Browse KCND3

Summary
SymbolKCND3
Namepotassium channel, voltage gated Shal related subfamily D, member 3
Aliases Kv4.3; KSHIVB; SCA22; SCA19; spinocerebellar ataxia 22; spinocerebellar ataxia 19; potassium voltage-gated c ......
Chromosomal Location1p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Multi-pass membrane protein Cell membrane, sarcolemma Multi-pass membrane protein Cell projection, dendrite Note=Interaction with palmitoylated KCNIP2 and KCNIP3 enhances cell surface expression.
Domain PF02214 BTB/POZ domain
PF11879 Domain of unknown function (DUF3399)
PF00520 Ion transport protein
PF11601 Shal-type voltage-gated potassium channels
Function

Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.

> Gene Ontology
 
Biological Process GO:0003013 circulatory system process
GO:0003015 heart process
GO:0006813 potassium ion transport
GO:0008015 blood circulation
GO:0008016 regulation of heart contraction
GO:0015672 monovalent inorganic cation transport
GO:0034762 regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0035637 multicellular organismal signaling
GO:0042391 regulation of membrane potential
GO:0044057 regulation of system process
GO:0051259 protein oligomerization
GO:0051260 protein homooligomerization
GO:0060047 heart contraction
GO:0061337 cardiac conduction
GO:0071435 potassium ion export
GO:0071804 cellular potassium ion transport
GO:0071805 potassium ion transmembrane transport
GO:0086009 membrane repolarization
GO:1903522 regulation of blood circulation
Molecular Function GO:0005216 ion channel activity
GO:0005244 voltage-gated ion channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005250 A-type (transient outward) potassium channel activity
GO:0005261 cation channel activity
GO:0005267 potassium channel activity
GO:0015077 monovalent inorganic cation transmembrane transporter activity
GO:0015079 potassium ion transmembrane transporter activity
GO:0015267 channel activity
GO:0015271 outward rectifier potassium channel activity
GO:0022803 passive transmembrane transporter activity
GO:0022832 voltage-gated channel activity
GO:0022836 gated channel activity
GO:0022838 substrate-specific channel activity
GO:0022843 voltage-gated cation channel activity
GO:0044325 ion channel binding
GO:0046873 metal ion transmembrane transporter activity
Cellular Component GO:0008076 voltage-gated potassium channel complex
GO:0030425 dendrite
GO:0034702 ion channel complex
GO:0034703 cation channel complex
GO:0034705 potassium channel complex
GO:0042383 sarcolemma
GO:1902495 transmembrane transporter complex
GO:1990351 transporter complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-5576891: Cardiac conduction
R-HSA-397014: Muscle contraction
R-HSA-112316: Neuronal System
R-HSA-5576894: Phase 1 - inactivation of fast Na+ channels
R-HSA-1296071: Potassium Channels
R-HSA-1296072: Voltage gated Potassium channels
Summary
SymbolKCND3
Namepotassium channel, voltage gated Shal related subfamily D, member 3
Aliases Kv4.3; KSHIVB; SCA22; SCA19; spinocerebellar ataxia 22; spinocerebellar ataxia 19; potassium voltage-gated c ......
Chromosomal Location1p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between KCND3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolKCND3
Namepotassium channel, voltage gated Shal related subfamily D, member 3
Aliases Kv4.3; KSHIVB; SCA22; SCA19; spinocerebellar ataxia 22; spinocerebellar ataxia 19; potassium voltage-gated c ......
Chromosomal Location1p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of KCND3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolKCND3
Namepotassium channel, voltage gated Shal related subfamily D, member 3
Aliases Kv4.3; KSHIVB; SCA22; SCA19; spinocerebellar ataxia 22; spinocerebellar ataxia 19; potassium voltage-gated c ......
Chromosomal Location1p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of KCND3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1660.549
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0230.962
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3130.507
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.6230.329
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.3150.84
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.0080.617
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0590.938
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.1050.362
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-1.3180.26
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0670.913
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.1590.844
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-1.1258.34e-07
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of KCND3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 414250250.222
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277302.7-2.71
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275903.4-3.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21171911.87.20.672
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131123.118.24.91
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.93.74.20.636
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.27.1-0.91
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolKCND3
Namepotassium channel, voltage gated Shal related subfamily D, member 3
Aliases Kv4.3; KSHIVB; SCA22; SCA19; spinocerebellar ataxia 22; spinocerebellar ataxia 19; potassium voltage-gated c ......
Chromosomal Location1p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KCND3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolKCND3
Namepotassium channel, voltage gated Shal related subfamily D, member 3
Aliases Kv4.3; KSHIVB; SCA22; SCA19; spinocerebellar ataxia 22; spinocerebellar ataxia 19; potassium voltage-gated c ......
Chromosomal Location1p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KCND3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KCND3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolKCND3
Namepotassium channel, voltage gated Shal related subfamily D, member 3
Aliases Kv4.3; KSHIVB; SCA22; SCA19; spinocerebellar ataxia 22; spinocerebellar ataxia 19; potassium voltage-gated c ......
Chromosomal Location1p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KCND3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolKCND3
Namepotassium channel, voltage gated Shal related subfamily D, member 3
Aliases Kv4.3; KSHIVB; SCA22; SCA19; spinocerebellar ataxia 22; spinocerebellar ataxia 19; potassium voltage-gated c ......
Chromosomal Location1p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of KCND3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolKCND3
Namepotassium channel, voltage gated Shal related subfamily D, member 3
Aliases Kv4.3; KSHIVB; SCA22; SCA19; spinocerebellar ataxia 22; spinocerebellar ataxia 19; potassium voltage-gated c ......
Chromosomal Location1p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between KCND3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolKCND3
Namepotassium channel, voltage gated Shal related subfamily D, member 3
Aliases Kv4.3; KSHIVB; SCA22; SCA19; spinocerebellar ataxia 22; spinocerebellar ataxia 19; potassium voltage-gated c ......
Chromosomal Location1p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting KCND3 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting KCND3.
ID Name Drug Type Targets #Targets
DB00280DisopyramideSmall MoleculeCHRM1, CHRM2, CHRM3, KCND2, KCND3, KCNH2, ORM2, SCN5A8
DB00321AmitriptylineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, ......35
DB00458ImipramineSmall MoleculeADRA1A, ADRA1B, ADRA1D, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, D ......25
DB06217VernakalantSmall MoleculeKCNA5, KCND3, KCNH2, SCN5A4
DB06637DalfampridineSmall MoleculeKCNA1, KCNA10, KCNA2, KCNA3, KCNA4, KCNA5, KCNA6, KCNA7, KCNB1, KC ......16
DB11633IsavuconazoleSmall MoleculeCACNA1C, KCNA5, KCND3, KCNH2, KCNJ11, KCNJ6, KCNJ9, KCNQ1, SCN5A9