Summary | |
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Symbol | JADE3 |
Name | jade family PHD finger 3 |
Aliases | KIAA0215; JADE-3; PHF16; PHD finger protein 16; jade family PHD finger protein 3; Protein Jade-3 |
Chromosomal Location | Xp11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF10513 Enhancer of polycomb-like |
Function |
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. |
Biological Process |
GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0016570 histone modification GO:0016573 histone acetylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0043543 protein acylation GO:0043966 histone H3 acetylation GO:0043967 histone H4 acetylation GO:0043981 histone H4-K5 acetylation GO:0043982 histone H4-K8 acetylation GO:0043983 histone H4-K12 acetylation |
Molecular Function | - |
Cellular Component |
GO:0000123 histone acetyltransferase complex GO:0031248 protein acetyltransferase complex GO:1902493 acetyltransferase complex |
KEGG | - |
Reactome |
R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214847: HATs acetylate histones |
Summary | |
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Symbol | JADE3 |
Name | jade family PHD finger 3 |
Aliases | KIAA0215; JADE-3; PHF16; PHD finger protein 16; jade family PHD finger protein 3; Protein Jade-3 |
Chromosomal Location | Xp11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between JADE3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | JADE3 |
Name | jade family PHD finger 3 |
Aliases | KIAA0215; JADE-3; PHF16; PHD finger protein 16; jade family PHD finger protein 3; Protein Jade-3 |
Chromosomal Location | Xp11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of JADE3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | JADE3 |
Name | jade family PHD finger 3 |
Aliases | KIAA0215; JADE-3; PHF16; PHD finger protein 16; jade family PHD finger protein 3; Protein Jade-3 |
Chromosomal Location | Xp11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of JADE3 in various data sets.
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Points in the above scatter plot represent the mutation difference of JADE3 in various data sets.
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Summary | |
---|---|
Symbol | JADE3 |
Name | jade family PHD finger 3 |
Aliases | KIAA0215; JADE-3; PHF16; PHD finger protein 16; jade family PHD finger protein 3; Protein Jade-3 |
Chromosomal Location | Xp11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of JADE3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | JADE3 |
Name | jade family PHD finger 3 |
Aliases | KIAA0215; JADE-3; PHF16; PHD finger protein 16; jade family PHD finger protein 3; Protein Jade-3 |
Chromosomal Location | Xp11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of JADE3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by JADE3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | JADE3 |
Name | jade family PHD finger 3 |
Aliases | KIAA0215; JADE-3; PHF16; PHD finger protein 16; jade family PHD finger protein 3; Protein Jade-3 |
Chromosomal Location | Xp11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of JADE3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | JADE3 |
Name | jade family PHD finger 3 |
Aliases | KIAA0215; JADE-3; PHF16; PHD finger protein 16; jade family PHD finger protein 3; Protein Jade-3 |
Chromosomal Location | Xp11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of JADE3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | JADE3 |
Name | jade family PHD finger 3 |
Aliases | KIAA0215; JADE-3; PHF16; PHD finger protein 16; jade family PHD finger protein 3; Protein Jade-3 |
Chromosomal Location | Xp11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between JADE3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | JADE3 |
Name | jade family PHD finger 3 |
Aliases | KIAA0215; JADE-3; PHF16; PHD finger protein 16; jade family PHD finger protein 3; Protein Jade-3 |
Chromosomal Location | Xp11.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting JADE3 collected from DrugBank database. |
There is no record. |