Summary | |
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Symbol | IRGM |
Name | immunity-related GTPase family, M |
Aliases | LRG47; LRG-47; IFI1; IRGM1; immunity-related GTPase family, M1; IFI11; LPS-stimulated RAW 264.7 macrophage p ...... |
Chromosomal Location | 5q33.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Golgi apparatus membrane Cell membrane Cytoplasmic vesicle, phagosome membrane Cytoplasmic vesicle, autophagosome membrane Cell projection, phagocytic cup Note=Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes. Preferentially associated with cis- and medial-Golgi. |
Domain |
PF05049 Interferon-inducible GTPase (IIGP) |
Function |
Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity). |
Biological Process |
GO:0006914 autophagy GO:0035456 response to interferon-beta GO:0035458 cellular response to interferon-beta |
Molecular Function |
GO:0003924 GTPase activity GO:0005525 GTP binding GO:0019001 guanyl nucleotide binding GO:0032561 guanyl ribonucleotide binding |
Cellular Component |
GO:0000421 autophagosome membrane GO:0001891 phagocytic cup GO:0005776 autophagosome GO:0030139 endocytic vesicle GO:0030659 cytoplasmic vesicle membrane GO:0030666 endocytic vesicle membrane GO:0030670 phagocytic vesicle membrane GO:0045335 phagocytic vesicle |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | IRGM |
Name | immunity-related GTPase family, M |
Aliases | LRG47; LRG-47; IFI1; IRGM1; immunity-related GTPase family, M1; IFI11; LPS-stimulated RAW 264.7 macrophage p ...... |
Chromosomal Location | 5q33.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IRGM and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | IRGM |
Name | immunity-related GTPase family, M |
Aliases | LRG47; LRG-47; IFI1; IRGM1; immunity-related GTPase family, M1; IFI11; LPS-stimulated RAW 264.7 macrophage p ...... |
Chromosomal Location | 5q33.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IRGM in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IRGM |
Name | immunity-related GTPase family, M |
Aliases | LRG47; LRG-47; IFI1; IRGM1; immunity-related GTPase family, M1; IFI11; LPS-stimulated RAW 264.7 macrophage p ...... |
Chromosomal Location | 5q33.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IRGM in various data sets.
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Points in the above scatter plot represent the mutation difference of IRGM in various data sets.
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Summary | |
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Symbol | IRGM |
Name | immunity-related GTPase family, M |
Aliases | LRG47; LRG-47; IFI1; IRGM1; immunity-related GTPase family, M1; IFI11; LPS-stimulated RAW 264.7 macrophage p ...... |
Chromosomal Location | 5q33.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IRGM. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | IRGM |
Name | immunity-related GTPase family, M |
Aliases | LRG47; LRG-47; IFI1; IRGM1; immunity-related GTPase family, M1; IFI11; LPS-stimulated RAW 264.7 macrophage p ...... |
Chromosomal Location | 5q33.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IRGM. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IRGM. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IRGM |
Name | immunity-related GTPase family, M |
Aliases | LRG47; LRG-47; IFI1; IRGM1; immunity-related GTPase family, M1; IFI11; LPS-stimulated RAW 264.7 macrophage p ...... |
Chromosomal Location | 5q33.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IRGM. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | IRGM |
Name | immunity-related GTPase family, M |
Aliases | LRG47; LRG-47; IFI1; IRGM1; immunity-related GTPase family, M1; IFI11; LPS-stimulated RAW 264.7 macrophage p ...... |
Chromosomal Location | 5q33.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IRGM expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | IRGM |
Name | immunity-related GTPase family, M |
Aliases | LRG47; LRG-47; IFI1; IRGM1; immunity-related GTPase family, M1; IFI11; LPS-stimulated RAW 264.7 macrophage p ...... |
Chromosomal Location | 5q33.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IRGM and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | IRGM |
Name | immunity-related GTPase family, M |
Aliases | LRG47; LRG-47; IFI1; IRGM1; immunity-related GTPase family, M1; IFI11; LPS-stimulated RAW 264.7 macrophage p ...... |
Chromosomal Location | 5q33.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IRGM collected from DrugBank database. |
There is no record. |