Summary | |
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Symbol | KIAA0319 |
Name | KIAA0319 |
Aliases | neuronal migration; DYLX2; Dyslexia-associated protein KIAA0319 |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein Early endosome membrane Single-pass type I membrane protein Note=Low-abundance isoforms lacking the transmembrane domain have been described; these are secreted. |
Domain |
PF02010 REJ domain |
Function |
Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites. |
Biological Process |
GO:0001764 neuron migration GO:0010721 negative regulation of cell development GO:0010975 regulation of neuron projection development GO:0010977 negative regulation of neuron projection development GO:0016358 dendrite development GO:0031345 negative regulation of cell projection organization GO:0045665 negative regulation of neuron differentiation GO:0050768 negative regulation of neurogenesis GO:0050773 regulation of dendrite development GO:0051961 negative regulation of nervous system development GO:2000171 negative regulation of dendrite development |
Molecular Function | - |
Cellular Component |
GO:0005769 early endosome GO:0010008 endosome membrane GO:0031901 early endosome membrane GO:0044440 endosomal part |
KEGG | - |
Reactome |
R-HSA-8856825: Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828: Clathrin-mediated endocytosis R-HSA-199991: Membrane Trafficking R-HSA-5653656: Vesicle-mediated transport |
Summary | |
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Symbol | KIAA0319 |
Name | KIAA0319 |
Aliases | neuronal migration; DYLX2; Dyslexia-associated protein KIAA0319 |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between KIAA0319 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | KIAA0319 |
Name | KIAA0319 |
Aliases | neuronal migration; DYLX2; Dyslexia-associated protein KIAA0319 |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of KIAA0319 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | KIAA0319 |
Name | KIAA0319 |
Aliases | neuronal migration; DYLX2; Dyslexia-associated protein KIAA0319 |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of KIAA0319 in various data sets.
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Points in the above scatter plot represent the mutation difference of KIAA0319 in various data sets.
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Summary | |
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Symbol | KIAA0319 |
Name | KIAA0319 |
Aliases | neuronal migration; DYLX2; Dyslexia-associated protein KIAA0319 |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KIAA0319. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | KIAA0319 |
Name | KIAA0319 |
Aliases | neuronal migration; DYLX2; Dyslexia-associated protein KIAA0319 |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KIAA0319. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KIAA0319. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | KIAA0319 |
Name | KIAA0319 |
Aliases | neuronal migration; DYLX2; Dyslexia-associated protein KIAA0319 |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KIAA0319. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | KIAA0319 |
Name | KIAA0319 |
Aliases | neuronal migration; DYLX2; Dyslexia-associated protein KIAA0319 |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of KIAA0319 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | KIAA0319 |
Name | KIAA0319 |
Aliases | neuronal migration; DYLX2; Dyslexia-associated protein KIAA0319 |
Chromosomal Location | 6p22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between KIAA0319 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |