Summary | |
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Symbol | JAK2 |
Name | Janus kinase 2 |
Aliases | JTK10; THCYT3; JAK-2; Janus kinase 2 (a protein tyrosine kinase); Tyrosine-protein kinase JAK2 |
Chromosomal Location | 9p24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endomembrane system Peripheral membrane protein Cytoplasm Nucleus |
Domain |
PF07714 Protein tyrosine kinase PF00017 SH2 domain |
Function |
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:7615558). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:9618263). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B) (PubMed:21368206). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation (PubMed:20098430). Plays a role in cell cycle by phosphorylating CDKN1B (PubMed:21423214). Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin (PubMed:19783980). |
Biological Process |
GO:0000060 protein import into nucleus, translocation GO:0000186 activation of MAPKK activity GO:0001819 positive regulation of cytokine production GO:0001959 regulation of cytokine-mediated signaling pathway GO:0002237 response to molecule of bacterial origin GO:0002250 adaptive immune response GO:0002262 myeloid cell homeostasis GO:0002790 peptide secretion GO:0002791 regulation of peptide secretion GO:0002793 positive regulation of peptide secretion GO:0003013 circulatory system process GO:0003015 heart process GO:0006470 protein dephosphorylation GO:0006606 protein import into nucleus GO:0006809 nitric oxide biosynthetic process GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0006913 nucleocytoplasmic transport GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006979 response to oxidative stress GO:0007015 actin filament organization GO:0007162 negative regulation of cell adhesion GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007259 JAK-STAT cascade GO:0007260 tyrosine phosphorylation of STAT protein GO:0007262 STAT protein import into nucleus GO:0007498 mesoderm development GO:0007596 blood coagulation GO:0007599 hemostasis GO:0008015 blood circulation GO:0008016 regulation of heart contraction GO:0008154 actin polymerization or depolymerization GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress GO:0009306 protein secretion GO:0009755 hormone-mediated signaling pathway GO:0009914 hormone transport GO:0010656 negative regulation of muscle cell apoptotic process GO:0010657 muscle cell apoptotic process GO:0010658 striated muscle cell apoptotic process GO:0010659 cardiac muscle cell apoptotic process GO:0010660 regulation of muscle cell apoptotic process GO:0010662 regulation of striated muscle cell apoptotic process GO:0010664 negative regulation of striated muscle cell apoptotic process GO:0010665 regulation of cardiac muscle cell apoptotic process GO:0010667 negative regulation of cardiac muscle cell apoptotic process GO:0010810 regulation of cell-substrate adhesion GO:0010811 positive regulation of cell-substrate adhesion GO:0010817 regulation of hormone levels GO:0010921 regulation of phosphatase activity GO:0010922 positive regulation of phosphatase activity GO:0010950 positive regulation of endopeptidase activity GO:0010952 positive regulation of peptidase activity GO:0014065 phosphatidylinositol 3-kinase signaling GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO:0015833 peptide transport GO:0016311 dephosphorylation GO:0016570 histone modification GO:0016572 histone phosphorylation GO:0017038 protein import GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0022407 regulation of cell-cell adhesion GO:0022408 negative regulation of cell-cell adhesion GO:0023061 signal release GO:0030041 actin filament polymerization GO:0030072 peptide hormone secretion GO:0030073 insulin secretion GO:0030099 myeloid cell differentiation GO:0030218 erythrocyte differentiation GO:0030335 positive regulation of cell migration GO:0030518 intracellular steroid hormone receptor signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0030879 mammary gland development GO:0031099 regeneration GO:0031102 neuron projection regeneration GO:0031103 axon regeneration GO:0031349 positive regulation of defense response GO:0031589 cell-substrate adhesion GO:0031958 corticosteroid receptor signaling pathway GO:0031959 mineralocorticoid receptor signaling pathway GO:0032024 positive regulation of insulin secretion GO:0032103 positive regulation of response to external stimulus GO:0032147 activation of protein kinase activity GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032496 response to lipopolysaccharide GO:0032516 positive regulation of phosphoprotein phosphatase activity GO:0032611 interleukin-1 beta production GO:0032612 interleukin-1 production GO:0032640 tumor necrosis factor production GO:0032651 regulation of interleukin-1 beta production GO:0032652 regulation of interleukin-1 production GO:0032680 regulation of tumor necrosis factor production GO:0032731 positive regulation of interleukin-1 beta production GO:0032732 positive regulation of interleukin-1 production GO:0032760 positive regulation of tumor necrosis factor production GO:0033002 muscle cell proliferation GO:0033157 regulation of intracellular protein transport GO:0033158 regulation of protein import into nucleus, translocation GO:0033160 positive regulation of protein import into nucleus, translocation GO:0033194 response to hydroperoxide GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0033674 positive regulation of kinase activity GO:0034101 erythrocyte homeostasis GO:0034341 response to interferon-gamma GO:0034504 protein localization to nucleus GO:0034599 cellular response to oxidative stress GO:0034612 response to tumor necrosis factor GO:0035303 regulation of dephosphorylation GO:0035304 regulation of protein dephosphorylation GO:0035306 positive regulation of dephosphorylation GO:0035307 positive regulation of protein dephosphorylation GO:0035406 histone-tyrosine phosphorylation GO:0035409 histone H3-Y41 phosphorylation GO:0035722 interleukin-12-mediated signaling pathway GO:0036473 cell death in response to oxidative stress GO:0038083 peptidyl-tyrosine autophosphorylation GO:0040017 positive regulation of locomotion GO:0042306 regulation of protein import into nucleus GO:0042307 positive regulation of protein import into nucleus GO:0042503 tyrosine phosphorylation of Stat3 protein GO:0042506 tyrosine phosphorylation of Stat5 protein GO:0042508 tyrosine phosphorylation of Stat1 protein GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO:0042516 regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042522 regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0042886 amide transport GO:0042976 activation of Janus kinase activity GO:0042977 activation of JAK2 kinase activity GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043388 positive regulation of DNA binding GO:0043392 negative regulation of DNA binding GO:0043401 steroid hormone mediated signaling pathway GO:0043405 regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043434 response to peptide hormone GO:0043523 regulation of neuron apoptotic process GO:0043524 negative regulation of neuron apoptotic process GO:0043666 regulation of phosphoprotein phosphatase activity GO:0044057 regulation of system process GO:0044744 protein targeting to nucleus GO:0045088 regulation of innate immune response GO:0045428 regulation of nitric oxide biosynthetic process GO:0045429 positive regulation of nitric oxide biosynthetic process GO:0045785 positive regulation of cell adhesion GO:0045822 negative regulation of heart contraction GO:0045860 positive regulation of protein kinase activity GO:0045862 positive regulation of proteolysis GO:0046209 nitric oxide metabolic process GO:0046425 regulation of JAK-STAT cascade GO:0046427 positive regulation of JAK-STAT cascade GO:0046677 response to antibiotic GO:0046777 protein autophosphorylation GO:0046822 regulation of nucleocytoplasmic transport GO:0046824 positive regulation of nucleocytoplasmic transport GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0046887 positive regulation of hormone secretion GO:0048008 platelet-derived growth factor receptor signaling pathway GO:0048015 phosphatidylinositol-mediated signaling GO:0048017 inositol lipid-mediated signaling GO:0048545 response to steroid hormone GO:0048659 smooth muscle cell proliferation GO:0048660 regulation of smooth muscle cell proliferation GO:0048661 positive regulation of smooth muscle cell proliferation GO:0048678 response to axon injury GO:0048732 gland development GO:0048872 homeostasis of number of cells GO:0050708 regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0050727 regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050796 regulation of insulin secretion GO:0050817 coagulation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050878 regulation of body fluid levels GO:0051047 positive regulation of secretion GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051098 regulation of binding GO:0051099 positive regulation of binding GO:0051100 negative regulation of binding GO:0051101 regulation of DNA binding GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051222 positive regulation of protein transport GO:0051258 protein polymerization GO:0051272 positive regulation of cellular component movement GO:0051402 neuron apoptotic process GO:0051480 regulation of cytosolic calcium ion concentration GO:0051767 nitric-oxide synthase biosynthetic process GO:0051769 regulation of nitric-oxide synthase biosynthetic process GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0055074 calcium ion homeostasis GO:0060047 heart contraction GO:0060330 regulation of response to interferon-gamma GO:0060333 interferon-gamma-mediated signaling pathway GO:0060334 regulation of interferon-gamma-mediated signaling pathway GO:0060396 growth hormone receptor signaling pathway GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060398 regulation of growth hormone receptor signaling pathway GO:0060399 positive regulation of growth hormone receptor signaling pathway GO:0060416 response to growth hormone GO:0060759 regulation of response to cytokine stimulus GO:0061180 mammary gland epithelium development GO:0061564 axon development GO:0070671 response to interleukin-12 GO:0070997 neuron death GO:0071346 cellular response to interferon-gamma GO:0071349 cellular response to interleukin-12 GO:0071356 cellular response to tumor necrosis factor GO:0071375 cellular response to peptide hormone stimulus GO:0071378 cellular response to growth hormone stimulus GO:0071383 cellular response to steroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071706 tumor necrosis factor superfamily cytokine production GO:0071900 regulation of protein serine/threonine kinase activity GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072593 reactive oxygen species metabolic process GO:0090087 regulation of peptide transport GO:0090276 regulation of peptide hormone secretion GO:0090277 positive regulation of peptide hormone secretion GO:0090316 positive regulation of intracellular protein transport GO:0097191 extrinsic apoptotic signaling pathway GO:0097193 intrinsic apoptotic signaling pathway GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097696 STAT cascade GO:1900180 regulation of protein localization to nucleus GO:1900182 positive regulation of protein localization to nucleus GO:1901214 regulation of neuron death GO:1901215 negative regulation of neuron death GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1902593 single-organism nuclear import GO:1902728 positive regulation of growth factor dependent skeletal muscle satellite cell proliferation GO:1903409 reactive oxygen species biosynthetic process GO:1903426 regulation of reactive oxygen species biosynthetic process GO:1903428 positive regulation of reactive oxygen species biosynthetic process GO:1903522 regulation of blood circulation GO:1903523 negative regulation of blood circulation GO:1903532 positive regulation of secretion by cell GO:1903533 regulation of protein targeting GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production GO:1903829 positive regulation of cellular protein localization GO:1904019 epithelial cell apoptotic process GO:1904035 regulation of epithelial cell apoptotic process GO:1904037 positive regulation of epithelial cell apoptotic process GO:1904407 positive regulation of nitric oxide metabolic process GO:1904589 regulation of protein import GO:1904591 positive regulation of protein import GO:1904705 regulation of vascular smooth muscle cell proliferation GO:1904707 positive regulation of vascular smooth muscle cell proliferation GO:1904892 regulation of STAT cascade GO:1904894 positive regulation of STAT cascade GO:1904951 positive regulation of establishment of protein localization GO:1990874 vascular smooth muscle cell proliferation GO:2000116 regulation of cysteine-type endopeptidase activity GO:2000147 positive regulation of cell motility GO:2000377 regulation of reactive oxygen species metabolic process GO:2000379 positive regulation of reactive oxygen species metabolic process GO:2001056 positive regulation of cysteine-type endopeptidase activity GO:2001057 reactive nitrogen species metabolic process GO:2001233 regulation of apoptotic signaling pathway GO:2001235 positive regulation of apoptotic signaling pathway GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
Molecular Function |
GO:0001664 G-protein coupled receptor binding GO:0004713 protein tyrosine kinase activity GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0005085 guanyl-nucleotide exchange factor activity GO:0005088 Ras guanyl-nucleotide exchange factor activity GO:0005126 cytokine receptor binding GO:0005131 growth hormone receptor binding GO:0005143 interleukin-12 receptor binding GO:0008022 protein C-terminus binding GO:0020037 heme binding GO:0031701 angiotensin receptor binding GO:0031702 type 1 angiotensin receptor binding GO:0033130 acetylcholine receptor binding GO:0035173 histone kinase activity GO:0035400 histone tyrosine kinase activity GO:0035401 histone kinase activity (H3-Y41 specific) GO:0042169 SH2 domain binding GO:0042393 histone binding GO:0043548 phosphatidylinositol 3-kinase binding GO:0043560 insulin receptor substrate binding GO:0046906 tetrapyrrole binding GO:0051427 hormone receptor binding GO:0051428 peptide hormone receptor binding GO:0070851 growth factor receptor binding |
Cellular Component |
GO:0005775 vacuolar lumen GO:0005901 caveola GO:0009898 cytoplasmic side of plasma membrane GO:0016363 nuclear matrix GO:0019897 extrinsic component of plasma membrane GO:0019898 extrinsic component of membrane GO:0031234 extrinsic component of cytoplasmic side of plasma membrane GO:0031904 endosome lumen GO:0034399 nuclear periphery GO:0044440 endosomal part GO:0044853 plasma membrane raft GO:0045121 membrane raft GO:0098552 side of membrane GO:0098562 cytoplasmic side of membrane GO:0098589 membrane region GO:0098857 membrane microdomain |
KEGG |
hsa04062 Chemokine signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04550 Signaling pathways regulating pluripotency of stem cells hsa04630 Jak-STAT signaling pathway hsa04725 Cholinergic synapse hsa04917 Prolactin signaling pathway hsa04920 Adipocytokine signaling pathway |
Reactome |
R-HSA-170984: ARMS-mediated activation R-HSA-422475: Axon guidance R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-186763: Downstream signal transduction R-HSA-2871796: FCERI mediated MAPK activation R-HSA-983231: Factors involved in megakaryocyte development and platelet production R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-170968: Frs2-mediated activation R-HSA-392451: G beta R-HSA-397795: G-protein beta R-HSA-388396: GPCR downstream signaling R-HSA-114604: GPVI-mediated activation cascade R-HSA-179812: GRB2 events in EGFR signaling R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-982772: Growth hormone receptor signaling R-HSA-109582: Hemostasis R-HSA-2428924: IGF1R signaling cascade R-HSA-6788467: IL-6-type cytokine receptor ligand interactions R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-74751: Insulin receptor signalling cascade R-HSA-913531: Interferon Signaling R-HSA-877300: Interferon gamma signaling R-HSA-912526: Interleukin receptor SHC signaling R-HSA-451927: Interleukin-2 signaling R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-6783589: Interleukin-6 family signaling R-HSA-1059683: Interleukin-6 signaling R-HSA-5683057: MAPK family signaling cascades R-HSA-112411: MAPK1 (ERK2) activation R-HSA-5684996: MAPK1/MAPK3 signaling R-HSA-110056: MAPK3 (ERK1) activation R-HSA-375165: NCAM signaling for neurite out-growth R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-6802957: Oncogenic MAPK signaling R-HSA-6802955: Paradoxical activation of RAF signaling by kinase inactive BRAF R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-1170546: Prolactin receptor signaling R-HSA-169893: Prolonged ERK activation events R-HSA-5673000: RAF activation R-HSA-112409: RAF-independent MAPK1/3 activation R-HSA-5673001: RAF/MAP kinase cascade R-HSA-8853659: RET signaling R-HSA-3214858: RMTs methylate histone arginines R-HSA-877312: Regulation of IFNG signaling R-HSA-180336: SHC1 events in EGFR signaling R-HSA-112412: SOS-mediated signalling R-HSA-162582: Signal Transduction R-HSA-6802952: Signaling by BRAF and RAF fusions R-HSA-177929: Signaling by EGFR R-HSA-372790: Signaling by GPCR R-HSA-74752: Signaling by Insulin receptor R-HSA-449147: Signaling by Interleukins R-HSA-2586552: Signaling by Leptin R-HSA-186797: Signaling by PDGF R-HSA-6802949: Signaling by RAS mutants R-HSA-1433557: Signaling by SCF-KIT R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-194138: Signaling by VEGF R-HSA-6802946: Signaling by moderate kinase activity BRAF mutants R-HSA-166520: Signalling by NGF R-HSA-187687: Signalling to ERKs R-HSA-167044: Signalling to RAS R-HSA-187706: Signalling to p38 via RIT and RIN R-HSA-4420097: VEGFA-VEGFR2 Pathway R-HSA-5218921: VEGFR2 mediated cell proliferation |
Summary | |
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Symbol | JAK2 |
Name | Janus kinase 2 |
Aliases | JTK10; THCYT3; JAK-2; Janus kinase 2 (a protein tyrosine kinase); Tyrosine-protein kinase JAK2 |
Chromosomal Location | 9p24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between JAK2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between JAK2 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | JAK2 |
Name | Janus kinase 2 |
Aliases | JTK10; THCYT3; JAK-2; Janus kinase 2 (a protein tyrosine kinase); Tyrosine-protein kinase JAK2 |
Chromosomal Location | 9p24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of JAK2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | JAK2 |
Name | Janus kinase 2 |
Aliases | JTK10; THCYT3; JAK-2; Janus kinase 2 (a protein tyrosine kinase); Tyrosine-protein kinase JAK2 |
Chromosomal Location | 9p24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of JAK2 in various data sets.
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Points in the above scatter plot represent the mutation difference of JAK2 in various data sets.
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Summary | |
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Symbol | JAK2 |
Name | Janus kinase 2 |
Aliases | JTK10; THCYT3; JAK-2; Janus kinase 2 (a protein tyrosine kinase); Tyrosine-protein kinase JAK2 |
Chromosomal Location | 9p24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of JAK2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | JAK2 |
Name | Janus kinase 2 |
Aliases | JTK10; THCYT3; JAK-2; Janus kinase 2 (a protein tyrosine kinase); Tyrosine-protein kinase JAK2 |
Chromosomal Location | 9p24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of JAK2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by JAK2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | JAK2 |
Name | Janus kinase 2 |
Aliases | JTK10; THCYT3; JAK-2; Janus kinase 2 (a protein tyrosine kinase); Tyrosine-protein kinase JAK2 |
Chromosomal Location | 9p24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of JAK2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | JAK2 |
Name | Janus kinase 2 |
Aliases | JTK10; THCYT3; JAK-2; Janus kinase 2 (a protein tyrosine kinase); Tyrosine-protein kinase JAK2 |
Chromosomal Location | 9p24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of JAK2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | JAK2 |
Name | Janus kinase 2 |
Aliases | JTK10; THCYT3; JAK-2; Janus kinase 2 (a protein tyrosine kinase); Tyrosine-protein kinase JAK2 |
Chromosomal Location | 9p24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between JAK2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | JAK2 |
Name | Janus kinase 2 |
Aliases | JTK10; THCYT3; JAK-2; Janus kinase 2 (a protein tyrosine kinase); Tyrosine-protein kinase JAK2 |
Chromosomal Location | 9p24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting JAK2 collected from DrugBank database. |
Details on drugs targeting JAK2.
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