Browse KIF11

Summary
SymbolKIF11
Namekinesin family member 11
Aliases Eg5; HKSP; TRIP5; KNSL1; kinesin-like 1; MCLMR; TR-interacting protein 5; TRIP-5; kinesin-like protein 1; ki ......
Chromosomal Location10q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Cytoplasm, cytoskeleton, spindle pole
Domain PF00225 Kinesin motor domain
PF13931 Kinesin-associated microtubule-binding
Function

Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769).

> Gene Ontology
 
Biological Process GO:0000226 microtubule cytoskeleton organization
GO:0002478 antigen processing and presentation of exogenous peptide antigen
GO:0002495 antigen processing and presentation of peptide antigen via MHC class II
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
GO:0007018 microtubule-based movement
GO:0007051 spindle organization
GO:0007052 mitotic spindle organization
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0007088 regulation of mitotic nuclear division
GO:0007098 centrosome cycle
GO:0007100 mitotic centrosome separation
GO:0007346 regulation of mitotic cell cycle
GO:0019882 antigen processing and presentation
GO:0019884 antigen processing and presentation of exogenous antigen
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0031023 microtubule organizing center organization
GO:0032886 regulation of microtubule-based process
GO:0046602 regulation of mitotic centrosome separation
GO:0046605 regulation of centrosome cycle
GO:0048002 antigen processing and presentation of peptide antigen
GO:0048193 Golgi vesicle transport
GO:0051225 spindle assembly
GO:0051297 centrosome organization
GO:0051299 centrosome separation
GO:0051493 regulation of cytoskeleton organization
GO:0051783 regulation of nuclear division
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0090307 mitotic spindle assembly
GO:1902850 microtubule cytoskeleton organization involved in mitosis
Molecular Function GO:0003774 motor activity
GO:0003777 microtubule motor activity
GO:0008017 microtubule binding
GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed
GO:0015631 tubulin binding
GO:0016887 ATPase activity
GO:1990939 ATP-dependent microtubule motor activity
Cellular Component GO:0000922 spindle pole
GO:0005819 spindle
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0005876 spindle microtubule
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1280218: Adaptive Immune System
R-HSA-6811434: COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983231: Factors involved in megakaryocyte development and platelet production
R-HSA-8856688: Golgi-to-ER retrograde transport
R-HSA-109582: Hemostasis
R-HSA-168256: Immune System
R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-983189: Kinesins
R-HSA-2132295: MHC class II antigen presentation
R-HSA-199991: Membrane Trafficking
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolKIF11
Namekinesin family member 11
Aliases Eg5; HKSP; TRIP5; KNSL1; kinesin-like 1; MCLMR; TR-interacting protein 5; TRIP-5; kinesin-like protein 1; ki ......
Chromosomal Location10q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between KIF11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolKIF11
Namekinesin family member 11
Aliases Eg5; HKSP; TRIP5; KNSL1; kinesin-like 1; MCLMR; TR-interacting protein 5; TRIP-5; kinesin-like protein 1; ki ......
Chromosomal Location10q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of KIF11 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.97 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolKIF11
Namekinesin family member 11
Aliases Eg5; HKSP; TRIP5; KNSL1; kinesin-like 1; MCLMR; TR-interacting protein 5; TRIP-5; kinesin-like protein 1; ki ......
Chromosomal Location10q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of KIF11 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.2580.387
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.2190.863
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.290.773
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2520.525
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1640.911
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.370.854
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0350.926
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2540.866
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.4580.768
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1210.876
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.2630.812
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.4617.91e-05
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of KIF11 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.11.49.70.0589
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.11.79.40.0895
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59200200.357
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolKIF11
Namekinesin family member 11
Aliases Eg5; HKSP; TRIP5; KNSL1; kinesin-like 1; MCLMR; TR-interacting protein 5; TRIP-5; kinesin-like protein 1; ki ......
Chromosomal Location10q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KIF11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolKIF11
Namekinesin family member 11
Aliases Eg5; HKSP; TRIP5; KNSL1; kinesin-like 1; MCLMR; TR-interacting protein 5; TRIP-5; kinesin-like protein 1; ki ......
Chromosomal Location10q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KIF11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KIF11.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolKIF11
Namekinesin family member 11
Aliases Eg5; HKSP; TRIP5; KNSL1; kinesin-like 1; MCLMR; TR-interacting protein 5; TRIP-5; kinesin-like protein 1; ki ......
Chromosomal Location10q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KIF11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolKIF11
Namekinesin family member 11
Aliases Eg5; HKSP; TRIP5; KNSL1; kinesin-like 1; MCLMR; TR-interacting protein 5; TRIP-5; kinesin-like protein 1; ki ......
Chromosomal Location10q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of KIF11 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolKIF11
Namekinesin family member 11
Aliases Eg5; HKSP; TRIP5; KNSL1; kinesin-like 1; MCLMR; TR-interacting protein 5; TRIP-5; kinesin-like protein 1; ki ......
Chromosomal Location10q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between KIF11 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolKIF11
Namekinesin family member 11
Aliases Eg5; HKSP; TRIP5; KNSL1; kinesin-like 1; MCLMR; TR-interacting protein 5; TRIP-5; kinesin-like protein 1; ki ......
Chromosomal Location10q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting KIF11 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting KIF11.
ID Name Drug Type Targets #Targets
DB039963-[(5s)-1-Acetyl-3-(2-Chlorophenyl)-4,5-Dihydro-1h-Pyrazol-5-Yl]PhenolSmall MoleculeKIF111
DB04331MonastrolSmall MoleculeKIF111
DB06040FilanesibSmall MoleculeKIF111
DB07064(4R)-4-(3-HYDROXYPHENYL)-N,N,7,8-TETRAMETHYL-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDESmall MoleculeKIF111
DB08032N,N-DIETHYL-2-[(2-THIENYLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDESmall MoleculeKIF111
DB08033(5R)-N,N-DIETHYL-5-METHYL-2-[(THIOPHEN-2-YLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDESmall MoleculeKIF111
DB08037(2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamideSmall MoleculeKIF111
DB08198[(4R)-4-(3-HYDROXYPHENYL)-1,6-DIMETHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL](PHENYL)METHANONESmall MoleculeKIF111
DB08239(2S)-4-(2,5-DIFLUOROPHENYL)-N-METHYL-2-PHENYL-N-PIPERIDIN-4-YL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDESmall MoleculeKIF111
DB08244(1S)-1-CYCLOPROPYL-2-[(2S)-4-(2,5-DIFLUOROPHENYL)-2-PHENYL-2,5-DIHYDRO-1H-PYRROL-1-YL]-2-OXOETHANAMINESmall MoleculeKIF111
DB08246(2S)-4-(2,5-DIFLUOROPHENYL)-N,N-DIMETHYL-2-PHENYL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDESmall MoleculeKIF111
DB08250(5S)-5-(3-AMINOPROPYL)-3-(2,5-DIFLUOROPHENYL)-N-ETHYL-5-PHENYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDESmall MoleculeKIF111