Summary | |
---|---|
Symbol | ITGAE |
Name | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) |
Aliases | CD103; HUMINAE; HML-1 antigen; antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide; integri ...... |
Chromosomal Location | 17p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Domain |
PF01839 FG-GAP repeat PF00357 Integrin alpha cytoplasmic region PF08441 Integrin alpha PF00092 von Willebrand factor type A domain |
Function |
Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. |
Biological Process |
GO:0007229 integrin-mediated signaling pathway GO:0030198 extracellular matrix organization GO:0043062 extracellular structure organization |
Molecular Function | - |
Cellular Component |
GO:0008305 integrin complex GO:0009897 external side of plasma membrane GO:0043235 receptor complex GO:0098552 side of membrane GO:0098636 protein complex involved in cell adhesion GO:0098802 plasma membrane receptor complex |
KEGG |
hsa04810 Regulation of actin cytoskeleton |
Reactome |
R-HSA-1474244: Extracellular matrix organization R-HSA-216083: Integrin cell surface interactions |
Summary | |
---|---|
Symbol | ITGAE |
Name | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) |
Aliases | CD103; HUMINAE; HML-1 antigen; antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide; integri ...... |
Chromosomal Location | 17p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ITGAE and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ITGAE and anti-tumor immunity in human cancer.
|
Summary | |
---|---|
Symbol | ITGAE |
Name | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) |
Aliases | CD103; HUMINAE; HML-1 antigen; antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide; integri ...... |
Chromosomal Location | 17p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of ITGAE in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | ITGAE |
Name | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) |
Aliases | CD103; HUMINAE; HML-1 antigen; antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide; integri ...... |
Chromosomal Location | 17p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ITGAE in various data sets.
|
Points in the above scatter plot represent the mutation difference of ITGAE in various data sets.
|
Summary | |
---|---|
Symbol | ITGAE |
Name | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) |
Aliases | CD103; HUMINAE; HML-1 antigen; antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide; integri ...... |
Chromosomal Location | 17p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ITGAE. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ITGAE |
Name | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) |
Aliases | CD103; HUMINAE; HML-1 antigen; antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide; integri ...... |
Chromosomal Location | 17p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ITGAE. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ITGAE. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | ITGAE |
Name | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) |
Aliases | CD103; HUMINAE; HML-1 antigen; antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide; integri ...... |
Chromosomal Location | 17p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ITGAE. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ITGAE |
Name | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) |
Aliases | CD103; HUMINAE; HML-1 antigen; antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide; integri ...... |
Chromosomal Location | 17p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ITGAE expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ITGAE |
Name | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) |
Aliases | CD103; HUMINAE; HML-1 antigen; antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide; integri ...... |
Chromosomal Location | 17p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ITGAE and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ITGAE |
Name | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) |
Aliases | CD103; HUMINAE; HML-1 antigen; antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide; integri ...... |
Chromosomal Location | 17p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ITGAE collected from DrugBank database. |
There is no record. |