Summary | |
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Symbol | IRF5 |
Name | interferon regulatory factor 5 |
Aliases | SLEB10; IRF-5 |
Chromosomal Location | 7q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. |
Domain |
PF00605 Interferon regulatory factor transcription factor PF10401 Interferon-regulatory factor 3 |
Function |
Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling. |
Biological Process |
GO:0001819 positive regulation of cytokine production GO:0002237 response to molecule of bacterial origin GO:0009615 response to virus GO:0032479 regulation of type I interferon production GO:0032481 positive regulation of type I interferon production GO:0032494 response to peptidoglycan GO:0032495 response to muramyl dipeptide GO:0032606 type I interferon production GO:0032607 interferon-alpha production GO:0032608 interferon-beta production GO:0032615 interleukin-12 production GO:0032647 regulation of interferon-alpha production GO:0032648 regulation of interferon-beta production GO:0032655 regulation of interleukin-12 production GO:0032727 positive regulation of interferon-alpha production GO:0032728 positive regulation of interferon-beta production GO:0032735 positive regulation of interleukin-12 production GO:0034340 response to type I interferon GO:0034341 response to interferon-gamma GO:0051607 defense response to virus GO:0060333 interferon-gamma-mediated signaling pathway GO:0060337 type I interferon signaling pathway GO:0071346 cellular response to interferon-gamma GO:0071357 cellular response to type I interferon GO:0098542 defense response to other organism GO:1901652 response to peptide |
Molecular Function | - |
Cellular Component | - |
KEGG |
hsa04620 Toll-like receptor signaling pathway |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-913531: Interferon Signaling R-HSA-909733: Interferon alpha/beta signaling R-HSA-877300: Interferon gamma signaling |
Summary | |
---|---|
Symbol | IRF5 |
Name | interferon regulatory factor 5 |
Aliases | SLEB10; IRF-5 |
Chromosomal Location | 7q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IRF5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between IRF5 and anti-tumor immunity in human cancer.
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Summary | |
---|---|
Symbol | IRF5 |
Name | interferon regulatory factor 5 |
Aliases | SLEB10; IRF-5 |
Chromosomal Location | 7q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IRF5 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | IRF5 |
Name | interferon regulatory factor 5 |
Aliases | SLEB10; IRF-5 |
Chromosomal Location | 7q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IRF5 in various data sets.
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Points in the above scatter plot represent the mutation difference of IRF5 in various data sets.
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Summary | |
---|---|
Symbol | IRF5 |
Name | interferon regulatory factor 5 |
Aliases | SLEB10; IRF-5 |
Chromosomal Location | 7q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IRF5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | IRF5 |
Name | interferon regulatory factor 5 |
Aliases | SLEB10; IRF-5 |
Chromosomal Location | 7q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IRF5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IRF5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | IRF5 |
Name | interferon regulatory factor 5 |
Aliases | SLEB10; IRF-5 |
Chromosomal Location | 7q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IRF5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | IRF5 |
Name | interferon regulatory factor 5 |
Aliases | SLEB10; IRF-5 |
Chromosomal Location | 7q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IRF5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | IRF5 |
Name | interferon regulatory factor 5 |
Aliases | SLEB10; IRF-5 |
Chromosomal Location | 7q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IRF5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |