Summary | |
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Symbol | IRF7 |
Name | interferon regulatory factor 7 |
Aliases | IMD39; IRF-7HA; IRF7B; IRF7C; IRF7H; IRF-7; interferon regulatory factor-7H |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. Cytoplasm. Note=The phosphorylated and active form accumulates selectively in the nucleus. |
Domain |
PF00605 Interferon regulatory factor transcription factor PF10401 Interferon-regulatory factor 3 |
Function |
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages. |
Biological Process |
GO:0001819 positive regulation of cytokine production GO:0001959 regulation of cytokine-mediated signaling pathway GO:0001961 positive regulation of cytokine-mediated signaling pathway GO:0002218 activation of innate immune response GO:0002221 pattern recognition receptor signaling pathway GO:0002224 toll-like receptor signaling pathway GO:0002250 adaptive immune response GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0002755 MyD88-dependent toll-like receptor signaling pathway GO:0002756 MyD88-independent toll-like receptor signaling pathway GO:0002757 immune response-activating signal transduction GO:0002758 innate immune response-activating signal transduction GO:0002761 regulation of myeloid leukocyte differentiation GO:0002764 immune response-regulating signaling pathway GO:0002819 regulation of adaptive immune response GO:0006925 inflammatory cell apoptotic process GO:0009615 response to virus GO:0016064 immunoglobulin mediated immune response GO:0019042 viral latency GO:0019043 establishment of viral latency GO:0019724 B cell mediated immunity GO:0030099 myeloid cell differentiation GO:0030224 monocyte differentiation GO:0030522 intracellular receptor signaling pathway GO:0031349 positive regulation of defense response GO:0032479 regulation of type I interferon production GO:0032481 positive regulation of type I interferon production GO:0032606 type I interferon production GO:0032607 interferon-alpha production GO:0032608 interferon-beta production GO:0032647 regulation of interferon-alpha production GO:0032648 regulation of interferon-beta production GO:0032727 positive regulation of interferon-alpha production GO:0032728 positive regulation of interferon-beta production GO:0033028 myeloid cell apoptotic process GO:0033032 regulation of myeloid cell apoptotic process GO:0033033 negative regulation of myeloid cell apoptotic process GO:0034121 regulation of toll-like receptor signaling pathway GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway GO:0034127 regulation of MyD88-independent toll-like receptor signaling pathway GO:0034340 response to type I interferon GO:0034341 response to interferon-gamma GO:0035666 TRIF-dependent toll-like receptor signaling pathway GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus GO:0039530 MDA-5 signaling pathway GO:0042089 cytokine biosynthetic process GO:0042107 cytokine metabolic process GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045351 type I interferon biosynthetic process GO:0045637 regulation of myeloid cell differentiation GO:0045655 regulation of monocyte differentiation GO:0051607 defense response to virus GO:0060333 interferon-gamma-mediated signaling pathway GO:0060337 type I interferon signaling pathway GO:0060338 regulation of type I interferon-mediated signaling pathway GO:0060340 positive regulation of type I interferon-mediated signaling pathway GO:0060759 regulation of response to cytokine stimulus GO:0060760 positive regulation of response to cytokine stimulus GO:0071346 cellular response to interferon-gamma GO:0071357 cellular response to type I interferon GO:0071887 leukocyte apoptotic process GO:0071888 macrophage apoptotic process GO:0098542 defense response to other organism GO:0098586 cellular response to virus GO:1902105 regulation of leukocyte differentiation GO:1903131 mononuclear cell differentiation GO:1903706 regulation of hemopoiesis GO:2000106 regulation of leukocyte apoptotic process GO:2000107 negative regulation of leukocyte apoptotic process GO:2000109 regulation of macrophage apoptotic process GO:2000110 negative regulation of macrophage apoptotic process |
Molecular Function |
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001046 core promoter sequence-specific DNA binding GO:0001047 core promoter binding |
Cellular Component |
GO:0010008 endosome membrane GO:0044440 endosomal part |
KEGG |
hsa04620 Toll-like receptor signaling pathway hsa04621 NOD-like receptor signaling pathway hsa04622 RIG-I-like receptor signaling pathway hsa04623 Cytosolic DNA-sensing pathway |
Reactome |
R-HSA-166054: Activated TLR4 signalling R-HSA-936964: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-1834949: Cytosolic sensors of pathogen-associated DNA R-HSA-3134963: DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-983231: Factors involved in megakaryocyte development and platelet production R-HSA-109582: Hemostasis R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-913531: Interferon Signaling R-HSA-909733: Interferon alpha/beta signaling R-HSA-877300: Interferon gamma signaling R-HSA-975155: MyD88 dependent cascade initiated on endosome R-HSA-166166: MyD88-independent TLR3/TLR4 cascade R-HSA-168928: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways R-HSA-918233: TRAF3-dependent IRF activation pathway R-HSA-933541: TRAF6 mediated IRF7 activation R-HSA-975110: TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-937061: TRIF-mediated TLR3/TLR4 signaling R-HSA-168164: Toll Like Receptor 3 (TLR3) Cascade R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade R-HSA-168181: Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168138: Toll Like Receptor 9 (TLR9) Cascade R-HSA-168898: Toll-Like Receptors Cascades |
Summary | |
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Symbol | IRF7 |
Name | interferon regulatory factor 7 |
Aliases | IMD39; IRF-7HA; IRF7B; IRF7C; IRF7H; IRF-7; interferon regulatory factor-7H |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IRF7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between IRF7 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | IRF7 |
Name | interferon regulatory factor 7 |
Aliases | IMD39; IRF-7HA; IRF7B; IRF7C; IRF7H; IRF-7; interferon regulatory factor-7H |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IRF7 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IRF7 |
Name | interferon regulatory factor 7 |
Aliases | IMD39; IRF-7HA; IRF7B; IRF7C; IRF7H; IRF-7; interferon regulatory factor-7H |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IRF7 in various data sets.
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Points in the above scatter plot represent the mutation difference of IRF7 in various data sets.
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Summary | |
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Symbol | IRF7 |
Name | interferon regulatory factor 7 |
Aliases | IMD39; IRF-7HA; IRF7B; IRF7C; IRF7H; IRF-7; interferon regulatory factor-7H |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IRF7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | IRF7 |
Name | interferon regulatory factor 7 |
Aliases | IMD39; IRF-7HA; IRF7B; IRF7C; IRF7H; IRF-7; interferon regulatory factor-7H |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IRF7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IRF7. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IRF7 |
Name | interferon regulatory factor 7 |
Aliases | IMD39; IRF-7HA; IRF7B; IRF7C; IRF7H; IRF-7; interferon regulatory factor-7H |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IRF7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | IRF7 |
Name | interferon regulatory factor 7 |
Aliases | IMD39; IRF-7HA; IRF7B; IRF7C; IRF7H; IRF-7; interferon regulatory factor-7H |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IRF7 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | IRF7 |
Name | interferon regulatory factor 7 |
Aliases | IMD39; IRF-7HA; IRF7B; IRF7C; IRF7H; IRF-7; interferon regulatory factor-7H |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IRF7 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | IRF7 |
Name | interferon regulatory factor 7 |
Aliases | IMD39; IRF-7HA; IRF7B; IRF7C; IRF7H; IRF-7; interferon regulatory factor-7H |
Chromosomal Location | 11p15.5 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IRF7 collected from DrugBank database. |
There is no record. |