Summary | |
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Symbol | ITGA4 |
Name | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) |
Aliases | CD49d; 269C wild type; CD49 antigen-like family member D; VLA-4 subunit alpha; antigen CD49D, alpha-4 subuni ...... |
Chromosomal Location | 2q31-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Domain |
PF01839 FG-GAP repeat PF08441 Integrin alpha |
Function |
Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). |
Biological Process |
GO:0001667 ameboidal-type cell migration GO:0001704 formation of primary germ layer GO:0001706 endoderm formation GO:0002521 leukocyte differentiation GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002691 regulation of cellular extravasation GO:0002693 positive regulation of cellular extravasation GO:0003366 cell-matrix adhesion involved in ameboidal cell migration GO:0006898 receptor-mediated endocytosis GO:0007159 leukocyte cell-cell adhesion GO:0007160 cell-matrix adhesion GO:0007229 integrin-mediated signaling pathway GO:0007369 gastrulation GO:0007492 endoderm development GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030098 lymphocyte differentiation GO:0030183 B cell differentiation GO:0030198 extracellular matrix organization GO:0030335 positive regulation of cell migration GO:0031589 cell-substrate adhesion GO:0032091 negative regulation of protein binding GO:0034113 heterotypic cell-cell adhesion GO:0034446 substrate adhesion-dependent cell spreading GO:0035987 endodermal cell differentiation GO:0040017 positive regulation of locomotion GO:0042113 B cell activation GO:0043062 extracellular structure organization GO:0043113 receptor clustering GO:0043393 regulation of protein binding GO:0043496 regulation of protein homodimerization activity GO:0045123 cellular extravasation GO:0045785 positive regulation of cell adhesion GO:0050900 leukocyte migration GO:0050901 leukocyte tethering or rolling GO:0050904 diapedesis GO:0051098 regulation of binding GO:0051100 negative regulation of binding GO:0051272 positive regulation of cellular component movement GO:0051640 organelle localization GO:0051648 vesicle localization GO:0051650 establishment of vesicle localization GO:0051656 establishment of organelle localization GO:0051668 localization within membrane GO:0061756 leukocyte adhesion to vascular endothelial cell GO:0072583 clathrin-dependent endocytosis GO:0072657 protein localization to membrane GO:0072676 lymphocyte migration GO:0072678 T cell migration GO:0090074 negative regulation of protein homodimerization activity GO:0098657 import into cell GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903236 regulation of leukocyte tethering or rolling GO:1903238 positive regulation of leukocyte tethering or rolling GO:1904994 regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1990771 clathrin-dependent extracellular exosome endocytosis GO:2000147 positive regulation of cell motility GO:2000401 regulation of lymphocyte migration GO:2000403 positive regulation of lymphocyte migration GO:2000404 regulation of T cell migration GO:2000406 positive regulation of T cell migration |
Molecular Function |
GO:0001968 fibronectin binding GO:0003823 antigen binding GO:0015026 coreceptor activity GO:0019955 cytokine binding GO:0019956 chemokine binding GO:0019960 C-X3-C chemokine binding GO:0050839 cell adhesion molecule binding GO:1990405 protein antigen binding |
Cellular Component |
GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0008305 integrin complex GO:0030055 cell-substrate junction GO:0034669 integrin alpha4-beta7 complex GO:0043235 receptor complex GO:0098636 protein complex involved in cell adhesion GO:0098802 plasma membrane receptor complex |
KEGG |
hsa04151 PI3K-Akt signaling pathway hsa04510 Focal adhesion hsa04512 ECM-receptor interaction hsa04514 Cell adhesion molecules (CAMs) hsa04640 Hematopoietic cell lineage hsa04670 Leukocyte transendothelial migration hsa04672 Intestinal immune network for IgA production hsa04810 Regulation of actin cytoskeleton |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-1474244: Extracellular matrix organization R-HSA-109582: Hemostasis R-HSA-168256: Immune System R-HSA-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-216083: Integrin cell surface interactions |
Summary | |
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Symbol | ITGA4 |
Name | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) |
Aliases | CD49d; 269C wild type; CD49 antigen-like family member D; VLA-4 subunit alpha; antigen CD49D, alpha-4 subuni ...... |
Chromosomal Location | 2q31-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ITGA4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ITGA4 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | ITGA4 |
Name | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) |
Aliases | CD49d; 269C wild type; CD49 antigen-like family member D; VLA-4 subunit alpha; antigen CD49D, alpha-4 subuni ...... |
Chromosomal Location | 2q31-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ITGA4 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ITGA4 |
Name | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) |
Aliases | CD49d; 269C wild type; CD49 antigen-like family member D; VLA-4 subunit alpha; antigen CD49D, alpha-4 subuni ...... |
Chromosomal Location | 2q31-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ITGA4 in various data sets.
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Points in the above scatter plot represent the mutation difference of ITGA4 in various data sets.
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Summary | |
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Symbol | ITGA4 |
Name | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) |
Aliases | CD49d; 269C wild type; CD49 antigen-like family member D; VLA-4 subunit alpha; antigen CD49D, alpha-4 subuni ...... |
Chromosomal Location | 2q31-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ITGA4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ITGA4 |
Name | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) |
Aliases | CD49d; 269C wild type; CD49 antigen-like family member D; VLA-4 subunit alpha; antigen CD49D, alpha-4 subuni ...... |
Chromosomal Location | 2q31-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ITGA4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ITGA4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ITGA4 |
Name | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) |
Aliases | CD49d; 269C wild type; CD49 antigen-like family member D; VLA-4 subunit alpha; antigen CD49D, alpha-4 subuni ...... |
Chromosomal Location | 2q31-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ITGA4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ITGA4 |
Name | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) |
Aliases | CD49d; 269C wild type; CD49 antigen-like family member D; VLA-4 subunit alpha; antigen CD49D, alpha-4 subuni ...... |
Chromosomal Location | 2q31-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ITGA4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ITGA4 |
Name | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) |
Aliases | CD49d; 269C wild type; CD49 antigen-like family member D; VLA-4 subunit alpha; antigen CD49D, alpha-4 subuni ...... |
Chromosomal Location | 2q31-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ITGA4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ITGA4 |
Name | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) |
Aliases | CD49d; 269C wild type; CD49 antigen-like family member D; VLA-4 subunit alpha; antigen CD49D, alpha-4 subuni ...... |
Chromosomal Location | 2q31-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ITGA4 collected from DrugBank database. |
Details on drugs targeting ITGA4.
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