Browse KIF14

Summary
SymbolKIF14
Namekinesin family member 14
Aliases KIAA0042; MKS12; Kinesin-like protein KIF14
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Cytoplasm Cytoplasm, cytoskeleton, spindle Midbody Note=Nuclear localization observed during interphase (PubMed:16431929). Nuclear localization triggered by entry into mitosis (PubMed:16648480). Cytoplasmic in interphase (PubMed:16648480). Cytoplasmic in metaphase cells (PubMed:16431929). From prophase to metaphase, accumulates at the developing spindle poles and their associated microtubules. During anaphase, accumulates at the spindle midzone. Localization to the central spindle and midbody during anaphase is dependent upon PRC1 and CIT presence. In cells ready to undergo abscission, concentrates at the contractile ring.
Domain PF00498 FHA domain
PF00225 Kinesin motor domain
PF16183 Kinesin-associated
Function

Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed:24784001, PubMed:16648480). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed:16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed:24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed:24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed:15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed:23209302).

> Gene Ontology
 
Biological Process GO:0000070 mitotic sister chromatid segregation
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000819 sister chromatid segregation
GO:0000910 cytokinesis
GO:0001558 regulation of cell growth
GO:0007018 microtubule-based movement
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0007080 mitotic metaphase plate congression
GO:0007265 Ras protein signal transduction
GO:0007272 ensheathment of neurons
GO:0007346 regulation of mitotic cell cycle
GO:0008366 axon ensheathment
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0010498 proteasomal protein catabolic process
GO:0016049 cell growth
GO:0021537 telencephalon development
GO:0021543 pallium development
GO:0021549 cerebellum development
GO:0021575 hindbrain morphogenesis
GO:0021587 cerebellum morphogenesis
GO:0021680 cerebellar Purkinje cell layer development
GO:0021681 cerebellar granular layer development
GO:0021683 cerebellar granular layer morphogenesis
GO:0021685 cerebellar granular layer structural organization
GO:0021692 cerebellar Purkinje cell layer morphogenesis
GO:0021693 cerebellar Purkinje cell layer structural organization
GO:0021695 cerebellar cortex development
GO:0021696 cerebellar cortex morphogenesis
GO:0021698 cerebellar cortex structural organization
GO:0021700 developmental maturation
GO:0021761 limbic system development
GO:0021766 hippocampus development
GO:0021772 olfactory bulb development
GO:0021846 cell proliferation in forebrain
GO:0021987 cerebral cortex development
GO:0021988 olfactory lobe development
GO:0022037 metencephalon development
GO:0030705 cytoskeleton-dependent intracellular transport
GO:0030900 forebrain development
GO:0030902 hindbrain development
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031333 negative regulation of protein complex assembly
GO:0031589 cell-substrate adhesion
GO:0031641 regulation of myelination
GO:0032147 activation of protein kinase activity
GO:0032465 regulation of cytokinesis
GO:0032467 positive regulation of cytokinesis
GO:0032486 Rap protein signal transduction
GO:0032487 regulation of Rap protein signal transduction
GO:0033622 integrin activation
GO:0033623 regulation of integrin activation
GO:0033624 negative regulation of integrin activation
GO:0033674 positive regulation of kinase activity
GO:0034446 substrate adhesion-dependent cell spreading
GO:0042552 myelination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043254 regulation of protein complex assembly
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0044770 cell cycle phase transition
GO:0044772 mitotic cell cycle phase transition
GO:0044839 cell cycle G2/M phase transition
GO:0044843 cell cycle G1/S phase transition
GO:0045787 positive regulation of cell cycle
GO:0045860 positive regulation of protein kinase activity
GO:0046578 regulation of Ras protein signal transduction
GO:0048469 cell maturation
GO:0048532 anatomical structure arrangement
GO:0050000 chromosome localization
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051302 regulation of cell division
GO:0051303 establishment of chromosome localization
GO:0051310 metaphase plate congression
GO:0051402 neuron apoptotic process
GO:0051640 organelle localization
GO:0051656 establishment of organelle localization
GO:0051781 positive regulation of cell division
GO:0061351 neural precursor cell proliferation
GO:0070997 neuron death
GO:0090068 positive regulation of cell cycle process
GO:0098813 nuclear chromosome segregation
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1901987 regulation of cell cycle phase transition
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1902749 regulation of cell cycle G2/M phase transition
GO:1902806 regulation of cell cycle G1/S phase transition
GO:1903429 regulation of cell maturation
GO:2000045 regulation of G1/S transition of mitotic cell cycle
Molecular Function GO:0003774 motor activity
GO:0003777 microtubule motor activity
GO:0008017 microtubule binding
GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed
GO:0015631 tubulin binding
GO:0016887 ATPase activity
GO:0030165 PDZ domain binding
GO:1990939 ATP-dependent microtubule motor activity
Cellular Component GO:0005819 spindle
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0030496 midbody
GO:0051233 spindle midzone
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-195258: RHO GTPase Effectors
R-HSA-5625900: RHO GTPases activate CIT
R-HSA-162582: Signal Transduction
R-HSA-194315: Signaling by Rho GTPases
Summary
SymbolKIF14
Namekinesin family member 14
Aliases KIAA0042; MKS12; Kinesin-like protein KIF14
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between KIF14 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolKIF14
Namekinesin family member 14
Aliases KIAA0042; MKS12; Kinesin-like protein KIF14
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of KIF14 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolKIF14
Namekinesin family member 14
Aliases KIAA0042; MKS12; Kinesin-like protein KIF14
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of KIF14 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.6210.0254
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.5190.458
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.70.242
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1260.809
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0540.972
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2080.922
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0210.958
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.8150.519
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11121.0980.364
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1620.706
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.1130.847
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.4750.000649
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of KIF14 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.14.170.339
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.15.160.373
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.3014.30.238
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.4015.40.482
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59200200.357
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolKIF14
Namekinesin family member 14
Aliases KIAA0042; MKS12; Kinesin-like protein KIF14
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KIF14. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolKIF14
Namekinesin family member 14
Aliases KIAA0042; MKS12; Kinesin-like protein KIF14
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KIF14. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KIF14.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolKIF14
Namekinesin family member 14
Aliases KIAA0042; MKS12; Kinesin-like protein KIF14
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KIF14. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolKIF14
Namekinesin family member 14
Aliases KIAA0042; MKS12; Kinesin-like protein KIF14
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of KIF14 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolKIF14
Namekinesin family member 14
Aliases KIAA0042; MKS12; Kinesin-like protein KIF14
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between KIF14 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolKIF14
Namekinesin family member 14
Aliases KIAA0042; MKS12; Kinesin-like protein KIF14
Chromosomal Location1q32.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting KIF14 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.