Browse KALRN

Summary
SymbolKALRN
Namekalirin, RhoGEF kinase
Aliases duo; Hs.8004; DUET; Kalirin; ARHGEF24; serine/threonine kinase with Dbl and pleckstrin homology domains; hun ......
Chromosomal Location3q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Cytoplasm, cytoskeleton Note=Associated with the cytoskeleton.
Domain PF00650 CRAL/TRIO domain
PF00041 Fibronectin type III domain
PF07679 Immunoglobulin I-set domain
PF00169 PH domain
PF00069 Protein kinase domain
PF00621 RhoGEF domain
PF00435 Spectrin repeat
Function

Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.

> Gene Ontology
 
Biological Process GO:0001662 behavioral fear response
GO:0002209 behavioral defense response
GO:0007009 plasma membrane organization
GO:0007265 Ras protein signal transduction
GO:0007266 Rho protein signal transduction
GO:0007270 neuron-neuron synaptic transmission
GO:0007611 learning or memory
GO:0007613 memory
GO:0010720 positive regulation of cell development
GO:0010769 regulation of cell morphogenesis involved in differentiation
GO:0010770 positive regulation of cell morphogenesis involved in differentiation
GO:0010975 regulation of neuron projection development
GO:0010976 positive regulation of neuron projection development
GO:0016358 dendrite development
GO:0022604 regulation of cell morphogenesis
GO:0030534 adult behavior
GO:0031346 positive regulation of cell projection organization
GO:0033555 multicellular organismal response to stress
GO:0035023 regulation of Rho protein signal transduction
GO:0035176 social behavior
GO:0035249 synaptic transmission, glutamatergic
GO:0042220 response to cocaine
GO:0042596 fear response
GO:0043279 response to alkaloid
GO:0044708 single-organism behavior
GO:0045666 positive regulation of neuron differentiation
GO:0046578 regulation of Ras protein signal transduction
GO:0048013 ephrin receptor signaling pathway
GO:0048148 behavioral response to cocaine
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048813 dendrite morphogenesis
GO:0048814 regulation of dendrite morphogenesis
GO:0050769 positive regulation of neurogenesis
GO:0050773 regulation of dendrite development
GO:0050775 positive regulation of dendrite morphogenesis
GO:0050804 modulation of synaptic transmission
GO:0050890 cognition
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051703 intraspecies interaction between organisms
GO:0051705 multi-organism behavior
GO:0051962 positive regulation of nervous system development
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0060996 dendritic spine development
GO:0060997 dendritic spine morphogenesis
GO:0060998 regulation of dendritic spine development
GO:0060999 positive regulation of dendritic spine development
GO:0061001 regulation of dendritic spine morphogenesis
GO:0061003 positive regulation of dendritic spine morphogenesis
GO:0072657 protein localization to membrane
GO:0072659 protein localization to plasma membrane
GO:0097061 dendritic spine organization
GO:1900006 positive regulation of dendrite development
GO:1903076 regulation of protein localization to plasma membrane
GO:1903729 regulation of plasma membrane organization
GO:1904375 regulation of protein localization to cell periphery
GO:1990778 protein localization to cell periphery
Molecular Function GO:0004674 protein serine/threonine kinase activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0008047 enzyme activator activity
GO:0030695 GTPase regulator activity
GO:0060589 nucleoside-triphosphatase regulator activity
Cellular Component GO:0015629 actin cytoskeleton
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-422475: Axon guidance
R-HSA-204998: Cell death signalling via NRAGE, NRIF and NADE
R-HSA-1266738: Developmental Biology
R-HSA-2682334: EPH-Ephrin signaling
R-HSA-3928662: EPHB-mediated forward signaling
R-HSA-416482: G alpha (12/13) signalling events
R-HSA-416476: G alpha (q) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-5683057: MAPK family signaling cascades
R-HSA-5687128: MAPK6/MAPK4 signaling
R-HSA-193648: NRAGE signals death through JNK
R-HSA-194840: Rho GTPase cycle
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
R-HSA-194315: Signaling by Rho GTPases
R-HSA-166520: Signalling by NGF
R-HSA-193704: p75 NTR receptor-mediated signalling
Summary
SymbolKALRN
Namekalirin, RhoGEF kinase
Aliases duo; Hs.8004; DUET; Kalirin; ARHGEF24; serine/threonine kinase with Dbl and pleckstrin homology domains; hun ......
Chromosomal Location3q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between KALRN and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolKALRN
Namekalirin, RhoGEF kinase
Aliases duo; Hs.8004; DUET; Kalirin; ARHGEF24; serine/threonine kinase with Dbl and pleckstrin homology domains; hun ......
Chromosomal Location3q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of KALRN in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolKALRN
Namekalirin, RhoGEF kinase
Aliases duo; Hs.8004; DUET; Kalirin; ARHGEF24; serine/threonine kinase with Dbl and pleckstrin homology domains; hun ......
Chromosomal Location3q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of KALRN in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0480.896
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1360.848
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.1810.759
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2170.508
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.3170.886
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.0880.976
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3080.507
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.3710.756
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.3240.791
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.590.516
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.5080.216
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0040.979
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of KALRN in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141721.4021.40.081
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103300300.528
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277325.98.217.70.0389
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275925.98.517.40.0441
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211747.611.835.80.0336
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86500500.0849
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131146.218.2280.211
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91633.312.520.80.312
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59400400.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 472528.6-3.61
1329033130MelanomaallAnti-PD-1 (nivolumab) 382718.43.714.70.126
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221327.37.719.60.22
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolKALRN
Namekalirin, RhoGEF kinase
Aliases duo; Hs.8004; DUET; Kalirin; ARHGEF24; serine/threonine kinase with Dbl and pleckstrin homology domains; hun ......
Chromosomal Location3q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KALRN. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolKALRN
Namekalirin, RhoGEF kinase
Aliases duo; Hs.8004; DUET; Kalirin; ARHGEF24; serine/threonine kinase with Dbl and pleckstrin homology domains; hun ......
Chromosomal Location3q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KALRN. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KALRN.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolKALRN
Namekalirin, RhoGEF kinase
Aliases duo; Hs.8004; DUET; Kalirin; ARHGEF24; serine/threonine kinase with Dbl and pleckstrin homology domains; hun ......
Chromosomal Location3q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KALRN. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolKALRN
Namekalirin, RhoGEF kinase
Aliases duo; Hs.8004; DUET; Kalirin; ARHGEF24; serine/threonine kinase with Dbl and pleckstrin homology domains; hun ......
Chromosomal Location3q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of KALRN expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolKALRN
Namekalirin, RhoGEF kinase
Aliases duo; Hs.8004; DUET; Kalirin; ARHGEF24; serine/threonine kinase with Dbl and pleckstrin homology domains; hun ......
Chromosomal Location3q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between KALRN and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolKALRN
Namekalirin, RhoGEF kinase
Aliases duo; Hs.8004; DUET; Kalirin; ARHGEF24; serine/threonine kinase with Dbl and pleckstrin homology domains; hun ......
Chromosomal Location3q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting KALRN collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.