Summary | |
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Symbol | KDM1B |
Name | lysine (K)-specific demethylase 1B |
Aliases | FLJ34109; FLJ33898; dJ298J15.2; bA204B7.3; FLJ43328; LSD2; C6orf193; AOF1; amine oxidase, flavin containing ...... |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF01593 Flavin containing amine oxidoreductase PF04433 SWIRM domain PF07496 CW-type Zinc Finger |
Function |
Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. |
Biological Process |
GO:0006304 DNA modification GO:0006305 DNA alkylation GO:0006306 DNA methylation GO:0006349 regulation of gene expression by genetic imprinting GO:0006482 protein demethylation GO:0008214 protein dealkylation GO:0016570 histone modification GO:0016577 histone demethylation GO:0032259 methylation GO:0034720 histone H3-K4 demethylation GO:0040029 regulation of gene expression, epigenetic GO:0043046 DNA methylation involved in gamete generation GO:0043414 macromolecule methylation GO:0044030 regulation of DNA methylation GO:0044728 DNA methylation or demethylation GO:0051052 regulation of DNA metabolic process GO:0070076 histone lysine demethylation GO:0070988 demethylation GO:0071514 genetic imprinting |
Molecular Function |
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0032451 demethylase activity GO:0032452 histone demethylase activity GO:0032453 histone demethylase activity (H3-K4 specific) GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific) GO:0034649 histone demethylase activity (H3-monomethyl-K4 specific) GO:0048037 cofactor binding GO:0050660 flavin adenine dinucleotide binding GO:0050662 coenzyme binding |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-5688426: Deubiquitination R-HSA-3214842: HDMs demethylate histones R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-5689603: UCH proteinases |
Summary | |
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Symbol | KDM1B |
Name | lysine (K)-specific demethylase 1B |
Aliases | FLJ34109; FLJ33898; dJ298J15.2; bA204B7.3; FLJ43328; LSD2; C6orf193; AOF1; amine oxidase, flavin containing ...... |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between KDM1B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | KDM1B |
Name | lysine (K)-specific demethylase 1B |
Aliases | FLJ34109; FLJ33898; dJ298J15.2; bA204B7.3; FLJ43328; LSD2; C6orf193; AOF1; amine oxidase, flavin containing ...... |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of KDM1B in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | KDM1B |
Name | lysine (K)-specific demethylase 1B |
Aliases | FLJ34109; FLJ33898; dJ298J15.2; bA204B7.3; FLJ43328; LSD2; C6orf193; AOF1; amine oxidase, flavin containing ...... |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of KDM1B in various data sets.
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Points in the above scatter plot represent the mutation difference of KDM1B in various data sets.
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Summary | |
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Symbol | KDM1B |
Name | lysine (K)-specific demethylase 1B |
Aliases | FLJ34109; FLJ33898; dJ298J15.2; bA204B7.3; FLJ43328; LSD2; C6orf193; AOF1; amine oxidase, flavin containing ...... |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KDM1B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | KDM1B |
Name | lysine (K)-specific demethylase 1B |
Aliases | FLJ34109; FLJ33898; dJ298J15.2; bA204B7.3; FLJ43328; LSD2; C6orf193; AOF1; amine oxidase, flavin containing ...... |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KDM1B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KDM1B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | KDM1B |
Name | lysine (K)-specific demethylase 1B |
Aliases | FLJ34109; FLJ33898; dJ298J15.2; bA204B7.3; FLJ43328; LSD2; C6orf193; AOF1; amine oxidase, flavin containing ...... |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KDM1B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | KDM1B |
Name | lysine (K)-specific demethylase 1B |
Aliases | FLJ34109; FLJ33898; dJ298J15.2; bA204B7.3; FLJ43328; LSD2; C6orf193; AOF1; amine oxidase, flavin containing ...... |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of KDM1B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | KDM1B |
Name | lysine (K)-specific demethylase 1B |
Aliases | FLJ34109; FLJ33898; dJ298J15.2; bA204B7.3; FLJ43328; LSD2; C6orf193; AOF1; amine oxidase, flavin containing ...... |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between KDM1B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | KDM1B |
Name | lysine (K)-specific demethylase 1B |
Aliases | FLJ34109; FLJ33898; dJ298J15.2; bA204B7.3; FLJ43328; LSD2; C6orf193; AOF1; amine oxidase, flavin containing ...... |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting KDM1B collected from DrugBank database. |
There is no record. |