Browse KAT6B

Summary
SymbolKAT6B
NameK(lysine) acetyltransferase 6B
Aliases querkopf; qkf; Morf; MOZ2; ZC2HC6B; MOZ-related factor; MYST4; MYST histone acetyltransferase (monocytic leu ......
Chromosomal Location10q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF01853 MOZ/SAS family
PF00628 PHD-finger
Function

Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.

> Gene Ontology
 
Biological Process GO:0006323 DNA packaging
GO:0006333 chromatin assembly or disassembly
GO:0006334 nucleosome assembly
GO:0006473 protein acetylation
GO:0006475 internal protein amino acid acetylation
GO:0016570 histone modification
GO:0016573 histone acetylation
GO:0018205 peptidyl-lysine modification
GO:0018393 internal peptidyl-lysine acetylation
GO:0018394 peptidyl-lysine acetylation
GO:0031497 chromatin assembly
GO:0034728 nucleosome organization
GO:0043543 protein acylation
GO:0043966 histone H3 acetylation
GO:0065004 protein-DNA complex assembly
GO:0071103 DNA conformation change
GO:0071824 protein-DNA complex subunit organization
Molecular Function GO:0004402 histone acetyltransferase activity
GO:0008080 N-acetyltransferase activity
GO:0008134 transcription factor binding
GO:0016407 acetyltransferase activity
GO:0016410 N-acyltransferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0034212 peptide N-acetyltransferase activity
GO:0061733 peptide-lysine-N-acetyltransferase activity
Cellular Component GO:0000123 histone acetyltransferase complex
GO:0000785 chromatin
GO:0000786 nucleosome
GO:0031248 protein acetyltransferase complex
GO:0032993 protein-DNA complex
GO:0044815 DNA packaging complex
GO:0070775 H3 histone acetyltransferase complex
GO:0070776 MOZ/MORF histone acetyltransferase complex
GO:1902493 acetyltransferase complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-3214847: HATs acetylate histones
Summary
SymbolKAT6B
NameK(lysine) acetyltransferase 6B
Aliases querkopf; qkf; Morf; MOZ2; ZC2HC6B; MOZ-related factor; MYST4; MYST histone acetyltransferase (monocytic leu ......
Chromosomal Location10q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between KAT6B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolKAT6B
NameK(lysine) acetyltransferase 6B
Aliases querkopf; qkf; Morf; MOZ2; ZC2HC6B; MOZ-related factor; MYST4; MYST histone acetyltransferase (monocytic leu ......
Chromosomal Location10q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of KAT6B in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolKAT6B
NameK(lysine) acetyltransferase 6B
Aliases querkopf; qkf; Morf; MOZ2; ZC2HC6B; MOZ-related factor; MYST4; MYST histone acetyltransferase (monocytic leu ......
Chromosomal Location10q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of KAT6B in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.2640.357
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.0150.987
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.470.525
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0030.991
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2240.932
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2830.929
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.4230.185
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.4940.712
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.3460.818
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2770.754
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.1530.314
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0510.493
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of KAT6B in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.8014.80.00448
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.8014.80.00826
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.3014.30.238
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.4015.40.482
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolKAT6B
NameK(lysine) acetyltransferase 6B
Aliases querkopf; qkf; Morf; MOZ2; ZC2HC6B; MOZ-related factor; MYST4; MYST histone acetyltransferase (monocytic leu ......
Chromosomal Location10q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KAT6B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolKAT6B
NameK(lysine) acetyltransferase 6B
Aliases querkopf; qkf; Morf; MOZ2; ZC2HC6B; MOZ-related factor; MYST4; MYST histone acetyltransferase (monocytic leu ......
Chromosomal Location10q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KAT6B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KAT6B.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolKAT6B
NameK(lysine) acetyltransferase 6B
Aliases querkopf; qkf; Morf; MOZ2; ZC2HC6B; MOZ-related factor; MYST4; MYST histone acetyltransferase (monocytic leu ......
Chromosomal Location10q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KAT6B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolKAT6B
NameK(lysine) acetyltransferase 6B
Aliases querkopf; qkf; Morf; MOZ2; ZC2HC6B; MOZ-related factor; MYST4; MYST histone acetyltransferase (monocytic leu ......
Chromosomal Location10q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of KAT6B expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolKAT6B
NameK(lysine) acetyltransferase 6B
Aliases querkopf; qkf; Morf; MOZ2; ZC2HC6B; MOZ-related factor; MYST4; MYST histone acetyltransferase (monocytic leu ......
Chromosomal Location10q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between KAT6B and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolKAT6B
NameK(lysine) acetyltransferase 6B
Aliases querkopf; qkf; Morf; MOZ2; ZC2HC6B; MOZ-related factor; MYST4; MYST histone acetyltransferase (monocytic leu ......
Chromosomal Location10q22.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting KAT6B collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.