Summary | |
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Symbol | JUN |
Name | jun proto-oncogene |
Aliases | c-Jun; v-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog (avian); jun o ...... |
Chromosomal Location | 1p32-p31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus. |
Domain |
PF00170 bZIP transcription factor PF03957 Jun-like transcription factor |
Function |
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306). |
Biological Process |
GO:0000302 response to reactive oxygen species GO:0001525 angiogenesis GO:0001654 eye development GO:0001667 ameboidal-type cell migration GO:0001774 microglial cell activation GO:0001836 release of cytochrome c from mitochondria GO:0001889 liver development GO:0001933 negative regulation of protein phosphorylation GO:0001935 endothelial cell proliferation GO:0001936 regulation of endothelial cell proliferation GO:0001938 positive regulation of endothelial cell proliferation GO:0002237 response to molecule of bacterial origin GO:0002274 myeloid leukocyte activation GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0002761 regulation of myeloid leukocyte differentiation GO:0002763 positive regulation of myeloid leukocyte differentiation GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0003007 heart morphogenesis GO:0003151 outflow tract morphogenesis GO:0006260 DNA replication GO:0006275 regulation of DNA replication GO:0006352 DNA-templated transcription, initiation GO:0006606 protein import into nucleus GO:0006913 nucleocytoplasmic transport GO:0006979 response to oxidative stress GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007179 transforming growth factor beta receptor signaling pathway GO:0007184 SMAD protein import into nucleus GO:0007265 Ras protein signal transduction GO:0007423 sensory organ development GO:0007507 heart development GO:0007568 aging GO:0007611 learning or memory GO:0007612 learning GO:0007623 circadian rhythm GO:0008637 apoptotic mitochondrial changes GO:0009267 cellular response to starvation GO:0009314 response to radiation GO:0009612 response to mechanical stimulus GO:0009991 response to extracellular stimulus GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010634 positive regulation of epithelial cell migration GO:0014074 response to purine-containing compound GO:0017038 protein import GO:0019058 viral life cycle GO:0019080 viral gene expression GO:0019083 viral transcription GO:0030099 myeloid cell differentiation GO:0030224 monocyte differentiation GO:0030335 positive regulation of cell migration GO:0031099 regeneration GO:0031102 neuron projection regeneration GO:0031103 axon regeneration GO:0031334 positive regulation of protein complex assembly GO:0031667 response to nutrient levels GO:0031668 cellular response to extracellular stimulus GO:0031669 cellular response to nutrient levels GO:0031952 regulation of protein autophosphorylation GO:0031953 negative regulation of protein autophosphorylation GO:0032496 response to lipopolysaccharide GO:0032897 negative regulation of viral transcription GO:0033002 muscle cell proliferation GO:0034504 protein localization to nucleus GO:0034976 response to endoplasmic reticulum stress GO:0035026 leading edge cell differentiation GO:0035821 modification of morphology or physiology of other organism GO:0035994 response to muscle stretch GO:0038093 Fc receptor signaling pathway GO:0038095 Fc-epsilon receptor signaling pathway GO:0040017 positive regulation of locomotion GO:0042116 macrophage activation GO:0042326 negative regulation of phosphorylation GO:0042391 regulation of membrane potential GO:0042493 response to drug GO:0042542 response to hydrogen peroxide GO:0042594 response to starvation GO:0043010 camera-type eye development GO:0043254 regulation of protein complex assembly GO:0043392 negative regulation of DNA binding GO:0043410 positive regulation of MAPK cascade GO:0043523 regulation of neuron apoptotic process GO:0043524 negative regulation of neuron apoptotic process GO:0043525 positive regulation of neuron apoptotic process GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress GO:0043620 regulation of DNA-templated transcription in response to stress GO:0043900 regulation of multi-organism process GO:0043901 negative regulation of multi-organism process GO:0043902 positive regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0043921 modulation by host of viral transcription GO:0043922 negative regulation by host of viral transcription GO:0043923 positive regulation by host of viral transcription GO:0044033 multi-organism metabolic process GO:0044089 positive regulation of cellular component biogenesis GO:0044708 single-organism behavior GO:0044744 protein targeting to nucleus GO:0045637 regulation of myeloid cell differentiation GO:0045639 positive regulation of myeloid cell differentiation GO:0045655 regulation of monocyte differentiation GO:0045657 positive regulation of monocyte differentiation GO:0045740 positive regulation of DNA replication GO:0046683 response to organophosphorus GO:0046777 protein autophosphorylation GO:0046782 regulation of viral transcription GO:0048144 fibroblast proliferation GO:0048145 regulation of fibroblast proliferation GO:0048146 positive regulation of fibroblast proliferation GO:0048511 rhythmic process GO:0048514 blood vessel morphogenesis GO:0048524 positive regulation of viral process GO:0048525 negative regulation of viral process GO:0048659 smooth muscle cell proliferation GO:0048660 regulation of smooth muscle cell proliferation GO:0048661 positive regulation of smooth muscle cell proliferation GO:0048678 response to axon injury GO:0048732 gland development GO:0050434 positive regulation of viral transcription GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0050792 regulation of viral process GO:0050890 cognition GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051098 regulation of binding GO:0051100 negative regulation of binding GO:0051101 regulation of DNA binding GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051272 positive regulation of cellular component movement GO:0051365 cellular response to potassium ion starvation GO:0051402 neuron apoptotic process GO:0051591 response to cAMP GO:0051592 response to calcium ion GO:0051702 interaction with symbiont GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051851 modification by host of symbiont morphology or physiology GO:0051899 membrane depolarization GO:0052312 modulation of transcription in other organism involved in symbiotic interaction GO:0052472 modulation by host of symbiont transcription GO:0060395 SMAD protein signal transduction GO:0061008 hepaticobiliary system development GO:0061029 eyelid development in camera-type eye GO:0061564 axon development GO:0061614 pri-miRNA transcription from RNA polymerase II promoter GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0070997 neuron death GO:0071241 cellular response to inorganic substance GO:0071248 cellular response to metal ion GO:0071277 cellular response to calcium ion GO:0071496 cellular response to external stimulus GO:0071559 response to transforming growth factor beta GO:0071560 cellular response to transforming growth factor beta stimulus GO:0090130 tissue migration GO:0090132 epithelium migration GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress GO:1901214 regulation of neuron death GO:1901215 negative regulation of neuron death GO:1901216 positive regulation of neuron death GO:1902105 regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1902593 single-organism nuclear import GO:1902893 regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1903131 mononuclear cell differentiation GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:1903900 regulation of viral life cycle GO:1903901 negative regulation of viral life cycle GO:1903902 positive regulation of viral life cycle GO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress GO:2000142 regulation of DNA-templated transcription, initiation GO:2000144 positive regulation of DNA-templated transcription, initiation GO:2000147 positive regulation of cell motility |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001085 RNA polymerase II transcription factor binding GO:0001102 RNA polymerase II activating transcription factor binding GO:0001158 enhancer sequence-specific DNA binding GO:0001159 core promoter proximal region DNA binding GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003682 chromatin binding GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003713 transcription coactivator activity GO:0005096 GTPase activator activity GO:0008047 enzyme activator activity GO:0008134 transcription factor binding GO:0030695 GTPase regulator activity GO:0033613 activating transcription factor binding GO:0035326 enhancer binding GO:0035497 cAMP response element binding GO:0046332 SMAD binding GO:0046982 protein heterodimerization activity GO:0060589 nucleoside-triphosphatase regulator activity GO:0070412 R-SMAD binding GO:0071837 HMG box domain binding GO:0098811 transcriptional repressor activity, RNA polymerase II activating transcription factor binding |
Cellular Component |
GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0000791 euchromatin GO:0005667 transcription factor complex GO:0005719 nuclear euchromatin GO:0017053 transcriptional repressor complex GO:0044454 nuclear chromosome part |
KEGG |
hsa04010 MAPK signaling pathway hsa04012 ErbB signaling pathway hsa04024 cAMP signaling pathway hsa04210 Apoptosis hsa04310 Wnt signaling pathway hsa04380 Osteoclast differentiation hsa04510 Focal adhesion hsa04530 Tight junction hsa04620 Toll-like receptor signaling pathway hsa04621 NOD-like receptor signaling pathway hsa04660 T cell receptor signaling pathway hsa04662 B cell receptor signaling pathway hsa04668 TNF signaling pathway hsa04722 Neurotrophin signaling pathway hsa04912 GnRH signaling pathway hsa04915 Estrogen signaling pathway hsa04921 Oxytocin signaling pathway |
Reactome |
R-HSA-166054: Activated TLR4 signalling R-HSA-5619507: Activation of HOX genes during differentiation R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-450341: Activation of the AP-1 family of transcription factors R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-8862803: Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-2871796: FCERI mediated MAPK activation R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-450294: MAP kinase activation in TLR cascade R-HSA-5683057: MAPK family signaling cascades R-HSA-450282: MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-5687128: MAPK6/MAPK4 signaling R-HSA-975871: MyD88 cascade initiated on plasma membrane R-HSA-975155: MyD88 dependent cascade initiated on endosome R-HSA-166166: MyD88-independent TLR3/TLR4 cascade R-HSA-166058: MyD88 R-HSA-8863678: Neurodegenerative Diseases R-HSA-2559580: Oxidative Stress Induced Senescence R-HSA-1912422: Pre-NOTCH Expression and Processing R-HSA-1912408: Pre-NOTCH Transcription and Translation R-HSA-2559582: Senescence-Associated Secretory Phenotype (SASP) R-HSA-162582: Signal Transduction R-HSA-157118: Signaling by NOTCH R-HSA-6796648: TP53 Regulates Transcription of DNA Repair Genes R-HSA-168180: TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-975138: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-937061: TRIF-mediated TLR3/TLR4 signaling R-HSA-168142: Toll Like Receptor 10 (TLR10) Cascade R-HSA-181438: Toll Like Receptor 2 (TLR2) Cascade R-HSA-168164: Toll Like Receptor 3 (TLR3) Cascade R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade R-HSA-168176: Toll Like Receptor 5 (TLR5) Cascade R-HSA-168181: Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168138: Toll Like Receptor 9 (TLR9) Cascade R-HSA-168179: Toll Like Receptor TLR1 R-HSA-168188: Toll Like Receptor TLR6 R-HSA-168898: Toll-Like Receptors Cascades R-HSA-3700989: Transcriptional Regulation by TP53 |
Summary | |
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Symbol | JUN |
Name | jun proto-oncogene |
Aliases | c-Jun; v-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog (avian); jun o ...... |
Chromosomal Location | 1p32-p31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between JUN and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between JUN and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | JUN |
Name | jun proto-oncogene |
Aliases | c-Jun; v-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog (avian); jun o ...... |
Chromosomal Location | 1p32-p31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of JUN in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | JUN |
Name | jun proto-oncogene |
Aliases | c-Jun; v-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog (avian); jun o ...... |
Chromosomal Location | 1p32-p31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of JUN in various data sets.
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Points in the above scatter plot represent the mutation difference of JUN in various data sets.
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Summary | |
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Symbol | JUN |
Name | jun proto-oncogene |
Aliases | c-Jun; v-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog (avian); jun o ...... |
Chromosomal Location | 1p32-p31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of JUN. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | JUN |
Name | jun proto-oncogene |
Aliases | c-Jun; v-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog (avian); jun o ...... |
Chromosomal Location | 1p32-p31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of JUN. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by JUN. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | JUN |
Name | jun proto-oncogene |
Aliases | c-Jun; v-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog (avian); jun o ...... |
Chromosomal Location | 1p32-p31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of JUN. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | JUN |
Name | jun proto-oncogene |
Aliases | c-Jun; v-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog (avian); jun o ...... |
Chromosomal Location | 1p32-p31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of JUN expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | JUN |
Name | jun proto-oncogene |
Aliases | c-Jun; v-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog (avian); jun o ...... |
Chromosomal Location | 1p32-p31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between JUN and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | JUN |
Name | jun proto-oncogene |
Aliases | c-Jun; v-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog (avian); jun o ...... |
Chromosomal Location | 1p32-p31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting JUN collected from DrugBank database. |
Details on drugs targeting JUN.
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