Summary | |
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Symbol | ITGA1 |
Name | integrin, alpha 1 |
Aliases | VLA1; CD49a; CD49 antigen-like family member A; VLA-1; laminin and collagen receptor; very late activation p ...... |
Chromosomal Location | 5q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Domain |
PF01839 FG-GAP repeat PF08441 Integrin alpha PF00092 von Willebrand factor type A domain |
Function |
Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. |
Biological Process |
GO:0000187 activation of MAPK activity GO:0003012 muscle system process GO:0003013 circulatory system process GO:0003018 vascular process in circulatory system GO:0006470 protein dephosphorylation GO:0006936 muscle contraction GO:0007160 cell-matrix adhesion GO:0007173 epidermal growth factor receptor signaling pathway GO:0007229 integrin-mediated signaling pathway GO:0008015 blood circulation GO:0010921 regulation of phosphatase activity GO:0010922 positive regulation of phosphatase activity GO:0016311 dephosphorylation GO:0030198 extracellular matrix organization GO:0030593 neutrophil chemotaxis GO:0030595 leukocyte chemotaxis GO:0031589 cell-substrate adhesion GO:0032147 activation of protein kinase activity GO:0032516 positive regulation of phosphoprotein phosphatase activity GO:0033674 positive regulation of kinase activity GO:0035150 regulation of tube size GO:0035303 regulation of dephosphorylation GO:0035304 regulation of protein dephosphorylation GO:0035306 positive regulation of dephosphorylation GO:0035307 positive regulation of protein dephosphorylation GO:0038127 ERBB signaling pathway GO:0042058 regulation of epidermal growth factor receptor signaling pathway GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway GO:0042311 vasodilation GO:0043062 extracellular structure organization GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043523 regulation of neuron apoptotic process GO:0043525 positive regulation of neuron apoptotic process GO:0043666 regulation of phosphoprotein phosphatase activity GO:0045123 cellular extravasation GO:0045860 positive regulation of protein kinase activity GO:0050880 regulation of blood vessel size GO:0050900 leukocyte migration GO:0051402 neuron apoptotic process GO:0060326 cell chemotaxis GO:0070997 neuron death GO:0071621 granulocyte chemotaxis GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0090066 regulation of anatomical structure size GO:0097529 myeloid leukocyte migration GO:0097530 granulocyte migration GO:1901184 regulation of ERBB signaling pathway GO:1901185 negative regulation of ERBB signaling pathway GO:1901214 regulation of neuron death GO:1901216 positive regulation of neuron death GO:1990266 neutrophil migration |
Molecular Function |
GO:0005518 collagen binding GO:0019902 phosphatase binding GO:0019903 protein phosphatase binding GO:0098631 protein binding involved in cell adhesion GO:0098634 protein binding involved in cell-matrix adhesion GO:0098639 collagen binding involved in cell-matrix adhesion |
Cellular Component |
GO:0001669 acrosomal vesicle GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0008305 integrin complex GO:0009897 external side of plasma membrane GO:0030055 cell-substrate junction GO:0030141 secretory granule GO:0034665 integrin alpha1-beta1 complex GO:0043025 neuronal cell body GO:0043204 perikaryon GO:0043235 receptor complex GO:0044297 cell body GO:0045121 membrane raft GO:0045178 basal part of cell GO:0097223 sperm part GO:0098552 side of membrane GO:0098589 membrane region GO:0098636 protein complex involved in cell adhesion GO:0098802 plasma membrane receptor complex GO:0098857 membrane microdomain GO:0099503 secretory vesicle |
KEGG |
hsa04151 PI3K-Akt signaling pathway hsa04510 Focal adhesion hsa04512 ECM-receptor interaction hsa04640 Hematopoietic cell lineage hsa04810 Regulation of actin cytoskeleton |
Reactome |
R-HSA-422475: Axon guidance R-HSA-447041: CHL1 interactions R-HSA-1266738: Developmental Biology R-HSA-1474244: Extracellular matrix organization R-HSA-109582: Hemostasis R-HSA-216083: Integrin cell surface interactions R-HSA-373760: L1CAM interactions R-HSA-3000157: Laminin interactions R-HSA-397014: Muscle contraction R-HSA-416700: Other semaphorin interactions R-HSA-75892: Platelet Adhesion to exposed collagen R-HSA-373755: Semaphorin interactions R-HSA-445355: Smooth Muscle Contraction |
Summary | |
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Symbol | ITGA1 |
Name | integrin, alpha 1 |
Aliases | VLA1; CD49a; CD49 antigen-like family member A; VLA-1; laminin and collagen receptor; very late activation p ...... |
Chromosomal Location | 5q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ITGA1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ITGA1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | ITGA1 |
Name | integrin, alpha 1 |
Aliases | VLA1; CD49a; CD49 antigen-like family member A; VLA-1; laminin and collagen receptor; very late activation p ...... |
Chromosomal Location | 5q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ITGA1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ITGA1 |
Name | integrin, alpha 1 |
Aliases | VLA1; CD49a; CD49 antigen-like family member A; VLA-1; laminin and collagen receptor; very late activation p ...... |
Chromosomal Location | 5q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ITGA1 in various data sets.
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Points in the above scatter plot represent the mutation difference of ITGA1 in various data sets.
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Summary | |
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Symbol | ITGA1 |
Name | integrin, alpha 1 |
Aliases | VLA1; CD49a; CD49 antigen-like family member A; VLA-1; laminin and collagen receptor; very late activation p ...... |
Chromosomal Location | 5q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ITGA1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ITGA1 |
Name | integrin, alpha 1 |
Aliases | VLA1; CD49a; CD49 antigen-like family member A; VLA-1; laminin and collagen receptor; very late activation p ...... |
Chromosomal Location | 5q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ITGA1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ITGA1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ITGA1 |
Name | integrin, alpha 1 |
Aliases | VLA1; CD49a; CD49 antigen-like family member A; VLA-1; laminin and collagen receptor; very late activation p ...... |
Chromosomal Location | 5q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ITGA1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ITGA1 |
Name | integrin, alpha 1 |
Aliases | VLA1; CD49a; CD49 antigen-like family member A; VLA-1; laminin and collagen receptor; very late activation p ...... |
Chromosomal Location | 5q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ITGA1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ITGA1 |
Name | integrin, alpha 1 |
Aliases | VLA1; CD49a; CD49 antigen-like family member A; VLA-1; laminin and collagen receptor; very late activation p ...... |
Chromosomal Location | 5q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ITGA1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ITGA1 |
Name | integrin, alpha 1 |
Aliases | VLA1; CD49a; CD49 antigen-like family member A; VLA-1; laminin and collagen receptor; very late activation p ...... |
Chromosomal Location | 5q11.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ITGA1 collected from DrugBank database. |
There is no record. |