Summary | |
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Symbol | KDM1A |
Name | lysine (K)-specific demethylase 1A |
Aliases | KIAA0601; BHC110; LSD1; AOF2; KDM1; amine oxidase (flavin containing) domain 2; lysine (K)-specific demethyl ...... |
Chromosomal Location | 1p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF01593 Flavin containing amine oxidoreductase PF04433 SWIRM domain |
Function |
Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7. |
Biological Process |
GO:0000018 regulation of DNA recombination GO:0000375 RNA splicing, via transesterification reactions GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile GO:0000380 alternative mRNA splicing, via spliceosome GO:0000398 mRNA splicing, via spliceosome GO:0000724 double-strand break repair via homologous recombination GO:0000725 recombinational repair GO:0001701 in utero embryonic development GO:0002262 myeloid cell homeostasis GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0006144 purine nucleobase metabolic process GO:0006282 regulation of DNA repair GO:0006302 double-strand break repair GO:0006310 DNA recombination GO:0006397 mRNA processing GO:0006476 protein deacetylation GO:0006479 protein methylation GO:0006482 protein demethylation GO:0007596 blood coagulation GO:0007599 hemostasis GO:0008213 protein alkylation GO:0008214 protein dealkylation GO:0008361 regulation of cell size GO:0008380 RNA splicing GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage GO:0009112 nucleobase metabolic process GO:0009314 response to radiation GO:0009411 response to UV GO:0009416 response to light stimulus GO:0009636 response to toxic substance GO:0010212 response to ionizing radiation GO:0010332 response to gamma radiation GO:0010569 regulation of double-strand break repair via homologous recombination GO:0010720 positive regulation of cell development GO:0010725 regulation of primitive erythrocyte differentiation GO:0010817 regulation of hormone levels GO:0010975 regulation of neuron projection development GO:0010976 positive regulation of neuron projection development GO:0014074 response to purine-containing compound GO:0016570 histone modification GO:0016571 histone methylation GO:0016574 histone ubiquitination GO:0016575 histone deacetylation GO:0016577 histone demethylation GO:0018022 peptidyl-lysine methylation GO:0018205 peptidyl-lysine modification GO:0021536 diencephalon development GO:0021537 telencephalon development GO:0021543 pallium development GO:0021700 developmental maturation GO:0021983 pituitary gland development GO:0021987 cerebral cortex development GO:0030099 myeloid cell differentiation GO:0030218 erythrocyte differentiation GO:0030219 megakaryocyte differentiation GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0030851 granulocyte differentiation GO:0030900 forebrain development GO:0031056 regulation of histone modification GO:0031057 negative regulation of histone modification GO:0031058 positive regulation of histone modification GO:0031060 regulation of histone methylation GO:0031061 negative regulation of histone methylation GO:0031346 positive regulation of cell projection organization GO:0031396 regulation of protein ubiquitination GO:0031398 positive regulation of protein ubiquitination GO:0032091 negative regulation of protein binding GO:0032259 methylation GO:0032350 regulation of hormone metabolic process GO:0032352 positive regulation of hormone metabolic process GO:0032535 regulation of cellular component size GO:0032844 regulation of homeostatic process GO:0032846 positive regulation of homeostatic process GO:0033169 histone H3-K9 demethylation GO:0033182 regulation of histone ubiquitination GO:0033184 positive regulation of histone ubiquitination GO:0034101 erythrocyte homeostasis GO:0034644 cellular response to UV GO:0034720 histone H3-K4 demethylation GO:0034968 histone lysine methylation GO:0035162 embryonic hemopoiesis GO:0035270 endocrine system development GO:0035561 regulation of chromatin binding GO:0035563 positive regulation of chromatin binding GO:0035601 protein deacylation GO:0042445 hormone metabolic process GO:0042446 hormone biosynthetic process GO:0042551 neuron maturation GO:0042692 muscle cell differentiation GO:0042770 signal transduction in response to DNA damage GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0043392 negative regulation of DNA binding GO:0043393 regulation of protein binding GO:0043414 macromolecule methylation GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator GO:0045637 regulation of myeloid cell differentiation GO:0045639 positive regulation of myeloid cell differentiation GO:0045646 regulation of erythrocyte differentiation GO:0045648 positive regulation of erythrocyte differentiation GO:0045652 regulation of megakaryocyte differentiation GO:0045654 positive regulation of megakaryocyte differentiation GO:0045666 positive regulation of neuron differentiation GO:0045793 positive regulation of cell size GO:0045995 regulation of embryonic development GO:0046098 guanine metabolic process GO:0046683 response to organophosphorus GO:0046885 regulation of hormone biosynthetic process GO:0046886 positive regulation of hormone biosynthetic process GO:0048469 cell maturation GO:0048568 embryonic organ development GO:0048732 gland development GO:0048872 homeostasis of number of cells GO:0050769 positive regulation of neurogenesis GO:0050817 coagulation GO:0050878 regulation of body fluid levels GO:0051052 regulation of DNA metabolic process GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051098 regulation of binding GO:0051099 positive regulation of binding GO:0051100 negative regulation of binding GO:0051101 regulation of DNA binding GO:0051567 histone H3-K9 methylation GO:0051568 histone H3-K4 methylation GO:0051569 regulation of histone H3-K4 methylation GO:0051570 regulation of histone H3-K9 methylation GO:0051572 negative regulation of histone H3-K4 methylation GO:0051573 negative regulation of histone H3-K9 methylation GO:0051591 response to cAMP GO:0051962 positive regulation of nervous system development GO:0055001 muscle cell development GO:0060215 primitive hemopoiesis GO:0060319 primitive erythrocyte differentiation GO:0060992 response to fungicide GO:0061351 neural precursor cell proliferation GO:0061647 histone H3-K9 modification GO:0070076 histone lysine demethylation GO:0070988 demethylation GO:0071214 cellular response to abiotic stimulus GO:0071320 cellular response to cAMP GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071478 cellular response to radiation GO:0071479 cellular response to ionizing radiation GO:0071480 cellular response to gamma radiation GO:0071482 cellular response to light stimulus GO:0072089 stem cell proliferation GO:0072091 regulation of stem cell proliferation GO:0072331 signal transduction by p53 class mediator GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator GO:0090066 regulation of anatomical structure size GO:0097193 intrinsic apoptotic signaling pathway GO:0098732 macromolecule deacylation GO:1901796 regulation of signal transduction by p53 class mediator GO:1901797 negative regulation of signal transduction by p53 class mediator GO:1902165 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902229 regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902253 regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902275 regulation of chromatin organization GO:1902532 negative regulation of intracellular signal transduction GO:1903320 regulation of protein modification by small protein conjugation or removal GO:1903322 positive regulation of protein modification by small protein conjugation or removal GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:1905268 negative regulation of chromatin organization GO:1905269 positive regulation of chromatin organization GO:2000177 regulation of neural precursor cell proliferation GO:2000179 positive regulation of neural precursor cell proliferation GO:2000648 positive regulation of stem cell proliferation GO:2000779 regulation of double-strand break repair GO:2001020 regulation of response to DNA damage stimulus GO:2001021 negative regulation of response to DNA damage stimulus GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001242 regulation of intrinsic apoptotic signaling pathway GO:2001243 negative regulation of intrinsic apoptotic signaling pathway |
Molecular Function |
GO:0001085 RNA polymerase II transcription factor binding GO:0002039 p53 binding GO:0003682 chromatin binding GO:0003713 transcription coactivator activity GO:0004407 histone deacetylase activity GO:0008134 transcription factor binding GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0019213 deacetylase activity GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity GO:0032451 demethylase activity GO:0032452 histone demethylase activity GO:0032453 histone demethylase activity (H3-K4 specific) GO:0032454 histone demethylase activity (H3-K9 specific) GO:0033558 protein deacetylase activity GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific) GO:0035257 nuclear hormone receptor binding GO:0035258 steroid hormone receptor binding GO:0042162 telomeric DNA binding GO:0043425 bHLH transcription factor binding GO:0043426 MRF binding GO:0048037 cofactor binding GO:0050660 flavin adenine dinucleotide binding GO:0050662 coenzyme binding GO:0050681 androgen receptor binding GO:0051427 hormone receptor binding GO:0061752 telomeric repeat-containing RNA binding |
Cellular Component |
GO:0000781 chromosome, telomeric region GO:0000784 nuclear chromosome, telomeric region GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0005667 transcription factor complex GO:0044454 nuclear chromosome part GO:0098687 chromosomal region GO:1990391 DNA repair complex |
KEGG | - |
Reactome |
R-HSA-5625886: Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-983231: Factors involved in megakaryocyte development and platelet production R-HSA-3214815: HDACs deacetylate histones R-HSA-3214842: HDMs demethylate histones R-HSA-109582: Hemostasis R-HSA-195258: RHO GTPase Effectors R-HSA-5625740: RHO GTPases activate PKNs R-HSA-162582: Signal Transduction R-HSA-194315: Signaling by Rho GTPases |
Summary | |
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Symbol | KDM1A |
Name | lysine (K)-specific demethylase 1A |
Aliases | KIAA0601; BHC110; LSD1; AOF2; KDM1; amine oxidase (flavin containing) domain 2; lysine (K)-specific demethyl ...... |
Chromosomal Location | 1p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between KDM1A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | KDM1A |
Name | lysine (K)-specific demethylase 1A |
Aliases | KIAA0601; BHC110; LSD1; AOF2; KDM1; amine oxidase (flavin containing) domain 2; lysine (K)-specific demethyl ...... |
Chromosomal Location | 1p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of KDM1A in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | KDM1A |
Name | lysine (K)-specific demethylase 1A |
Aliases | KIAA0601; BHC110; LSD1; AOF2; KDM1; amine oxidase (flavin containing) domain 2; lysine (K)-specific demethyl ...... |
Chromosomal Location | 1p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of KDM1A in various data sets.
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Points in the above scatter plot represent the mutation difference of KDM1A in various data sets.
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Summary | |
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Symbol | KDM1A |
Name | lysine (K)-specific demethylase 1A |
Aliases | KIAA0601; BHC110; LSD1; AOF2; KDM1; amine oxidase (flavin containing) domain 2; lysine (K)-specific demethyl ...... |
Chromosomal Location | 1p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KDM1A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | KDM1A |
Name | lysine (K)-specific demethylase 1A |
Aliases | KIAA0601; BHC110; LSD1; AOF2; KDM1; amine oxidase (flavin containing) domain 2; lysine (K)-specific demethyl ...... |
Chromosomal Location | 1p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KDM1A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KDM1A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | KDM1A |
Name | lysine (K)-specific demethylase 1A |
Aliases | KIAA0601; BHC110; LSD1; AOF2; KDM1; amine oxidase (flavin containing) domain 2; lysine (K)-specific demethyl ...... |
Chromosomal Location | 1p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KDM1A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | KDM1A |
Name | lysine (K)-specific demethylase 1A |
Aliases | KIAA0601; BHC110; LSD1; AOF2; KDM1; amine oxidase (flavin containing) domain 2; lysine (K)-specific demethyl ...... |
Chromosomal Location | 1p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of KDM1A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | KDM1A |
Name | lysine (K)-specific demethylase 1A |
Aliases | KIAA0601; BHC110; LSD1; AOF2; KDM1; amine oxidase (flavin containing) domain 2; lysine (K)-specific demethyl ...... |
Chromosomal Location | 1p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between KDM1A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | KDM1A |
Name | lysine (K)-specific demethylase 1A |
Aliases | KIAA0601; BHC110; LSD1; AOF2; KDM1; amine oxidase (flavin containing) domain 2; lysine (K)-specific demethyl ...... |
Chromosomal Location | 1p36.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting KDM1A collected from DrugBank database. |
There is no record. |