Summary | |
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Symbol | ITIH3 |
Name | inter-alpha-trypsin inhibitor heavy chain 3 |
Aliases | H3P; pre-alpha (globulin) inhibitor, H3 polypeptide; inter-alpha-trypsin inhibitor heavy chain H3; inter-alp ...... |
Chromosomal Location | 3p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF06668 Inter-alpha-trypsin inhibitor heavy chain C-terminus PF08487 Vault protein inter-alpha-trypsin domain PF00092 von Willebrand factor type A domain |
Function |
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. |
Biological Process |
GO:0002576 platelet degranulation GO:0006022 aminoglycan metabolic process GO:0006887 exocytosis GO:0010466 negative regulation of peptidase activity GO:0010951 negative regulation of endopeptidase activity GO:0030203 glycosaminoglycan metabolic process GO:0030212 hyaluronan metabolic process GO:0045055 regulated exocytosis GO:0045861 negative regulation of proteolysis GO:0051346 negative regulation of hydrolase activity GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:1903510 mucopolysaccharide metabolic process |
Molecular Function |
GO:0004857 enzyme inhibitor activity GO:0004866 endopeptidase inhibitor activity GO:0004867 serine-type endopeptidase inhibitor activity GO:0030414 peptidase inhibitor activity GO:0061134 peptidase regulator activity GO:0061135 endopeptidase regulator activity |
Cellular Component |
GO:0030141 secretory granule GO:0031089 platelet dense granule lumen GO:0031983 vesicle lumen GO:0034774 secretory granule lumen GO:0042827 platelet dense granule GO:0060205 cytoplasmic membrane-bounded vesicle lumen GO:0099503 secretory vesicle |
KEGG | - |
Reactome |
R-HSA-109582: Hemostasis R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-114608: Platelet degranulation R-HSA-76005: Response to elevated platelet cytosolic Ca2+ |
Summary | |
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Symbol | ITIH3 |
Name | inter-alpha-trypsin inhibitor heavy chain 3 |
Aliases | H3P; pre-alpha (globulin) inhibitor, H3 polypeptide; inter-alpha-trypsin inhibitor heavy chain H3; inter-alp ...... |
Chromosomal Location | 3p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ITIH3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | ITIH3 |
Name | inter-alpha-trypsin inhibitor heavy chain 3 |
Aliases | H3P; pre-alpha (globulin) inhibitor, H3 polypeptide; inter-alpha-trypsin inhibitor heavy chain H3; inter-alp ...... |
Chromosomal Location | 3p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ITIH3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ITIH3 |
Name | inter-alpha-trypsin inhibitor heavy chain 3 |
Aliases | H3P; pre-alpha (globulin) inhibitor, H3 polypeptide; inter-alpha-trypsin inhibitor heavy chain H3; inter-alp ...... |
Chromosomal Location | 3p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ITIH3 in various data sets.
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Points in the above scatter plot represent the mutation difference of ITIH3 in various data sets.
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Summary | |
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Symbol | ITIH3 |
Name | inter-alpha-trypsin inhibitor heavy chain 3 |
Aliases | H3P; pre-alpha (globulin) inhibitor, H3 polypeptide; inter-alpha-trypsin inhibitor heavy chain H3; inter-alp ...... |
Chromosomal Location | 3p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ITIH3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ITIH3 |
Name | inter-alpha-trypsin inhibitor heavy chain 3 |
Aliases | H3P; pre-alpha (globulin) inhibitor, H3 polypeptide; inter-alpha-trypsin inhibitor heavy chain H3; inter-alp ...... |
Chromosomal Location | 3p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ITIH3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ITIH3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ITIH3 |
Name | inter-alpha-trypsin inhibitor heavy chain 3 |
Aliases | H3P; pre-alpha (globulin) inhibitor, H3 polypeptide; inter-alpha-trypsin inhibitor heavy chain H3; inter-alp ...... |
Chromosomal Location | 3p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ITIH3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ITIH3 |
Name | inter-alpha-trypsin inhibitor heavy chain 3 |
Aliases | H3P; pre-alpha (globulin) inhibitor, H3 polypeptide; inter-alpha-trypsin inhibitor heavy chain H3; inter-alp ...... |
Chromosomal Location | 3p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ITIH3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ITIH3 |
Name | inter-alpha-trypsin inhibitor heavy chain 3 |
Aliases | H3P; pre-alpha (globulin) inhibitor, H3 polypeptide; inter-alpha-trypsin inhibitor heavy chain H3; inter-alp ...... |
Chromosomal Location | 3p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ITIH3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ITIH3 |
Name | inter-alpha-trypsin inhibitor heavy chain 3 |
Aliases | H3P; pre-alpha (globulin) inhibitor, H3 polypeptide; inter-alpha-trypsin inhibitor heavy chain H3; inter-alp ...... |
Chromosomal Location | 3p21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ITIH3 collected from DrugBank database. |
Details on drugs targeting ITIH3.
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