Summary | |
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Symbol | KIFC1 |
Name | kinesin family member C1 |
Aliases | HSET; KNSL2; kinesin-like 2; kinesin-related protein HSET; Kinesin-like protein KIFC1 |
Chromosomal Location | 6p21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Early endosome Note=Associated with nucleus during interphase, centrosomes in early and spindle in later mitosis. |
Domain |
PF00225 Kinesin motor domain |
Function |
Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity). |
Biological Process |
GO:0000070 mitotic sister chromatid segregation GO:0000226 microtubule cytoskeleton organization GO:0000819 sister chromatid segregation GO:0007018 microtubule-based movement GO:0007051 spindle organization GO:0007059 chromosome segregation GO:0007067 mitotic nuclear division GO:0007080 mitotic metaphase plate congression GO:0007283 spermatogenesis GO:0048232 male gamete generation GO:0050000 chromosome localization GO:0051225 spindle assembly GO:0051303 establishment of chromosome localization GO:0051310 metaphase plate congression GO:0051640 organelle localization GO:0051656 establishment of organelle localization GO:0090307 mitotic spindle assembly GO:0098813 nuclear chromosome segregation GO:1902850 microtubule cytoskeleton organization involved in mitosis |
Molecular Function |
GO:0003774 motor activity GO:0003777 microtubule motor activity GO:0008017 microtubule binding GO:0015631 tubulin binding GO:0016887 ATPase activity |
Cellular Component |
GO:0005769 early endosome GO:0005819 spindle GO:0005871 kinesin complex GO:0005874 microtubule GO:0005875 microtubule associated complex |
KEGG | - |
Reactome |
R-HSA-6811434: COPI-dependent Golgi-to-ER retrograde traffic R-HSA-983231: Factors involved in megakaryocyte development and platelet production R-HSA-8856688: Golgi-to-ER retrograde transport R-HSA-109582: Hemostasis R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-983189: Kinesins R-HSA-199991: Membrane Trafficking R-HSA-5653656: Vesicle-mediated transport |
Summary | |
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Symbol | KIFC1 |
Name | kinesin family member C1 |
Aliases | HSET; KNSL2; kinesin-like 2; kinesin-related protein HSET; Kinesin-like protein KIFC1 |
Chromosomal Location | 6p21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between KIFC1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | KIFC1 |
Name | kinesin family member C1 |
Aliases | HSET; KNSL2; kinesin-like 2; kinesin-related protein HSET; Kinesin-like protein KIFC1 |
Chromosomal Location | 6p21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of KIFC1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | KIFC1 |
Name | kinesin family member C1 |
Aliases | HSET; KNSL2; kinesin-like 2; kinesin-related protein HSET; Kinesin-like protein KIFC1 |
Chromosomal Location | 6p21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of KIFC1 in various data sets.
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Points in the above scatter plot represent the mutation difference of KIFC1 in various data sets.
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Summary | |
---|---|
Symbol | KIFC1 |
Name | kinesin family member C1 |
Aliases | HSET; KNSL2; kinesin-like 2; kinesin-related protein HSET; Kinesin-like protein KIFC1 |
Chromosomal Location | 6p21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KIFC1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | KIFC1 |
Name | kinesin family member C1 |
Aliases | HSET; KNSL2; kinesin-like 2; kinesin-related protein HSET; Kinesin-like protein KIFC1 |
Chromosomal Location | 6p21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KIFC1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KIFC1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | KIFC1 |
Name | kinesin family member C1 |
Aliases | HSET; KNSL2; kinesin-like 2; kinesin-related protein HSET; Kinesin-like protein KIFC1 |
Chromosomal Location | 6p21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KIFC1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | KIFC1 |
Name | kinesin family member C1 |
Aliases | HSET; KNSL2; kinesin-like 2; kinesin-related protein HSET; Kinesin-like protein KIFC1 |
Chromosomal Location | 6p21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of KIFC1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | KIFC1 |
Name | kinesin family member C1 |
Aliases | HSET; KNSL2; kinesin-like 2; kinesin-related protein HSET; Kinesin-like protein KIFC1 |
Chromosomal Location | 6p21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between KIFC1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | KIFC1 |
Name | kinesin family member C1 |
Aliases | HSET; KNSL2; kinesin-like 2; kinesin-related protein HSET; Kinesin-like protein KIFC1 |
Chromosomal Location | 6p21.32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting KIFC1 collected from DrugBank database. |
There is no record. |