Summary | |
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Symbol | KIF11 |
Name | kinesin family member 11 |
Aliases | Eg5; HKSP; TRIP5; KNSL1; kinesin-like 1; MCLMR; TR-interacting protein 5; TRIP-5; kinesin-like protein 1; ki ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Cytoplasm, cytoskeleton, spindle pole |
Domain |
PF00225 Kinesin motor domain PF13931 Kinesin-associated microtubule-binding |
Function |
Motor protein required for establishing a bipolar spindle during mitosis (PubMed:19001501). Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface (PubMed:23857769). |
Biological Process |
GO:0000226 microtubule cytoskeleton organization GO:0002478 antigen processing and presentation of exogenous peptide antigen GO:0002495 antigen processing and presentation of peptide antigen via MHC class II GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0007018 microtubule-based movement GO:0007051 spindle organization GO:0007052 mitotic spindle organization GO:0007059 chromosome segregation GO:0007067 mitotic nuclear division GO:0007088 regulation of mitotic nuclear division GO:0007098 centrosome cycle GO:0007100 mitotic centrosome separation GO:0007346 regulation of mitotic cell cycle GO:0019882 antigen processing and presentation GO:0019884 antigen processing and presentation of exogenous antigen GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0031023 microtubule organizing center organization GO:0032886 regulation of microtubule-based process GO:0046602 regulation of mitotic centrosome separation GO:0046605 regulation of centrosome cycle GO:0048002 antigen processing and presentation of peptide antigen GO:0048193 Golgi vesicle transport GO:0051225 spindle assembly GO:0051297 centrosome organization GO:0051299 centrosome separation GO:0051493 regulation of cytoskeleton organization GO:0051783 regulation of nuclear division GO:0070507 regulation of microtubule cytoskeleton organization GO:0090307 mitotic spindle assembly GO:1902850 microtubule cytoskeleton organization involved in mitosis |
Molecular Function |
GO:0003774 motor activity GO:0003777 microtubule motor activity GO:0008017 microtubule binding GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed GO:0015631 tubulin binding GO:0016887 ATPase activity GO:1990939 ATP-dependent microtubule motor activity |
Cellular Component |
GO:0000922 spindle pole GO:0005819 spindle GO:0005871 kinesin complex GO:0005874 microtubule GO:0005875 microtubule associated complex GO:0005876 spindle microtubule |
KEGG | - |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-6811434: COPI-dependent Golgi-to-ER retrograde traffic R-HSA-983231: Factors involved in megakaryocyte development and platelet production R-HSA-8856688: Golgi-to-ER retrograde transport R-HSA-109582: Hemostasis R-HSA-168256: Immune System R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-983189: Kinesins R-HSA-2132295: MHC class II antigen presentation R-HSA-199991: Membrane Trafficking R-HSA-5653656: Vesicle-mediated transport |
Summary | |
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Symbol | KIF11 |
Name | kinesin family member 11 |
Aliases | Eg5; HKSP; TRIP5; KNSL1; kinesin-like 1; MCLMR; TR-interacting protein 5; TRIP-5; kinesin-like protein 1; ki ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between KIF11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | KIF11 |
Name | kinesin family member 11 |
Aliases | Eg5; HKSP; TRIP5; KNSL1; kinesin-like 1; MCLMR; TR-interacting protein 5; TRIP-5; kinesin-like protein 1; ki ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of KIF11 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | KIF11 |
Name | kinesin family member 11 |
Aliases | Eg5; HKSP; TRIP5; KNSL1; kinesin-like 1; MCLMR; TR-interacting protein 5; TRIP-5; kinesin-like protein 1; ki ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of KIF11 in various data sets.
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Points in the above scatter plot represent the mutation difference of KIF11 in various data sets.
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Summary | |
---|---|
Symbol | KIF11 |
Name | kinesin family member 11 |
Aliases | Eg5; HKSP; TRIP5; KNSL1; kinesin-like 1; MCLMR; TR-interacting protein 5; TRIP-5; kinesin-like protein 1; ki ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KIF11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | KIF11 |
Name | kinesin family member 11 |
Aliases | Eg5; HKSP; TRIP5; KNSL1; kinesin-like 1; MCLMR; TR-interacting protein 5; TRIP-5; kinesin-like protein 1; ki ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KIF11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KIF11. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | KIF11 |
Name | kinesin family member 11 |
Aliases | Eg5; HKSP; TRIP5; KNSL1; kinesin-like 1; MCLMR; TR-interacting protein 5; TRIP-5; kinesin-like protein 1; ki ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KIF11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | KIF11 |
Name | kinesin family member 11 |
Aliases | Eg5; HKSP; TRIP5; KNSL1; kinesin-like 1; MCLMR; TR-interacting protein 5; TRIP-5; kinesin-like protein 1; ki ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of KIF11 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | KIF11 |
Name | kinesin family member 11 |
Aliases | Eg5; HKSP; TRIP5; KNSL1; kinesin-like 1; MCLMR; TR-interacting protein 5; TRIP-5; kinesin-like protein 1; ki ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between KIF11 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | KIF11 |
Name | kinesin family member 11 |
Aliases | Eg5; HKSP; TRIP5; KNSL1; kinesin-like 1; MCLMR; TR-interacting protein 5; TRIP-5; kinesin-like protein 1; ki ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting KIF11 collected from DrugBank database. |
Details on drugs targeting KIF11.
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