Summary | |
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Symbol | ITGA9 |
Name | integrin, alpha 9 |
Aliases | RLC; ITGA4L; ALPHA-RLC; integrin, alpha 4-like; integrin alpha-RLC; Integrin alpha-9 |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Single-pass type I membrane protein |
Domain |
PF01839 FG-GAP repeat PF08441 Integrin alpha |
Function |
Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. |
Biological Process |
GO:0007229 integrin-mediated signaling pathway GO:0030198 extracellular matrix organization GO:0030593 neutrophil chemotaxis GO:0030595 leukocyte chemotaxis GO:0043062 extracellular structure organization GO:0050900 leukocyte migration GO:0060326 cell chemotaxis GO:0071621 granulocyte chemotaxis GO:0097529 myeloid leukocyte migration GO:0097530 granulocyte migration GO:1990266 neutrophil migration |
Molecular Function |
GO:0005518 collagen binding GO:0043236 laminin binding GO:0050840 extracellular matrix binding |
Cellular Component |
GO:0008305 integrin complex GO:0009925 basal plasma membrane GO:0016323 basolateral plasma membrane GO:0034679 integrin alpha9-beta1 complex GO:0043235 receptor complex GO:0045178 basal part of cell GO:0098636 protein complex involved in cell adhesion GO:0098802 plasma membrane receptor complex |
KEGG |
hsa04151 PI3K-Akt signaling pathway hsa04510 Focal adhesion hsa04512 ECM-receptor interaction hsa04514 Cell adhesion molecules (CAMs) hsa04810 Regulation of actin cytoskeleton |
Reactome |
R-HSA-422475: Axon guidance R-HSA-1266738: Developmental Biology R-HSA-3000178: ECM proteoglycans R-HSA-1474244: Extracellular matrix organization R-HSA-216083: Integrin cell surface interactions R-HSA-373760: L1CAM interactions R-HSA-445144: Signal transduction by L1 |
Summary | |
---|---|
Symbol | ITGA9 |
Name | integrin, alpha 9 |
Aliases | RLC; ITGA4L; ALPHA-RLC; integrin, alpha 4-like; integrin alpha-RLC; Integrin alpha-9 |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ITGA9 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ITGA9 |
Name | integrin, alpha 9 |
Aliases | RLC; ITGA4L; ALPHA-RLC; integrin, alpha 4-like; integrin alpha-RLC; Integrin alpha-9 |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ITGA9 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ITGA9 |
Name | integrin, alpha 9 |
Aliases | RLC; ITGA4L; ALPHA-RLC; integrin, alpha 4-like; integrin alpha-RLC; Integrin alpha-9 |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ITGA9 in various data sets.
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Points in the above scatter plot represent the mutation difference of ITGA9 in various data sets.
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Summary | |
---|---|
Symbol | ITGA9 |
Name | integrin, alpha 9 |
Aliases | RLC; ITGA4L; ALPHA-RLC; integrin, alpha 4-like; integrin alpha-RLC; Integrin alpha-9 |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ITGA9. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ITGA9 |
Name | integrin, alpha 9 |
Aliases | RLC; ITGA4L; ALPHA-RLC; integrin, alpha 4-like; integrin alpha-RLC; Integrin alpha-9 |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ITGA9. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ITGA9. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | ITGA9 |
Name | integrin, alpha 9 |
Aliases | RLC; ITGA4L; ALPHA-RLC; integrin, alpha 4-like; integrin alpha-RLC; Integrin alpha-9 |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ITGA9. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ITGA9 |
Name | integrin, alpha 9 |
Aliases | RLC; ITGA4L; ALPHA-RLC; integrin, alpha 4-like; integrin alpha-RLC; Integrin alpha-9 |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ITGA9 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ITGA9 |
Name | integrin, alpha 9 |
Aliases | RLC; ITGA4L; ALPHA-RLC; integrin, alpha 4-like; integrin alpha-RLC; Integrin alpha-9 |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ITGA9 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ITGA9 |
Name | integrin, alpha 9 |
Aliases | RLC; ITGA4L; ALPHA-RLC; integrin, alpha 4-like; integrin alpha-RLC; Integrin alpha-9 |
Chromosomal Location | 3p21.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ITGA9 collected from DrugBank database. |
There is no record. |