Summary | |
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Symbol | KANSL1 |
Name | KAT8 regulatory NSL complex subunit 1 |
Aliases | DKFZP727C091; MSL1v1; CENP-36; centromere protein 36; KIAA1267; KDVS; hMSL1v1; MLL1/MLL complex subunit KANS ...... |
Chromosomal Location | 17q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Nucleus. Chromosome, centromere, kinetochore |
Domain |
PF15275 PEHE domain |
Function |
As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. |
Biological Process |
GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0016570 histone modification GO:0016573 histone acetylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0043543 protein acylation GO:0043967 histone H4 acetylation GO:0043981 histone H4-K5 acetylation GO:0043982 histone H4-K8 acetylation GO:0043984 histone H4-K16 acetylation |
Molecular Function |
GO:0001047 core promoter binding GO:0004402 histone acetyltransferase activity GO:0008080 N-acetyltransferase activity GO:0010485 H4 histone acetyltransferase activity GO:0016407 acetyltransferase activity GO:0016410 N-acyltransferase activity GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0034212 peptide N-acetyltransferase activity GO:0035035 histone acetyltransferase binding GO:0043995 histone acetyltransferase activity (H4-K5 specific) GO:0043996 histone acetyltransferase activity (H4-K8 specific) GO:0046972 histone acetyltransferase activity (H4-K16 specific) GO:0061733 peptide-lysine-N-acetyltransferase activity |
Cellular Component |
GO:0000123 histone acetyltransferase complex GO:0000775 chromosome, centromeric region GO:0000776 kinetochore GO:0000777 condensed chromosome kinetochore GO:0000779 condensed chromosome, centromeric region GO:0000793 condensed chromosome GO:0031248 protein acetyltransferase complex GO:0034708 methyltransferase complex GO:0035097 histone methyltransferase complex GO:0044545 NSL complex GO:0044665 MLL1/2 complex GO:0071339 MLL1 complex GO:0098687 chromosomal region GO:1902493 acetyltransferase complex GO:1902562 H4 histone acetyltransferase complex |
KEGG | - |
Reactome |
R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214847: HATs acetylate histones |
Summary | |
---|---|
Symbol | KANSL1 |
Name | KAT8 regulatory NSL complex subunit 1 |
Aliases | DKFZP727C091; MSL1v1; CENP-36; centromere protein 36; KIAA1267; KDVS; hMSL1v1; MLL1/MLL complex subunit KANS ...... |
Chromosomal Location | 17q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between KANSL1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | KANSL1 |
Name | KAT8 regulatory NSL complex subunit 1 |
Aliases | DKFZP727C091; MSL1v1; CENP-36; centromere protein 36; KIAA1267; KDVS; hMSL1v1; MLL1/MLL complex subunit KANS ...... |
Chromosomal Location | 17q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of KANSL1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | KANSL1 |
Name | KAT8 regulatory NSL complex subunit 1 |
Aliases | DKFZP727C091; MSL1v1; CENP-36; centromere protein 36; KIAA1267; KDVS; hMSL1v1; MLL1/MLL complex subunit KANS ...... |
Chromosomal Location | 17q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of KANSL1 in various data sets.
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Points in the above scatter plot represent the mutation difference of KANSL1 in various data sets.
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Summary | |
---|---|
Symbol | KANSL1 |
Name | KAT8 regulatory NSL complex subunit 1 |
Aliases | DKFZP727C091; MSL1v1; CENP-36; centromere protein 36; KIAA1267; KDVS; hMSL1v1; MLL1/MLL complex subunit KANS ...... |
Chromosomal Location | 17q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KANSL1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | KANSL1 |
Name | KAT8 regulatory NSL complex subunit 1 |
Aliases | DKFZP727C091; MSL1v1; CENP-36; centromere protein 36; KIAA1267; KDVS; hMSL1v1; MLL1/MLL complex subunit KANS ...... |
Chromosomal Location | 17q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KANSL1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KANSL1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | KANSL1 |
Name | KAT8 regulatory NSL complex subunit 1 |
Aliases | DKFZP727C091; MSL1v1; CENP-36; centromere protein 36; KIAA1267; KDVS; hMSL1v1; MLL1/MLL complex subunit KANS ...... |
Chromosomal Location | 17q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KANSL1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | KANSL1 |
Name | KAT8 regulatory NSL complex subunit 1 |
Aliases | DKFZP727C091; MSL1v1; CENP-36; centromere protein 36; KIAA1267; KDVS; hMSL1v1; MLL1/MLL complex subunit KANS ...... |
Chromosomal Location | 17q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of KANSL1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | KANSL1 |
Name | KAT8 regulatory NSL complex subunit 1 |
Aliases | DKFZP727C091; MSL1v1; CENP-36; centromere protein 36; KIAA1267; KDVS; hMSL1v1; MLL1/MLL complex subunit KANS ...... |
Chromosomal Location | 17q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between KANSL1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | KANSL1 |
Name | KAT8 regulatory NSL complex subunit 1 |
Aliases | DKFZP727C091; MSL1v1; CENP-36; centromere protein 36; KIAA1267; KDVS; hMSL1v1; MLL1/MLL complex subunit KANS ...... |
Chromosomal Location | 17q21.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting KANSL1 collected from DrugBank database. |
There is no record. |