Summary | |
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Symbol | KAT6B |
Name | K(lysine) acetyltransferase 6B |
Aliases | querkopf; qkf; Morf; MOZ2; ZC2HC6B; MOZ-related factor; MYST4; MYST histone acetyltransferase (monocytic leu ...... |
Chromosomal Location | 10q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF01853 MOZ/SAS family PF00628 PHD-finger |
Function |
Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. |
Biological Process |
GO:0006323 DNA packaging GO:0006333 chromatin assembly or disassembly GO:0006334 nucleosome assembly GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0016570 histone modification GO:0016573 histone acetylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0031497 chromatin assembly GO:0034728 nucleosome organization GO:0043543 protein acylation GO:0043966 histone H3 acetylation GO:0065004 protein-DNA complex assembly GO:0071103 DNA conformation change GO:0071824 protein-DNA complex subunit organization |
Molecular Function |
GO:0004402 histone acetyltransferase activity GO:0008080 N-acetyltransferase activity GO:0008134 transcription factor binding GO:0016407 acetyltransferase activity GO:0016410 N-acyltransferase activity GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0034212 peptide N-acetyltransferase activity GO:0061733 peptide-lysine-N-acetyltransferase activity |
Cellular Component |
GO:0000123 histone acetyltransferase complex GO:0000785 chromatin GO:0000786 nucleosome GO:0031248 protein acetyltransferase complex GO:0032993 protein-DNA complex GO:0044815 DNA packaging complex GO:0070775 H3 histone acetyltransferase complex GO:0070776 MOZ/MORF histone acetyltransferase complex GO:1902493 acetyltransferase complex |
KEGG | - |
Reactome |
R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214847: HATs acetylate histones |
Summary | |
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Symbol | KAT6B |
Name | K(lysine) acetyltransferase 6B |
Aliases | querkopf; qkf; Morf; MOZ2; ZC2HC6B; MOZ-related factor; MYST4; MYST histone acetyltransferase (monocytic leu ...... |
Chromosomal Location | 10q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between KAT6B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | KAT6B |
Name | K(lysine) acetyltransferase 6B |
Aliases | querkopf; qkf; Morf; MOZ2; ZC2HC6B; MOZ-related factor; MYST4; MYST histone acetyltransferase (monocytic leu ...... |
Chromosomal Location | 10q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of KAT6B in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | KAT6B |
Name | K(lysine) acetyltransferase 6B |
Aliases | querkopf; qkf; Morf; MOZ2; ZC2HC6B; MOZ-related factor; MYST4; MYST histone acetyltransferase (monocytic leu ...... |
Chromosomal Location | 10q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of KAT6B in various data sets.
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Points in the above scatter plot represent the mutation difference of KAT6B in various data sets.
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Summary | |
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Symbol | KAT6B |
Name | K(lysine) acetyltransferase 6B |
Aliases | querkopf; qkf; Morf; MOZ2; ZC2HC6B; MOZ-related factor; MYST4; MYST histone acetyltransferase (monocytic leu ...... |
Chromosomal Location | 10q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KAT6B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | KAT6B |
Name | K(lysine) acetyltransferase 6B |
Aliases | querkopf; qkf; Morf; MOZ2; ZC2HC6B; MOZ-related factor; MYST4; MYST histone acetyltransferase (monocytic leu ...... |
Chromosomal Location | 10q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KAT6B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KAT6B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | KAT6B |
Name | K(lysine) acetyltransferase 6B |
Aliases | querkopf; qkf; Morf; MOZ2; ZC2HC6B; MOZ-related factor; MYST4; MYST histone acetyltransferase (monocytic leu ...... |
Chromosomal Location | 10q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KAT6B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | KAT6B |
Name | K(lysine) acetyltransferase 6B |
Aliases | querkopf; qkf; Morf; MOZ2; ZC2HC6B; MOZ-related factor; MYST4; MYST histone acetyltransferase (monocytic leu ...... |
Chromosomal Location | 10q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of KAT6B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | KAT6B |
Name | K(lysine) acetyltransferase 6B |
Aliases | querkopf; qkf; Morf; MOZ2; ZC2HC6B; MOZ-related factor; MYST4; MYST histone acetyltransferase (monocytic leu ...... |
Chromosomal Location | 10q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between KAT6B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | KAT6B |
Name | K(lysine) acetyltransferase 6B |
Aliases | querkopf; qkf; Morf; MOZ2; ZC2HC6B; MOZ-related factor; MYST4; MYST histone acetyltransferase (monocytic leu ...... |
Chromosomal Location | 10q22.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting KAT6B collected from DrugBank database. |
There is no record. |