Browse IRX1

Summary
SymbolIRX1
Nameiroquois homeobox 1
Aliases IRX-5; IRXA1; homeodomain protein IRXA1; iroquois homeobox protein 1
Chromosomal Location5p15.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF05920 Homeobox KN domain
Function

-

> Gene Ontology
 
Biological Process GO:0001655 urogenital system development
GO:0001656 metanephros development
GO:0001822 kidney development
GO:0001838 embryonic epithelial tube formation
GO:0003002 regionalization
GO:0007379 segment specification
GO:0007389 pattern specification process
GO:0009954 proximal/distal pattern formation
GO:0016331 morphogenesis of embryonic epithelium
GO:0035148 tube formation
GO:0035239 tube morphogenesis
GO:0035282 segmentation
GO:0060562 epithelial tube morphogenesis
GO:0060993 kidney morphogenesis
GO:0061004 pattern specification involved in kidney development
GO:0061326 renal tubule development
GO:0061333 renal tubule morphogenesis
GO:0072001 renal system development
GO:0072006 nephron development
GO:0072009 nephron epithelium development
GO:0072028 nephron morphogenesis
GO:0072047 proximal/distal pattern formation involved in nephron development
GO:0072048 renal system pattern specification
GO:0072070 loop of Henle development
GO:0072073 kidney epithelium development
GO:0072078 nephron tubule morphogenesis
GO:0072079 nephron tubule formation
GO:0072080 nephron tubule development
GO:0072081 specification of nephron tubule identity
GO:0072086 specification of loop of Henle identity
GO:0072088 nephron epithelium morphogenesis
GO:0072175 epithelial tube formation
GO:0072210 metanephric nephron development
GO:0072268 pattern specification involved in metanephros development
GO:0072272 proximal/distal pattern formation involved in metanephric nephron development
Molecular Function -
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolIRX1
Nameiroquois homeobox 1
Aliases IRX-5; IRXA1; homeodomain protein IRXA1; iroquois homeobox protein 1
Chromosomal Location5p15.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between IRX1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolIRX1
Nameiroquois homeobox 1
Aliases IRX-5; IRXA1; homeodomain protein IRXA1; iroquois homeobox protein 1
Chromosomal Location5p15.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of IRX1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolIRX1
Nameiroquois homeobox 1
Aliases IRX-5; IRXA1; homeodomain protein IRXA1; iroquois homeobox protein 1
Chromosomal Location5p15.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of IRX1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.0810.0301
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.9040.279
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-1.190.074
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.3590.61
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.0360.336
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.4920.691
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-1.260.157
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-1.0930.393
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-1.1460.457
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 4801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 2801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.6820.0319
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of IRX1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.63.7-1.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.57.7-3.21
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolIRX1
Nameiroquois homeobox 1
Aliases IRX-5; IRXA1; homeodomain protein IRXA1; iroquois homeobox protein 1
Chromosomal Location5p15.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IRX1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolIRX1
Nameiroquois homeobox 1
Aliases IRX-5; IRXA1; homeodomain protein IRXA1; iroquois homeobox protein 1
Chromosomal Location5p15.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IRX1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IRX1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolIRX1
Nameiroquois homeobox 1
Aliases IRX-5; IRXA1; homeodomain protein IRXA1; iroquois homeobox protein 1
Chromosomal Location5p15.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IRX1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolIRX1
Nameiroquois homeobox 1
Aliases IRX-5; IRXA1; homeodomain protein IRXA1; iroquois homeobox protein 1
Chromosomal Location5p15.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of IRX1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolIRX1
Nameiroquois homeobox 1
Aliases IRX-5; IRXA1; homeodomain protein IRXA1; iroquois homeobox protein 1
Chromosomal Location5p15.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between IRX1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolIRX1
Nameiroquois homeobox 1
Aliases IRX-5; IRXA1; homeodomain protein IRXA1; iroquois homeobox protein 1
Chromosomal Location5p15.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting IRX1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.