Summary | |
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Symbol | ITPR3 |
Name | inositol 1,4,5-trisphosphate receptor, type 3 |
Aliases | IP3R3; inositol 1,4,5-triphosphate receptor, type 3; insP3R3; type 3 InsP3 receptor; Type 3 inositol 1,4,5-t ...... |
Chromosomal Location | 6p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
Domain |
PF08709 Inositol 1 PF00520 Ion transport protein PF02815 MIR domain PF08454 RyR and IP3R Homology associated PF01365 RIH domain |
Function |
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. |
Biological Process |
GO:0002790 peptide secretion GO:0002791 regulation of peptide secretion GO:0003013 circulatory system process GO:0003015 heart process GO:0006816 calcium ion transport GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007596 blood coagulation GO:0007599 hemostasis GO:0007611 learning or memory GO:0007613 memory GO:0008015 blood circulation GO:0008016 regulation of heart contraction GO:0009306 protein secretion GO:0009914 hormone transport GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010817 regulation of hormone levels GO:0015833 peptide transport GO:0019932 second-messenger-mediated signaling GO:0023061 signal release GO:0030072 peptide hormone secretion GO:0030073 insulin secretion GO:0030168 platelet activation GO:0032844 regulation of homeostatic process GO:0032845 negative regulation of homeostatic process GO:0035637 multicellular organismal signaling GO:0042886 amide transport GO:0044057 regulation of system process GO:0044708 single-organism behavior GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0048016 inositol phosphate-mediated signaling GO:0048167 regulation of synaptic plasticity GO:0050708 regulation of protein secretion GO:0050796 regulation of insulin secretion GO:0050804 modulation of synaptic transmission GO:0050806 positive regulation of synaptic transmission GO:0050817 coagulation GO:0050878 regulation of body fluid levels GO:0050890 cognition GO:0050909 sensory perception of taste GO:0050913 sensory perception of bitter taste GO:0050916 sensory perception of sweet taste GO:0050917 sensory perception of umami taste GO:0051208 sequestering of calcium ion GO:0051209 release of sequestered calcium ion into cytosol GO:0051235 maintenance of location GO:0051238 sequestering of metal ion GO:0051259 protein oligomerization GO:0051260 protein homooligomerization GO:0051282 regulation of sequestering of calcium ion GO:0051283 negative regulation of sequestering of calcium ion GO:0051291 protein heterooligomerization GO:0051480 regulation of cytosolic calcium ion concentration GO:0051592 response to calcium ion GO:0055074 calcium ion homeostasis GO:0060047 heart contraction GO:0060291 long-term synaptic potentiation GO:0060401 cytosolic calcium ion transport GO:0060402 calcium ion transport into cytosol GO:0061337 cardiac conduction GO:0070509 calcium ion import GO:0070588 calcium ion transmembrane transport GO:0070838 divalent metal ion transport GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072511 divalent inorganic cation transport GO:0090087 regulation of peptide transport GO:0090276 regulation of peptide hormone secretion GO:0097553 calcium ion transmembrane import into cytosol GO:1902656 calcium ion import into cytosol GO:1903522 regulation of blood circulation GO:1903779 regulation of cardiac conduction GO:2000021 regulation of ion homeostasis |
Molecular Function |
GO:0000822 inositol hexakisphosphate binding GO:0005216 ion channel activity GO:0005217 intracellular ligand-gated ion channel activity GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity GO:0005261 cation channel activity GO:0005262 calcium channel activity GO:0005543 phospholipid binding GO:0015085 calcium ion transmembrane transporter activity GO:0015267 channel activity GO:0015276 ligand-gated ion channel activity GO:0015278 calcium-release channel activity GO:0022803 passive transmembrane transporter activity GO:0022834 ligand-gated channel activity GO:0022836 gated channel activity GO:0022838 substrate-specific channel activity GO:0035091 phosphatidylinositol binding GO:0043178 alcohol binding GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding GO:0046873 metal ion transmembrane transporter activity GO:0070679 inositol 1,4,5 trisphosphate binding GO:0072509 divalent inorganic cation transmembrane transporter activity GO:0099604 ligand-gated calcium channel activity |
Cellular Component |
GO:0005635 nuclear envelope GO:0005640 nuclear outer membrane GO:0005903 brush border GO:0016528 sarcoplasm GO:0016529 sarcoplasmic reticulum GO:0019867 outer membrane GO:0030141 secretory granule GO:0030659 cytoplasmic vesicle membrane GO:0030667 secretory granule membrane GO:0031094 platelet dense tubular network GO:0031095 platelet dense tubular network membrane GO:0031965 nuclear membrane GO:0031968 organelle outer membrane GO:0043025 neuronal cell body GO:0043209 myelin sheath GO:0043235 receptor complex GO:0044297 cell body GO:0045177 apical part of cell GO:0098862 cluster of actin-based cell projections GO:0099503 secretory vesicle |
KEGG |
hsa04020 Calcium signaling pathway hsa04022 cGMP-PKG signaling pathway hsa04070 Phosphatidylinositol signaling system hsa04114 Oocyte meiosis hsa04210 Apoptosis hsa04270 Vascular smooth muscle contraction hsa04540 Gap junction hsa04611 Platelet activation hsa04621 NOD-like receptor signaling pathway hsa04713 Circadian entrainment hsa04720 Long-term potentiation hsa04723 Retrograde endocannabinoid signaling hsa04724 Glutamatergic synapse hsa04725 Cholinergic synapse hsa04726 Serotonergic synapse hsa04728 Dopaminergic synapse hsa04730 Long-term depression hsa04742 Taste transduction hsa04750 Inflammatory mediator regulation of TRP channels hsa04911 Insulin secretion hsa04912 GnRH signaling pathway hsa04915 Estrogen signaling pathway hsa04918 Thyroid hormone synthesis hsa04921 Oxytocin signaling pathway hsa04922 Glucagon signaling pathway hsa04970 Salivary secretion hsa04971 Gastric acid secretion hsa04972 Pancreatic secretion |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-983695: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-3858494: Beta-catenin independent WNT signaling R-HSA-5621481: C-type lectin receptors (CLRs) R-HSA-5607763: CLEC7A (Dectin-1) induces NFAT activation R-HSA-5607764: CLEC7A (Dectin-1) signaling R-HSA-4086398: Ca2+ pathway R-HSA-5576891: Cardiac conduction R-HSA-1489509: DAG and IP3 signaling R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-186763: Downstream signal transduction R-HSA-212718: EGFR interacts with phospholipase C-gamma R-HSA-114508: Effects of PIP2 hydrolysis R-HSA-139853: Elevation of cytosolic Ca2+ levels R-HSA-2871809: FCERI mediated Ca+2 mobilization R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-2029480: Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-416476: G alpha (q) signalling events R-HSA-112040: G-protein mediated events R-HSA-388396: GPCR downstream signaling R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-381676: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-109582: Hemostasis R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-163685: Integration of energy metabolism R-HSA-5578775: Ion homeostasis R-HSA-1430728: Metabolism R-HSA-397014: Muscle contraction R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-111885: Opioid Signalling R-HSA-112043: PLC beta mediated events R-HSA-167021: PLC-gamma1 signalling R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-418360: Platelet calcium homeostasis R-HSA-418346: Platelet homeostasis R-HSA-422356: Regulation of insulin secretion R-HSA-2029485: Role of phospholipids in phagocytosis R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-372790: Signaling by GPCR R-HSA-186797: Signaling by PDGF R-HSA-194138: Signaling by VEGF R-HSA-195721: Signaling by Wnt R-HSA-983705: Signaling by the B Cell Receptor (BCR) R-HSA-166520: Signalling by NGF R-HSA-4420097: VEGFA-VEGFR2 Pathway R-HSA-5218921: VEGFR2 mediated cell proliferation |
Summary | |
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Symbol | ITPR3 |
Name | inositol 1,4,5-trisphosphate receptor, type 3 |
Aliases | IP3R3; inositol 1,4,5-triphosphate receptor, type 3; insP3R3; type 3 InsP3 receptor; Type 3 inositol 1,4,5-t ...... |
Chromosomal Location | 6p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ITPR3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ITPR3 |
Name | inositol 1,4,5-trisphosphate receptor, type 3 |
Aliases | IP3R3; inositol 1,4,5-triphosphate receptor, type 3; insP3R3; type 3 InsP3 receptor; Type 3 inositol 1,4,5-t ...... |
Chromosomal Location | 6p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ITPR3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ITPR3 |
Name | inositol 1,4,5-trisphosphate receptor, type 3 |
Aliases | IP3R3; inositol 1,4,5-triphosphate receptor, type 3; insP3R3; type 3 InsP3 receptor; Type 3 inositol 1,4,5-t ...... |
Chromosomal Location | 6p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ITPR3 in various data sets.
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Points in the above scatter plot represent the mutation difference of ITPR3 in various data sets.
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Summary | |
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Symbol | ITPR3 |
Name | inositol 1,4,5-trisphosphate receptor, type 3 |
Aliases | IP3R3; inositol 1,4,5-triphosphate receptor, type 3; insP3R3; type 3 InsP3 receptor; Type 3 inositol 1,4,5-t ...... |
Chromosomal Location | 6p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ITPR3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ITPR3 |
Name | inositol 1,4,5-trisphosphate receptor, type 3 |
Aliases | IP3R3; inositol 1,4,5-triphosphate receptor, type 3; insP3R3; type 3 InsP3 receptor; Type 3 inositol 1,4,5-t ...... |
Chromosomal Location | 6p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ITPR3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ITPR3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ITPR3 |
Name | inositol 1,4,5-trisphosphate receptor, type 3 |
Aliases | IP3R3; inositol 1,4,5-triphosphate receptor, type 3; insP3R3; type 3 InsP3 receptor; Type 3 inositol 1,4,5-t ...... |
Chromosomal Location | 6p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ITPR3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ITPR3 |
Name | inositol 1,4,5-trisphosphate receptor, type 3 |
Aliases | IP3R3; inositol 1,4,5-triphosphate receptor, type 3; insP3R3; type 3 InsP3 receptor; Type 3 inositol 1,4,5-t ...... |
Chromosomal Location | 6p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ITPR3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ITPR3 |
Name | inositol 1,4,5-trisphosphate receptor, type 3 |
Aliases | IP3R3; inositol 1,4,5-triphosphate receptor, type 3; insP3R3; type 3 InsP3 receptor; Type 3 inositol 1,4,5-t ...... |
Chromosomal Location | 6p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ITPR3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ITPR3 |
Name | inositol 1,4,5-trisphosphate receptor, type 3 |
Aliases | IP3R3; inositol 1,4,5-triphosphate receptor, type 3; insP3R3; type 3 InsP3 receptor; Type 3 inositol 1,4,5-t ...... |
Chromosomal Location | 6p21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ITPR3 collected from DrugBank database. |
Details on drugs targeting ITPR3.
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