Summary | |
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Symbol | ISL1 |
Name | ISL LIM homeobox 1 |
Aliases | Isl-1; ISLET1; ISL1 transcription factor, LIM/homeodomain, (islet-1); ISL1 transcription factor, LIM/homeodo ...... |
Chromosomal Location | 5q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF00046 Homeobox domain PF00412 LIM domain |
Function |
DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for heart development. Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart. Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart (By similarity). |
Biological Process |
GO:0001525 angiogenesis GO:0001667 ameboidal-type cell migration GO:0001708 cell fate specification GO:0001709 cell fate determination GO:0001755 neural crest cell migration GO:0001819 positive regulation of cytokine production GO:0002790 peptide secretion GO:0002791 regulation of peptide secretion GO:0002793 positive regulation of peptide secretion GO:0003002 regionalization GO:0003007 heart morphogenesis GO:0003128 heart field specification GO:0003139 secondary heart field specification GO:0003148 outflow tract septum morphogenesis GO:0003151 outflow tract morphogenesis GO:0003156 regulation of animal organ formation GO:0003197 endocardial cushion development GO:0003203 endocardial cushion morphogenesis GO:0003205 cardiac chamber development GO:0003206 cardiac chamber morphogenesis GO:0003208 cardiac ventricle morphogenesis GO:0003209 cardiac atrium morphogenesis GO:0003215 cardiac right ventricle morphogenesis GO:0003229 ventricular cardiac muscle tissue development GO:0003230 cardiac atrium development GO:0003231 cardiac ventricle development GO:0003263 cardioblast proliferation GO:0003264 regulation of cardioblast proliferation GO:0003266 regulation of secondary heart field cardioblast proliferation GO:0003279 cardiac septum development GO:0003283 atrial septum development GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0007259 JAK-STAT cascade GO:0007260 tyrosine phosphorylation of STAT protein GO:0007389 pattern specification process GO:0007409 axonogenesis GO:0007411 axon guidance GO:0007422 peripheral nervous system development GO:0007507 heart development GO:0007517 muscle organ development GO:0009306 protein secretion GO:0009755 hormone-mediated signaling pathway GO:0009914 hormone transport GO:0010002 cardioblast differentiation GO:0010092 specification of animal organ identity GO:0010573 vascular endothelial growth factor production GO:0010574 regulation of vascular endothelial growth factor production GO:0010575 positive regulation of vascular endothelial growth factor production GO:0010721 negative regulation of cell development GO:0010817 regulation of hormone levels GO:0014031 mesenchymal cell development GO:0014032 neural crest cell development GO:0014033 neural crest cell differentiation GO:0014706 striated muscle tissue development GO:0015833 peptide transport GO:0016055 Wnt signaling pathway GO:0016570 histone modification GO:0016573 histone acetylation GO:0018108 peptidyl-tyrosine phosphorylation GO:0018205 peptidyl-lysine modification GO:0018212 peptidyl-tyrosine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0021510 spinal cord development GO:0021515 cell differentiation in spinal cord GO:0021517 ventral spinal cord development GO:0021520 spinal cord motor neuron cell fate specification GO:0021522 spinal cord motor neuron differentiation GO:0021524 visceral motor neuron differentiation GO:0021536 diencephalon development GO:0021545 cranial nerve development GO:0021559 trigeminal nerve development GO:0021675 nerve development GO:0021953 central nervous system neuron differentiation GO:0021983 pituitary gland development GO:0023061 signal release GO:0030072 peptide hormone secretion GO:0030073 insulin secretion GO:0030111 regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0030518 intracellular steroid hormone receptor signaling pathway GO:0030520 intracellular estrogen receptor signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0030900 forebrain development GO:0031016 pancreas development GO:0031056 regulation of histone modification GO:0031058 positive regulation of histone modification GO:0031099 regeneration GO:0031102 neuron projection regeneration GO:0031103 axon regeneration GO:0031290 retinal ganglion cell axon guidance GO:0031348 negative regulation of defense response GO:0031960 response to corticosteroid GO:0032024 positive regulation of insulin secretion GO:0032091 negative regulation of protein binding GO:0032102 negative regulation of response to external stimulus GO:0032604 granulocyte macrophage colony-stimulating factor production GO:0032609 interferon-gamma production GO:0032610 interleukin-1 alpha production GO:0032611 interleukin-1 beta production GO:0032612 interleukin-1 production GO:0032615 interleukin-12 production GO:0032635 interleukin-6 production GO:0032640 tumor necrosis factor production GO:0032645 regulation of granulocyte macrophage colony-stimulating factor production GO:0032649 regulation of interferon-gamma production GO:0032650 regulation of interleukin-1 alpha production GO:0032651 regulation of interleukin-1 beta production GO:0032652 regulation of interleukin-1 production GO:0032655 regulation of interleukin-12 production GO:0032675 regulation of interleukin-6 production GO:0032680 regulation of tumor necrosis factor production GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032729 positive regulation of interferon-gamma production GO:0032730 positive regulation of interleukin-1 alpha production GO:0032731 positive regulation of interleukin-1 beta production GO:0032732 positive regulation of interleukin-1 production GO:0032735 positive regulation of interleukin-12 production GO:0032755 positive regulation of interleukin-6 production GO:0032760 positive regulation of tumor necrosis factor production GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway GO:0033146 regulation of intracellular estrogen receptor signaling pathway GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway GO:0035051 cardiocyte differentiation GO:0035065 regulation of histone acetylation GO:0035066 positive regulation of histone acetylation GO:0035270 endocrine system development GO:0036301 macrophage colony-stimulating factor production GO:0042503 tyrosine phosphorylation of Stat3 protein GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO:0042516 regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0042692 muscle cell differentiation GO:0042886 amide transport GO:0043388 positive regulation of DNA binding GO:0043393 regulation of protein binding GO:0043401 steroid hormone mediated signaling pathway GO:0043496 regulation of protein homodimerization activity GO:0043523 regulation of neuron apoptotic process GO:0043524 negative regulation of neuron apoptotic process GO:0043543 protein acylation GO:0045165 cell fate commitment GO:0045445 myoblast differentiation GO:0045665 negative regulation of neuron differentiation GO:0045765 regulation of angiogenesis GO:0045766 positive regulation of angiogenesis GO:0046425 regulation of JAK-STAT cascade GO:0046427 positive regulation of JAK-STAT cascade GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0046887 positive regulation of hormone secretion GO:0048514 blood vessel morphogenesis GO:0048545 response to steroid hormone GO:0048644 muscle organ morphogenesis GO:0048645 animal organ formation GO:0048663 neuron fate commitment GO:0048665 neuron fate specification GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048678 response to axon injury GO:0048732 gland development GO:0048738 cardiac muscle tissue development GO:0048762 mesenchymal cell differentiation GO:0048863 stem cell differentiation GO:0048864 stem cell development GO:0048880 sensory system development GO:0048934 peripheral nervous system neuron differentiation GO:0048935 peripheral nervous system neuron development GO:0048936 peripheral nervous system neuron axonogenesis GO:0050708 regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0050727 regulation of inflammatory response GO:0050728 negative regulation of inflammatory response GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050768 negative regulation of neurogenesis GO:0050796 regulation of insulin secretion GO:0051047 positive regulation of secretion GO:0051098 regulation of binding GO:0051099 positive regulation of binding GO:0051100 negative regulation of binding GO:0051101 regulation of DNA binding GO:0051222 positive regulation of protein transport GO:0051384 response to glucocorticoid GO:0051402 neuron apoptotic process GO:0051961 negative regulation of nervous system development GO:0055008 cardiac muscle tissue morphogenesis GO:0055010 ventricular cardiac muscle tissue morphogenesis GO:0060037 pharyngeal system development GO:0060070 canonical Wnt signaling pathway GO:0060379 cardiac muscle cell myoblast differentiation GO:0060384 innervation GO:0060411 cardiac septum morphogenesis GO:0060413 atrial septum morphogenesis GO:0060415 muscle tissue morphogenesis GO:0060485 mesenchyme development GO:0060537 muscle tissue development GO:0060828 regulation of canonical Wnt signaling pathway GO:0060911 cardiac cell fate commitment GO:0060913 cardiac cell fate determination GO:0060914 heart formation GO:0061323 cell proliferation involved in heart morphogenesis GO:0061564 axon development GO:0070997 neuron death GO:0071383 cellular response to steroid hormone stimulus GO:0071384 cellular response to corticosteroid stimulus GO:0071385 cellular response to glucocorticoid stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071611 granulocyte colony-stimulating factor production GO:0071655 regulation of granulocyte colony-stimulating factor production GO:0071657 positive regulation of granulocyte colony-stimulating factor production GO:0071706 tumor necrosis factor superfamily cytokine production GO:0072132 mesenchyme morphogenesis GO:0090074 negative regulation of protein homodimerization activity GO:0090087 regulation of peptide transport GO:0090090 negative regulation of canonical Wnt signaling pathway GO:0090276 regulation of peptide hormone secretion GO:0090277 positive regulation of peptide hormone secretion GO:0097485 neuron projection guidance GO:0097696 STAT cascade GO:0198738 cell-cell signaling by wnt GO:1901214 regulation of neuron death GO:1901215 negative regulation of neuron death GO:1901256 regulation of macrophage colony-stimulating factor production GO:1901258 positive regulation of macrophage colony-stimulating factor production GO:1901342 regulation of vasculature development GO:1901983 regulation of protein acetylation GO:1901985 positive regulation of protein acetylation GO:1902275 regulation of chromatin organization GO:1903532 positive regulation of secretion by cell GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production GO:1904018 positive regulation of vasculature development GO:1904892 regulation of STAT cascade GO:1904894 positive regulation of STAT cascade GO:1904951 positive regulation of establishment of protein localization GO:1905269 positive regulation of chromatin organization GO:2000027 regulation of organ morphogenesis GO:2000136 regulation of cell proliferation involved in heart morphogenesis GO:2000756 regulation of peptidyl-lysine acetylation GO:2000758 positive regulation of peptidyl-lysine acetylation GO:2000826 regulation of heart morphogenesis |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001085 RNA polymerase II transcription factor binding GO:0001102 RNA polymerase II activating transcription factor binding GO:0001104 RNA polymerase II transcription cofactor activity GO:0001105 RNA polymerase II transcription coactivator activity GO:0001158 enhancer sequence-specific DNA binding GO:0001159 core promoter proximal region DNA binding GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003682 chromatin binding GO:0003713 transcription coactivator activity GO:0008134 transcription factor binding GO:0016922 ligand-dependent nuclear receptor binding GO:0030331 estrogen receptor binding GO:0033613 activating transcription factor binding GO:0035257 nuclear hormone receptor binding GO:0035258 steroid hormone receptor binding GO:0035326 enhancer binding GO:0043425 bHLH transcription factor binding GO:0051427 hormone receptor binding GO:0098811 transcriptional repressor activity, RNA polymerase II activating transcription factor binding |
Cellular Component | - |
KEGG |
hsa04550 Signaling pathways regulating pluripotency of stem cells |
Reactome |
R-HSA-400508: Incretin synthesis, secretion, and inactivation R-HSA-392499: Metabolism of proteins R-HSA-2980736: Peptide hormone metabolism R-HSA-400511: Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
Summary | |
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Symbol | ISL1 |
Name | ISL LIM homeobox 1 |
Aliases | Isl-1; ISLET1; ISL1 transcription factor, LIM/homeodomain, (islet-1); ISL1 transcription factor, LIM/homeodo ...... |
Chromosomal Location | 5q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ISL1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ISL1 |
Name | ISL LIM homeobox 1 |
Aliases | Isl-1; ISLET1; ISL1 transcription factor, LIM/homeodomain, (islet-1); ISL1 transcription factor, LIM/homeodo ...... |
Chromosomal Location | 5q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ISL1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ISL1 |
Name | ISL LIM homeobox 1 |
Aliases | Isl-1; ISLET1; ISL1 transcription factor, LIM/homeodomain, (islet-1); ISL1 transcription factor, LIM/homeodo ...... |
Chromosomal Location | 5q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ISL1 in various data sets.
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Points in the above scatter plot represent the mutation difference of ISL1 in various data sets.
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Summary | |
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Symbol | ISL1 |
Name | ISL LIM homeobox 1 |
Aliases | Isl-1; ISLET1; ISL1 transcription factor, LIM/homeodomain, (islet-1); ISL1 transcription factor, LIM/homeodo ...... |
Chromosomal Location | 5q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ISL1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ISL1 |
Name | ISL LIM homeobox 1 |
Aliases | Isl-1; ISLET1; ISL1 transcription factor, LIM/homeodomain, (islet-1); ISL1 transcription factor, LIM/homeodo ...... |
Chromosomal Location | 5q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ISL1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ISL1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ISL1 |
Name | ISL LIM homeobox 1 |
Aliases | Isl-1; ISLET1; ISL1 transcription factor, LIM/homeodomain, (islet-1); ISL1 transcription factor, LIM/homeodo ...... |
Chromosomal Location | 5q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ISL1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ISL1 |
Name | ISL LIM homeobox 1 |
Aliases | Isl-1; ISLET1; ISL1 transcription factor, LIM/homeodomain, (islet-1); ISL1 transcription factor, LIM/homeodo ...... |
Chromosomal Location | 5q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ISL1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ISL1 |
Name | ISL LIM homeobox 1 |
Aliases | Isl-1; ISLET1; ISL1 transcription factor, LIM/homeodomain, (islet-1); ISL1 transcription factor, LIM/homeodo ...... |
Chromosomal Location | 5q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ISL1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ISL1 |
Name | ISL LIM homeobox 1 |
Aliases | Isl-1; ISLET1; ISL1 transcription factor, LIM/homeodomain, (islet-1); ISL1 transcription factor, LIM/homeodo ...... |
Chromosomal Location | 5q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ISL1 collected from DrugBank database. |
There is no record. |