor-1; IRF-1; interferon regulatory factor 1 isoform +I9; interferon regulator ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IRF1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IRF1 |
Name | interferon regulatory factor 1 |
Aliases | MAR; interferon regulatory factor-1; IRF-1; interferon regulatory factor 1 isoform +I9; interferon regulator ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IRF1 in various data sets.
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Points in the above scatter plot represent the mutation difference of IRF1 in various data sets.
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Summary | |
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Symbol | IRF1 |
Name | interferon regulatory factor 1 |
Aliases | MAR; interferon regulatory factor-1; IRF-1; interferon regulatory factor 1 isoform +I9; interferon regulator ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IRF1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | IRF1 |
Name | interferon regulatory factor 1 |
Aliases | MAR; interferon regulatory factor-1; IRF-1; interferon regulatory factor 1 isoform +I9; interferon regulator ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IRF1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IRF1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IRF1 |
Name | interferon regulatory factor 1 |
Aliases | MAR; interferon regulatory factor-1; IRF-1; interferon regulatory factor 1 isoform +I9; interferon regulator ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IRF1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | IRF1 |
Name | interferon regulatory factor 1 |
Aliases | MAR; interferon regulatory factor-1; IRF-1; interferon regulatory factor 1 isoform +I9; interferon regulator ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IRF1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | IRF1 |
Name | interferon regulatory factor 1 |
Aliases | MAR; interferon regulatory factor-1; IRF-1; interferon regulatory factor 1 isoform +I9; interferon regulator ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IRF1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | IRF1 |
Name | interferon regulatory factor 1 |
Aliases | MAR; interferon regulatory factor-1; IRF-1; interferon regulatory factor 1 isoform +I9; interferon regulator ...... |
Chromosomal Location | 5q23-q31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IRF1 collected from DrugBank database. |
There is no record. |