TISIDB

Summary
Symbol	KIF1A
Name	kinesin family member 1A
Aliases	UNC104; ATSV; C2orf20; SPG30; axonal transport of synaptic vesicles; chromosome 2 open reading frame 20; spa ......
Chromosomal Location	2q37.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm, cytoskeleton Note=Expressed in distal regions of neurites.
Domain	PF12473 Kinesin protein PF00498 FHA domain PF12423 Kinesin protein 1B PF00225 Kinesin motor domain PF16183 Kinesin-associated PF00169 PH domain
Function	Motor for anterograde axonal transport of synaptic vesicle precursors.

> Gene Ontology [ TOP ]
Biological Process	GO:0007018 microtubule-based movement GO:0008088 axo-dendritic transport GO:0008089 anterograde axonal transport GO:0010970 transport along microtubule GO:0030705 cytoskeleton-dependent intracellular transport GO:0098930 axonal transport
Molecular Function	GO:0003774 motor activity GO:0003777 microtubule motor activity GO:0008017 microtubule binding GO:0015631 tubulin binding GO:0016887 ATPase activity
Cellular Component	GO:0005871 kinesin complex GO:0005874 microtubule GO:0005875 microtubule associated complex GO:0030424 axon GO:0032838 cell projection cytoplasm GO:0033267 axon part GO:0099568 cytoplasmic region GO:1904115 axon cytoplasm

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-6811434: COPI-dependent Golgi-to-ER retrograde traffic R-HSA-983231: Factors involved in megakaryocyte development and platelet production R-HSA-8856688: Golgi-to-ER retrograde transport R-HSA-109582: Hemostasis R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-983189: Kinesins R-HSA-199991: Membrane Trafficking R-HSA-5653656: Vesicle-mediated transport

Summary
Symbol	KIF1A
Name	kinesin family member 1A
Aliases	UNC104; ATSV; C2orf20; SPG30; axonal transport of synaptic vesicles; chromosome 2 open reading frame 20; spa ......
Chromosomal Location	2q37.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between KIF1A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	KIF1A
Name	kinesin family member 1A
Aliases	UNC104; ATSV; C2orf20; SPG30; axonal transport of synaptic vesicles; chromosome 2 open reading frame 20; spa ......
Chromosomal Location	2q37.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of KIF1A in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	KIF1A
Name	kinesin family member 1A
Aliases	UNC104; ATSV; C2orf20; SPG30; axonal transport of synaptic vesicles; chromosome 2 open reading frame 20; spa ......
Chromosomal Location	2q37.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of KIF1A in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-1.06	0.0433
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-1.595	0.0599
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.69	0.335
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.543	0.339
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	1.332	0.412
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.451	0.828
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.67	0.534
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.735	0.631
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.465	0.779
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.119	0.795
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.047	0.944
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.894	0.0417

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of KIF1A in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	21.4	5.9	15.5	0.304
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	20	0	20	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	25	7.1	17.9	0.405
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	6.8	-3.1	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	7.1	-7.1	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	6.8	-3.1	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	9.5	5.9	3.6	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	15.4	9.1	6.3	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	0	11.1	0.36
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	25	0	25	0.364
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	7.9	0	7.9	0.26
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	9.1	0	9.1	0.519
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	6.2	0	6.2	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	KIF1A
Name	kinesin family member 1A
Aliases	UNC104; ATSV; C2orf20; SPG30; axonal transport of synaptic vesicles; chromosome 2 open reading frame 20; spa ......
Chromosomal Location	2q37.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KIF1A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	KIF1A
Name	kinesin family member 1A
Aliases	UNC104; ATSV; C2orf20; SPG30; axonal transport of synaptic vesicles; chromosome 2 open reading frame 20; spa ......
Chromosomal Location	2q37.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KIF1A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KIF1A. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	KIF1A
Name	kinesin family member 1A
Aliases	UNC104; ATSV; C2orf20; SPG30; axonal transport of synaptic vesicles; chromosome 2 open reading frame 20; spa ......
Chromosomal Location	2q37.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KIF1A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	KIF1A
Name	kinesin family member 1A
Aliases	UNC104; ATSV; C2orf20; SPG30; axonal transport of synaptic vesicles; chromosome 2 open reading frame 20; spa ......
Chromosomal Location	2q37.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of KIF1A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	KIF1A
Name	kinesin family member 1A
Aliases	UNC104; ATSV; C2orf20; SPG30; axonal transport of synaptic vesicles; chromosome 2 open reading frame 20; spa ......
Chromosomal Location	2q37.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between KIF1A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	KIF1A
Name	kinesin family member 1A
Aliases	UNC104; ATSV; C2orf20; SPG30; axonal transport of synaptic vesicles; chromosome 2 open reading frame 20; spa ......
Chromosomal Location	2q37.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting KIF1A collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting KIF1A.

ID	Name	Drug Type	Targets	#Targets
DB03909	Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate	Small Molecule	ATP2A1, INSR, KIF1A, PDXK, PGK1	5
DB04395	Phosphoaminophosphonic Acid-Adenylate Ester	Small Molecule	ACTA1, CCT3, CFTR, CSNK2A1, DAPK1, DTYMK, EPHA2, EPHB2, GALK1, GSK ......	26

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