Summary | |
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Symbol | KIF20B |
Name | kinesin family member 20B |
Aliases | KRMP1; cancer/testis antigen 90; MPHOSPH1; M-phase phosphoprotein 1; MPP-1; kinesin-related motor interactin ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Nucleus, nucleolus Nucleus, nucleoplasm Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, spindle pole Midbody Cell projection, axon Cell projection, growth cone Note=Localizes mainly in the nucleus during interphase although it is also detected in the cytoplasm without clear association with microtubules (PubMed:12740395). Localized to the central spindle during cytokinetic furrowing and with the midbody during abscission (PubMed:12740395, PubMed:17409436). A 2-3 fold expression increase is seen as cells progress from G1 to G2/M phase (PubMed:12740395). During prophase and metaphase it is found throughout the cytoplasm and at anaphase accumulates at the midplan of the cell and forms a distinct band extending across the spindle midzone (PubMed:12740395). At anaphase it is concentrated in the midbody (PubMed:12740395). Colocalized partially along microtubules in primary neurons. Colocalized with SHTN1 along microtubules to the tip of the growing cone in primary hippocampal neurons. Localized in midbodies between dividing radial progenitors in the ventricular zone (By similarity). Colocalized with PRC1 in the nucleus of bladder carcinoma cells at the interphase. Colocalized with PRC1 in bladder carcinoma cells at prophase, metaphase, early anaphase, at the midzone in late anaphase and at the contractile ring in telophase (PubMed:17409436). |
Domain |
PF00225 Kinesin motor domain |
Function |
Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). |
Biological Process |
GO:0000281 mitotic cytokinesis GO:0000910 cytokinesis GO:0001764 neuron migration GO:0001838 embryonic epithelial tube formation GO:0001841 neural tube formation GO:0001843 neural tube closure GO:0007018 microtubule-based movement GO:0007050 cell cycle arrest GO:0007067 mitotic nuclear division GO:0007088 regulation of mitotic nuclear division GO:0007163 establishment or maintenance of cell polarity GO:0007346 regulation of mitotic cell cycle GO:0010720 positive regulation of cell development GO:0014020 primary neural tube formation GO:0016331 morphogenesis of embryonic epithelium GO:0021915 neural tube development GO:0030010 establishment of cell polarity GO:0030335 positive regulation of cell migration GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032465 regulation of cytokinesis GO:0032467 positive regulation of cytokinesis GO:0032506 cytokinetic process GO:0032878 regulation of establishment or maintenance of cell polarity GO:0032954 regulation of cytokinetic process GO:0033157 regulation of intracellular protein transport GO:0035148 tube formation GO:0035239 tube morphogenesis GO:0035372 protein localization to microtubule GO:0040017 positive regulation of locomotion GO:0044380 protein localization to cytoskeleton GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0045931 positive regulation of mitotic cell cycle GO:0050769 positive regulation of neurogenesis GO:0051222 positive regulation of protein transport GO:0051272 positive regulation of cellular component movement GO:0051302 regulation of cell division GO:0051781 positive regulation of cell division GO:0051783 regulation of nuclear division GO:0051962 positive regulation of nervous system development GO:0060562 epithelial tube morphogenesis GO:0060606 tube closure GO:0061640 cytoskeleton-dependent cytokinesis GO:0072175 epithelial tube formation GO:0072698 protein localization to microtubule cytoskeleton GO:0090068 positive regulation of cell cycle process GO:0090316 positive regulation of intracellular protein transport GO:1902410 mitotic cytokinetic process GO:1902412 regulation of mitotic cytokinesis GO:1903436 regulation of mitotic cytokinetic process GO:1903438 positive regulation of mitotic cytokinetic process GO:1903490 positive regulation of mitotic cytokinesis GO:1903829 positive regulation of cellular protein localization GO:1904951 positive regulation of establishment of protein localization GO:2000114 regulation of establishment of cell polarity GO:2000147 positive regulation of cell motility GO:2001222 regulation of neuron migration GO:2001224 positive regulation of neuron migration |
Molecular Function |
GO:0003774 motor activity GO:0003777 microtubule motor activity GO:0008017 microtubule binding GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed GO:0015631 tubulin binding GO:0016887 ATPase activity GO:0050699 WW domain binding GO:1990939 ATP-dependent microtubule motor activity |
Cellular Component |
GO:0000922 spindle pole GO:0005813 centrosome GO:0005819 spindle GO:0005871 kinesin complex GO:0005874 microtubule GO:0005875 microtubule associated complex GO:0030424 axon GO:0030426 growth cone GO:0030427 site of polarized growth GO:0030496 midbody GO:0051233 spindle midzone GO:0070938 contractile ring GO:0072686 mitotic spindle GO:0097431 mitotic spindle pole GO:1990023 mitotic spindle midzone |
KEGG | - |
Reactome |
R-HSA-6811434: COPI-dependent Golgi-to-ER retrograde traffic R-HSA-983231: Factors involved in megakaryocyte development and platelet production R-HSA-8856688: Golgi-to-ER retrograde transport R-HSA-109582: Hemostasis R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-983189: Kinesins R-HSA-199991: Membrane Trafficking R-HSA-5653656: Vesicle-mediated transport |
Summary | |
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Symbol | KIF20B |
Name | kinesin family member 20B |
Aliases | KRMP1; cancer/testis antigen 90; MPHOSPH1; M-phase phosphoprotein 1; MPP-1; kinesin-related motor interactin ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between KIF20B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | KIF20B |
Name | kinesin family member 20B |
Aliases | KRMP1; cancer/testis antigen 90; MPHOSPH1; M-phase phosphoprotein 1; MPP-1; kinesin-related motor interactin ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of KIF20B in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | KIF20B |
Name | kinesin family member 20B |
Aliases | KRMP1; cancer/testis antigen 90; MPHOSPH1; M-phase phosphoprotein 1; MPP-1; kinesin-related motor interactin ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of KIF20B in various data sets.
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Points in the above scatter plot represent the mutation difference of KIF20B in various data sets.
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Summary | |
---|---|
Symbol | KIF20B |
Name | kinesin family member 20B |
Aliases | KRMP1; cancer/testis antigen 90; MPHOSPH1; M-phase phosphoprotein 1; MPP-1; kinesin-related motor interactin ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KIF20B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | KIF20B |
Name | kinesin family member 20B |
Aliases | KRMP1; cancer/testis antigen 90; MPHOSPH1; M-phase phosphoprotein 1; MPP-1; kinesin-related motor interactin ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KIF20B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KIF20B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | KIF20B |
Name | kinesin family member 20B |
Aliases | KRMP1; cancer/testis antigen 90; MPHOSPH1; M-phase phosphoprotein 1; MPP-1; kinesin-related motor interactin ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KIF20B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | KIF20B |
Name | kinesin family member 20B |
Aliases | KRMP1; cancer/testis antigen 90; MPHOSPH1; M-phase phosphoprotein 1; MPP-1; kinesin-related motor interactin ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of KIF20B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | KIF20B |
Name | kinesin family member 20B |
Aliases | KRMP1; cancer/testis antigen 90; MPHOSPH1; M-phase phosphoprotein 1; MPP-1; kinesin-related motor interactin ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between KIF20B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | KIF20B |
Name | kinesin family member 20B |
Aliases | KRMP1; cancer/testis antigen 90; MPHOSPH1; M-phase phosphoprotein 1; MPP-1; kinesin-related motor interactin ...... |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting KIF20B collected from DrugBank database. |
There is no record. |