Summary | |
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Symbol | ITK |
Name | IL2-inducible T-cell kinase |
Aliases | LYK; LPFS1; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; T-cell-specific kinase; homolog of m ...... |
Chromosomal Location | 5q31-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation. |
Domain |
PF00779 BTK motif PF00169 PH domain PF07714 Protein tyrosine kinase PF00017 SH2 domain PF00018 SH3 domain |
Function |
Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281). Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3 (By similarity). |
Biological Process |
GO:0001865 NK T cell differentiation GO:0002250 adaptive immune response GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002521 leukocyte differentiation GO:0002757 immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0006968 cellular defense response GO:0007159 leukocyte cell-cell adhesion GO:0007202 activation of phospholipase C activity GO:0010517 regulation of phospholipase activity GO:0010518 positive regulation of phospholipase activity GO:0010863 positive regulation of phospholipase C activity GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0030098 lymphocyte differentiation GO:0030217 T cell differentiation GO:0032609 interferon-gamma production GO:0032633 interleukin-4 production GO:0038083 peptidyl-tyrosine autophosphorylation GO:0038093 Fc receptor signaling pathway GO:0038095 Fc-epsilon receptor signaling pathway GO:0042110 T cell activation GO:0046631 alpha-beta T cell activation GO:0046632 alpha-beta T cell differentiation GO:0046777 protein autophosphorylation GO:0050851 antigen receptor-mediated signaling pathway GO:0050852 T cell receptor signaling pathway GO:0060191 regulation of lipase activity GO:0060193 positive regulation of lipase activity GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0071593 lymphocyte aggregation GO:1900274 regulation of phospholipase C activity |
Molecular Function |
GO:0004713 protein tyrosine kinase activity GO:0004715 non-membrane spanning protein tyrosine kinase activity |
Cellular Component |
GO:0009898 cytoplasmic side of plasma membrane GO:0019897 extrinsic component of plasma membrane GO:0019898 extrinsic component of membrane GO:0031234 extrinsic component of cytoplasmic side of plasma membrane GO:0098552 side of membrane GO:0098562 cytoplasmic side of membrane |
KEGG |
hsa04062 Chemokine signaling pathway hsa04660 T cell receptor signaling pathway hsa04670 Leukocyte transendothelial migration |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-2871809: FCERI mediated Ca+2 mobilization R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-202433: Generation of second messenger molecules R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-202403: TCR signaling |
Summary | |
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Symbol | ITK |
Name | IL2-inducible T-cell kinase |
Aliases | LYK; LPFS1; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; T-cell-specific kinase; homolog of m ...... |
Chromosomal Location | 5q31-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ITK and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ITK and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | ITK |
Name | IL2-inducible T-cell kinase |
Aliases | LYK; LPFS1; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; T-cell-specific kinase; homolog of m ...... |
Chromosomal Location | 5q31-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ITK in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ITK |
Name | IL2-inducible T-cell kinase |
Aliases | LYK; LPFS1; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; T-cell-specific kinase; homolog of m ...... |
Chromosomal Location | 5q31-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ITK in various data sets.
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Points in the above scatter plot represent the mutation difference of ITK in various data sets.
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Summary | |
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Symbol | ITK |
Name | IL2-inducible T-cell kinase |
Aliases | LYK; LPFS1; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; T-cell-specific kinase; homolog of m ...... |
Chromosomal Location | 5q31-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ITK. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ITK |
Name | IL2-inducible T-cell kinase |
Aliases | LYK; LPFS1; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; T-cell-specific kinase; homolog of m ...... |
Chromosomal Location | 5q31-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ITK. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ITK. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ITK |
Name | IL2-inducible T-cell kinase |
Aliases | LYK; LPFS1; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; T-cell-specific kinase; homolog of m ...... |
Chromosomal Location | 5q31-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ITK. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ITK |
Name | IL2-inducible T-cell kinase |
Aliases | LYK; LPFS1; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; T-cell-specific kinase; homolog of m ...... |
Chromosomal Location | 5q31-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ITK expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ITK |
Name | IL2-inducible T-cell kinase |
Aliases | LYK; LPFS1; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; T-cell-specific kinase; homolog of m ...... |
Chromosomal Location | 5q31-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ITK and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ITK |
Name | IL2-inducible T-cell kinase |
Aliases | LYK; LPFS1; IL-2-inducible T cell kinase; IL-2-inducible T-cell kinase; T-cell-specific kinase; homolog of m ...... |
Chromosomal Location | 5q31-q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ITK collected from DrugBank database. |
Details on drugs targeting ITK.
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