Summary | |
---|---|
Symbol | KHK |
Name | ketohexokinase (fructokinase) |
Aliases | hepatic fructokinase; Ketohexokinase |
Chromosomal Location | 2p23.3-p23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF00294 pfkB family carbohydrate kinase |
Function |
Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate. |
Biological Process |
GO:0005996 monosaccharide metabolic process GO:0006000 fructose metabolic process GO:0006001 fructose catabolic process GO:0006081 cellular aldehyde metabolic process GO:0009743 response to carbohydrate GO:0009744 response to sucrose GO:0009746 response to hexose GO:0009749 response to glucose GO:0009750 response to fructose GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010043 response to zinc ion GO:0016052 carbohydrate catabolic process GO:0019318 hexose metabolic process GO:0019320 hexose catabolic process GO:0019682 glyceraldehyde-3-phosphate metabolic process GO:0032868 response to insulin GO:0034284 response to monosaccharide GO:0034285 response to disaccharide GO:0043434 response to peptide hormone GO:0044262 cellular carbohydrate metabolic process GO:0044282 small molecule catabolic process GO:0044723 single-organism carbohydrate metabolic process GO:0044724 single-organism carbohydrate catabolic process GO:0046365 monosaccharide catabolic process GO:0046835 carbohydrate phosphorylation GO:0061624 fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate GO:1901652 response to peptide GO:1990267 response to transition metal nanoparticle |
Molecular Function |
GO:0004454 ketohexokinase activity GO:0019200 carbohydrate kinase activity |
Cellular Component | - |
KEGG |
hsa00051 Fructose and mannose metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-70350: Fructose catabolism R-HSA-5652084: Fructose metabolism R-HSA-1430728: Metabolism R-HSA-71387: Metabolism of carbohydrates |
Summary | |
---|---|
Symbol | KHK |
Name | ketohexokinase (fructokinase) |
Aliases | hepatic fructokinase; Ketohexokinase |
Chromosomal Location | 2p23.3-p23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between KHK and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | KHK |
Name | ketohexokinase (fructokinase) |
Aliases | hepatic fructokinase; Ketohexokinase |
Chromosomal Location | 2p23.3-p23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of KHK in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | KHK |
Name | ketohexokinase (fructokinase) |
Aliases | hepatic fructokinase; Ketohexokinase |
Chromosomal Location | 2p23.3-p23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of KHK in various data sets.
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Points in the above scatter plot represent the mutation difference of KHK in various data sets.
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Summary | |
---|---|
Symbol | KHK |
Name | ketohexokinase (fructokinase) |
Aliases | hepatic fructokinase; Ketohexokinase |
Chromosomal Location | 2p23.3-p23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KHK. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | KHK |
Name | ketohexokinase (fructokinase) |
Aliases | hepatic fructokinase; Ketohexokinase |
Chromosomal Location | 2p23.3-p23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KHK. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KHK. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | KHK |
Name | ketohexokinase (fructokinase) |
Aliases | hepatic fructokinase; Ketohexokinase |
Chromosomal Location | 2p23.3-p23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KHK. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | KHK |
Name | ketohexokinase (fructokinase) |
Aliases | hepatic fructokinase; Ketohexokinase |
Chromosomal Location | 2p23.3-p23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of KHK expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | KHK |
Name | ketohexokinase (fructokinase) |
Aliases | hepatic fructokinase; Ketohexokinase |
Chromosomal Location | 2p23.3-p23.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between KHK and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |