Summary | |
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Symbol | ITGA5 |
Name | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) |
Aliases | CD49e; FNRA; VLA-5; VLA5A; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronecti ...... |
Chromosomal Location | 12q11-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion Cell surface |
Domain |
PF01839 FG-GAP repeat PF08441 Integrin alpha |
Function |
Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ; FUNCTION: (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus. ; FUNCTION: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19. ; FUNCTION: (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. |
Biological Process |
GO:0001525 angiogenesis GO:0001704 formation of primary germ layer GO:0001706 endoderm formation GO:0002011 morphogenesis of an epithelial sheet GO:0002040 sprouting angiogenesis GO:0007044 cell-substrate junction assembly GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007159 leukocyte cell-cell adhesion GO:0007229 integrin-mediated signaling pathway GO:0007369 gastrulation GO:0007492 endoderm development GO:0007611 learning or memory GO:0007613 memory GO:0010810 regulation of cell-substrate adhesion GO:0010811 positive regulation of cell-substrate adhesion GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0019058 viral life cycle GO:0030198 extracellular matrix organization GO:0030260 entry into host cell GO:0030335 positive regulation of cell migration GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0031589 cell-substrate adhesion GO:0033627 cell adhesion mediated by integrin GO:0033631 cell-cell adhesion mediated by integrin GO:0034113 heterotypic cell-cell adhesion GO:0034329 cell junction assembly GO:0034330 cell junction organization GO:0035313 wound healing, spreading of epidermal cells GO:0035987 endodermal cell differentiation GO:0040017 positive regulation of locomotion GO:0043062 extracellular structure organization GO:0043276 anoikis GO:0044319 wound healing, spreading of cells GO:0044409 entry into host GO:0044708 single-organism behavior GO:0045765 regulation of angiogenesis GO:0045766 positive regulation of angiogenesis GO:0045785 positive regulation of cell adhesion GO:0046718 viral entry into host cell GO:0048010 vascular endothelial growth factor receptor signaling pathway GO:0048514 blood vessel morphogenesis GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050890 cognition GO:0050900 leukocyte migration GO:0051272 positive regulation of cellular component movement GO:0051701 interaction with host GO:0051806 entry into cell of other organism involved in symbiotic interaction GO:0051828 entry into other organism involved in symbiotic interaction GO:0090287 regulation of cellular response to growth factor stimulus GO:0090504 epiboly GO:0090505 epiboly involved in wound healing GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules GO:1901342 regulation of vasculature development GO:1903670 regulation of sprouting angiogenesis GO:1903672 positive regulation of sprouting angiogenesis GO:1904018 positive regulation of vasculature development GO:2000147 positive regulation of cell motility GO:2000209 regulation of anoikis GO:2000811 negative regulation of anoikis |
Molecular Function |
GO:0001618 virus receptor activity GO:0005126 cytokine receptor binding GO:0005154 epidermal growth factor receptor binding GO:0005161 platelet-derived growth factor receptor binding GO:0005172 vascular endothelial growth factor receptor binding GO:0005178 integrin binding GO:0043184 vascular endothelial growth factor receptor 2 binding GO:0050839 cell adhesion molecule binding GO:0070851 growth factor receptor binding |
Cellular Component |
GO:0001726 ruffle GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0008305 integrin complex GO:0009897 external side of plasma membrane GO:0030055 cell-substrate junction GO:0031252 cell leading edge GO:0031253 cell projection membrane GO:0031256 leading edge membrane GO:0032587 ruffle membrane GO:0043235 receptor complex GO:0071062 alphav-beta3 integrin-vitronectin complex GO:0098552 side of membrane GO:0098636 protein complex involved in cell adhesion GO:0098802 plasma membrane receptor complex |
KEGG |
hsa04145 Phagosome hsa04151 PI3K-Akt signaling pathway hsa04510 Focal adhesion hsa04512 ECM-receptor interaction hsa04640 Hematopoietic cell lineage hsa04810 Regulation of actin cytoskeleton |
Reactome |
R-HSA-422475: Axon guidance R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-1266738: Developmental Biology R-HSA-1566948: Elastic fibre formation R-HSA-1474244: Extracellular matrix organization R-HSA-1566977: Fibronectin matrix formation R-HSA-109582: Hemostasis R-HSA-216083: Integrin cell surface interactions R-HSA-373760: L1CAM interactions R-HSA-445144: Signal transduction by L1 |
Summary | |
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Symbol | ITGA5 |
Name | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) |
Aliases | CD49e; FNRA; VLA-5; VLA5A; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronecti ...... |
Chromosomal Location | 12q11-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ITGA5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | ITGA5 |
Name | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) |
Aliases | CD49e; FNRA; VLA-5; VLA5A; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronecti ...... |
Chromosomal Location | 12q11-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ITGA5 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ITGA5 |
Name | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) |
Aliases | CD49e; FNRA; VLA-5; VLA5A; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronecti ...... |
Chromosomal Location | 12q11-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ITGA5 in various data sets.
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Points in the above scatter plot represent the mutation difference of ITGA5 in various data sets.
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Summary | |
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Symbol | ITGA5 |
Name | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) |
Aliases | CD49e; FNRA; VLA-5; VLA5A; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronecti ...... |
Chromosomal Location | 12q11-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ITGA5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ITGA5 |
Name | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) |
Aliases | CD49e; FNRA; VLA-5; VLA5A; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronecti ...... |
Chromosomal Location | 12q11-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ITGA5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ITGA5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ITGA5 |
Name | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) |
Aliases | CD49e; FNRA; VLA-5; VLA5A; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronecti ...... |
Chromosomal Location | 12q11-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ITGA5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ITGA5 |
Name | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) |
Aliases | CD49e; FNRA; VLA-5; VLA5A; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronecti ...... |
Chromosomal Location | 12q11-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ITGA5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ITGA5 |
Name | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) |
Aliases | CD49e; FNRA; VLA-5; VLA5A; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronecti ...... |
Chromosomal Location | 12q11-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ITGA5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ITGA5 |
Name | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) |
Aliases | CD49e; FNRA; VLA-5; VLA5A; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronecti ...... |
Chromosomal Location | 12q11-q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ITGA5 collected from DrugBank database. |
Details on drugs targeting ITGA5.
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