Browse ITGA8

Summary
SymbolITGA8
Nameintegrin, alpha 8
Aliases Integrin alpha-8
Chromosomal Location10p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane Single-pass type I membrane protein Cell membrane
Domain PF01839 FG-GAP repeat
PF00357 Integrin alpha cytoplasmic region
PF08441 Integrin alpha
Function

Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.

> Gene Ontology
 
Biological Process GO:0001655 urogenital system development
GO:0001656 metanephros development
GO:0001704 formation of primary germ layer
GO:0001707 mesoderm formation
GO:0001822 kidney development
GO:0007160 cell-matrix adhesion
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007369 gastrulation
GO:0007423 sensory organ development
GO:0007498 mesoderm development
GO:0007611 learning or memory
GO:0007613 memory
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0030198 extracellular matrix organization
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0031589 cell-substrate adhesion
GO:0034446 substrate adhesion-dependent cell spreading
GO:0042471 ear morphogenesis
GO:0042472 inner ear morphogenesis
GO:0042692 muscle cell differentiation
GO:0043062 extracellular structure organization
GO:0043583 ear development
GO:0044708 single-organism behavior
GO:0048332 mesoderm morphogenesis
GO:0048333 mesodermal cell differentiation
GO:0048562 embryonic organ morphogenesis
GO:0048568 embryonic organ development
GO:0048745 smooth muscle tissue development
GO:0048839 inner ear development
GO:0050890 cognition
GO:0051145 smooth muscle cell differentiation
GO:0060537 muscle tissue development
GO:0071559 response to transforming growth factor beta
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0072001 renal system development
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090287 regulation of cellular response to growth factor stimulus
GO:0090596 sensory organ morphogenesis
GO:1903844 regulation of cellular response to transforming growth factor beta stimulus
GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus
GO:2000721 positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
Molecular Function -
Cellular Component GO:0005924 cell-substrate adherens junction
GO:0005925 focal adhesion
GO:0008305 integrin complex
GO:0014069 postsynaptic density
GO:0030055 cell-substrate junction
GO:0031252 cell leading edge
GO:0031253 cell projection membrane
GO:0031256 leading edge membrane
GO:0032589 neuron projection membrane
GO:0032590 dendrite membrane
GO:0032591 dendritic spine membrane
GO:0034678 integrin alpha8-beta1 complex
GO:0043025 neuronal cell body
GO:0043204 perikaryon
GO:0043235 receptor complex
GO:0044297 cell body
GO:0045177 apical part of cell
GO:0060076 excitatory synapse
GO:0097060 synaptic membrane
GO:0098636 protein complex involved in cell adhesion
GO:0098794 postsynapse
GO:0098802 plasma membrane receptor complex
GO:0099572 postsynaptic specialization
> KEGG and Reactome Pathway
 
KEGG hsa04151 PI3K-Akt signaling pathway
hsa04510 Focal adhesion
hsa04512 ECM-receptor interaction
hsa04514 Cell adhesion molecules (CAMs)
hsa04810 Regulation of actin cytoskeleton
Reactome R-HSA-3000178: ECM proteoglycans
R-HSA-1566948: Elastic fibre formation
R-HSA-1474244: Extracellular matrix organization
R-HSA-216083: Integrin cell surface interactions
R-HSA-2129379: Molecules associated with elastic fibres
Summary
SymbolITGA8
Nameintegrin, alpha 8
Aliases Integrin alpha-8
Chromosomal Location10p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ITGA8 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolITGA8
Nameintegrin, alpha 8
Aliases Integrin alpha-8
Chromosomal Location10p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ITGA8 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolITGA8
Nameintegrin, alpha 8
Aliases Integrin alpha-8
Chromosomal Location10p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ITGA8 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.7710.0216
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.9630.0946
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.6410.186
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2590.605
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.8470.661
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.4720.827
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3490.457
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.860.244
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0060.994
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.4540.593
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.3460.21
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.340.0794
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ITGA8 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.76.8-3.11
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.78.5-4.80.66
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211723.85.917.90.197
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8637.5037.50.209
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.49.16.31
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.33.71.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.17.71.41
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolITGA8
Nameintegrin, alpha 8
Aliases Integrin alpha-8
Chromosomal Location10p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ITGA8. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolITGA8
Nameintegrin, alpha 8
Aliases Integrin alpha-8
Chromosomal Location10p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ITGA8. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ITGA8.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolITGA8
Nameintegrin, alpha 8
Aliases Integrin alpha-8
Chromosomal Location10p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ITGA8. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolITGA8
Nameintegrin, alpha 8
Aliases Integrin alpha-8
Chromosomal Location10p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ITGA8 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolITGA8
Nameintegrin, alpha 8
Aliases Integrin alpha-8
Chromosomal Location10p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ITGA8 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolITGA8
Nameintegrin, alpha 8
Aliases Integrin alpha-8
Chromosomal Location10p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ITGA8 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.