Summary | |
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Symbol | IRX1 |
Name | iroquois homeobox 1 |
Aliases | IRX-5; IRXA1; homeodomain protein IRXA1; iroquois homeobox protein 1 |
Chromosomal Location | 5p15.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF05920 Homeobox KN domain |
Function |
- |
Biological Process |
GO:0001655 urogenital system development GO:0001656 metanephros development GO:0001822 kidney development GO:0001838 embryonic epithelial tube formation GO:0003002 regionalization GO:0007379 segment specification GO:0007389 pattern specification process GO:0009954 proximal/distal pattern formation GO:0016331 morphogenesis of embryonic epithelium GO:0035148 tube formation GO:0035239 tube morphogenesis GO:0035282 segmentation GO:0060562 epithelial tube morphogenesis GO:0060993 kidney morphogenesis GO:0061004 pattern specification involved in kidney development GO:0061326 renal tubule development GO:0061333 renal tubule morphogenesis GO:0072001 renal system development GO:0072006 nephron development GO:0072009 nephron epithelium development GO:0072028 nephron morphogenesis GO:0072047 proximal/distal pattern formation involved in nephron development GO:0072048 renal system pattern specification GO:0072070 loop of Henle development GO:0072073 kidney epithelium development GO:0072078 nephron tubule morphogenesis GO:0072079 nephron tubule formation GO:0072080 nephron tubule development GO:0072081 specification of nephron tubule identity GO:0072086 specification of loop of Henle identity GO:0072088 nephron epithelium morphogenesis GO:0072175 epithelial tube formation GO:0072210 metanephric nephron development GO:0072268 pattern specification involved in metanephros development GO:0072272 proximal/distal pattern formation involved in metanephric nephron development |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | IRX1 |
Name | iroquois homeobox 1 |
Aliases | IRX-5; IRXA1; homeodomain protein IRXA1; iroquois homeobox protein 1 |
Chromosomal Location | 5p15.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IRX1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | IRX1 |
Name | iroquois homeobox 1 |
Aliases | IRX-5; IRXA1; homeodomain protein IRXA1; iroquois homeobox protein 1 |
Chromosomal Location | 5p15.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IRX1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IRX1 |
Name | iroquois homeobox 1 |
Aliases | IRX-5; IRXA1; homeodomain protein IRXA1; iroquois homeobox protein 1 |
Chromosomal Location | 5p15.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IRX1 in various data sets.
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Points in the above scatter plot represent the mutation difference of IRX1 in various data sets.
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Summary | |
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Symbol | IRX1 |
Name | iroquois homeobox 1 |
Aliases | IRX-5; IRXA1; homeodomain protein IRXA1; iroquois homeobox protein 1 |
Chromosomal Location | 5p15.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IRX1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | IRX1 |
Name | iroquois homeobox 1 |
Aliases | IRX-5; IRXA1; homeodomain protein IRXA1; iroquois homeobox protein 1 |
Chromosomal Location | 5p15.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IRX1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IRX1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IRX1 |
Name | iroquois homeobox 1 |
Aliases | IRX-5; IRXA1; homeodomain protein IRXA1; iroquois homeobox protein 1 |
Chromosomal Location | 5p15.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IRX1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | IRX1 |
Name | iroquois homeobox 1 |
Aliases | IRX-5; IRXA1; homeodomain protein IRXA1; iroquois homeobox protein 1 |
Chromosomal Location | 5p15.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IRX1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | IRX1 |
Name | iroquois homeobox 1 |
Aliases | IRX-5; IRXA1; homeodomain protein IRXA1; iroquois homeobox protein 1 |
Chromosomal Location | 5p15.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IRX1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |