Summary | |
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Symbol | ITGB4 |
Name | integrin, beta 4 |
Aliases | CD104; CD104 antigen; integrin beta-4 subunit; CD antigen CD104; Integrin beta-4 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Note=Colocalizes with DST at the leading edge of migrating keratinocytes. |
Domain |
PF03160 Calx-beta domain PF07974 EGF-like domain PF00041 Fibronectin type III domain PF07965 Integrin beta tail domain PF00362 Integrin beta chain VWA domain PF17205 Integrin plexin domain |
Function |
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). |
Biological Process |
GO:0001655 urogenital system development GO:0001704 formation of primary germ layer GO:0001707 mesoderm formation GO:0006914 autophagy GO:0007044 cell-substrate junction assembly GO:0007160 cell-matrix adhesion GO:0007229 integrin-mediated signaling pathway GO:0007369 gastrulation GO:0007498 mesoderm development GO:0030198 extracellular matrix organization GO:0031581 hemidesmosome assembly GO:0031589 cell-substrate adhesion GO:0034329 cell junction assembly GO:0034330 cell junction organization GO:0035878 nail development GO:0042475 odontogenesis of dentin-containing tooth GO:0042476 odontogenesis GO:0043062 extracellular structure organization GO:0043588 skin development GO:0048332 mesoderm morphogenesis GO:0048333 mesodermal cell differentiation GO:0048565 digestive tract development GO:0048736 appendage development GO:0055123 digestive system development GO:0060173 limb development GO:0072001 renal system development GO:0097186 amelogenesis |
Molecular Function |
GO:0001664 G-protein coupled receptor binding GO:0005520 insulin-like growth factor binding GO:0019838 growth factor binding GO:0031994 insulin-like growth factor I binding GO:0038132 neuregulin binding |
Cellular Component |
GO:0008305 integrin complex GO:0030055 cell-substrate junction GO:0030056 hemidesmosome GO:0031252 cell leading edge GO:0043235 receptor complex GO:0098636 protein complex involved in cell adhesion GO:0098802 plasma membrane receptor complex |
KEGG |
hsa04151 PI3K-Akt signaling pathway hsa04510 Focal adhesion hsa04512 ECM-receptor interaction hsa04810 Regulation of actin cytoskeleton |
Reactome |
R-HSA-2022090: Assembly of collagen fibrils and other multimeric structures R-HSA-446728: Cell junction organization R-HSA-1500931: Cell-Cell communication R-HSA-1474290: Collagen formation R-HSA-1474244: Extracellular matrix organization R-HSA-3000157: Laminin interactions R-HSA-3000171: Non-integrin membrane-ECM interactions R-HSA-3000170: Syndecan interactions R-HSA-446107: Type I hemidesmosome assembly |
Summary | |
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Symbol | ITGB4 |
Name | integrin, beta 4 |
Aliases | CD104; CD104 antigen; integrin beta-4 subunit; CD antigen CD104; Integrin beta-4 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ITGB4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | ITGB4 |
Name | integrin, beta 4 |
Aliases | CD104; CD104 antigen; integrin beta-4 subunit; CD antigen CD104; Integrin beta-4 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ITGB4 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | ITGB4 |
Name | integrin, beta 4 |
Aliases | CD104; CD104 antigen; integrin beta-4 subunit; CD antigen CD104; Integrin beta-4 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ITGB4 in various data sets.
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Points in the above scatter plot represent the mutation difference of ITGB4 in various data sets.
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Summary | |
---|---|
Symbol | ITGB4 |
Name | integrin, beta 4 |
Aliases | CD104; CD104 antigen; integrin beta-4 subunit; CD antigen CD104; Integrin beta-4 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ITGB4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ITGB4 |
Name | integrin, beta 4 |
Aliases | CD104; CD104 antigen; integrin beta-4 subunit; CD antigen CD104; Integrin beta-4 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ITGB4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ITGB4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ITGB4 |
Name | integrin, beta 4 |
Aliases | CD104; CD104 antigen; integrin beta-4 subunit; CD antigen CD104; Integrin beta-4 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ITGB4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ITGB4 |
Name | integrin, beta 4 |
Aliases | CD104; CD104 antigen; integrin beta-4 subunit; CD antigen CD104; Integrin beta-4 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ITGB4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ITGB4 |
Name | integrin, beta 4 |
Aliases | CD104; CD104 antigen; integrin beta-4 subunit; CD antigen CD104; Integrin beta-4 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ITGB4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ITGB4 |
Name | integrin, beta 4 |
Aliases | CD104; CD104 antigen; integrin beta-4 subunit; CD antigen CD104; Integrin beta-4 |
Chromosomal Location | 17q25.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ITGB4 collected from DrugBank database. |
Details on drugs targeting ITGB4.
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