Browse KIFC1

Summary
SymbolKIFC1
Namekinesin family member C1
Aliases HSET; KNSL2; kinesin-like 2; kinesin-related protein HSET; Kinesin-like protein KIFC1
Chromosomal Location6p21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle Early endosome Note=Associated with nucleus during interphase, centrosomes in early and spindle in later mitosis.
Domain PF00225 Kinesin motor domain
Function

Minus end-directed microtubule-dependent motor required for bipolar spindle formation (PubMed:15843429). May contribute to movement of early endocytic vesicles (By similarity). Regulates cilium formation and structure (By similarity).

> Gene Ontology
 
Biological Process GO:0000070 mitotic sister chromatid segregation
GO:0000226 microtubule cytoskeleton organization
GO:0000819 sister chromatid segregation
GO:0007018 microtubule-based movement
GO:0007051 spindle organization
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0007080 mitotic metaphase plate congression
GO:0007283 spermatogenesis
GO:0048232 male gamete generation
GO:0050000 chromosome localization
GO:0051225 spindle assembly
GO:0051303 establishment of chromosome localization
GO:0051310 metaphase plate congression
GO:0051640 organelle localization
GO:0051656 establishment of organelle localization
GO:0090307 mitotic spindle assembly
GO:0098813 nuclear chromosome segregation
GO:1902850 microtubule cytoskeleton organization involved in mitosis
Molecular Function GO:0003774 motor activity
GO:0003777 microtubule motor activity
GO:0008017 microtubule binding
GO:0015631 tubulin binding
GO:0016887 ATPase activity
Cellular Component GO:0005769 early endosome
GO:0005819 spindle
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0005875 microtubule associated complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-6811434: COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-983231: Factors involved in megakaryocyte development and platelet production
R-HSA-8856688: Golgi-to-ER retrograde transport
R-HSA-109582: Hemostasis
R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-983189: Kinesins
R-HSA-199991: Membrane Trafficking
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolKIFC1
Namekinesin family member C1
Aliases HSET; KNSL2; kinesin-like 2; kinesin-related protein HSET; Kinesin-like protein KIFC1
Chromosomal Location6p21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between KIFC1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolKIFC1
Namekinesin family member C1
Aliases HSET; KNSL2; kinesin-like 2; kinesin-related protein HSET; Kinesin-like protein KIFC1
Chromosomal Location6p21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of KIFC1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolKIFC1
Namekinesin family member C1
Aliases HSET; KNSL2; kinesin-like 2; kinesin-related protein HSET; Kinesin-like protein KIFC1
Chromosomal Location6p21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of KIFC1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.4030.164
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.4580.454
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.3710.524
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9161.130.0165
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 591.2340.432
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.0020.622
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1730.642
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0590.965
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.5340.699
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.0670.949
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.3840.796
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.5365.84e-05
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of KIFC1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.82.712.10.0439
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.83.411.40.0746
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolKIFC1
Namekinesin family member C1
Aliases HSET; KNSL2; kinesin-like 2; kinesin-related protein HSET; Kinesin-like protein KIFC1
Chromosomal Location6p21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KIFC1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolKIFC1
Namekinesin family member C1
Aliases HSET; KNSL2; kinesin-like 2; kinesin-related protein HSET; Kinesin-like protein KIFC1
Chromosomal Location6p21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KIFC1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KIFC1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolKIFC1
Namekinesin family member C1
Aliases HSET; KNSL2; kinesin-like 2; kinesin-related protein HSET; Kinesin-like protein KIFC1
Chromosomal Location6p21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KIFC1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolKIFC1
Namekinesin family member C1
Aliases HSET; KNSL2; kinesin-like 2; kinesin-related protein HSET; Kinesin-like protein KIFC1
Chromosomal Location6p21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of KIFC1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolKIFC1
Namekinesin family member C1
Aliases HSET; KNSL2; kinesin-like 2; kinesin-related protein HSET; Kinesin-like protein KIFC1
Chromosomal Location6p21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between KIFC1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolKIFC1
Namekinesin family member C1
Aliases HSET; KNSL2; kinesin-like 2; kinesin-related protein HSET; Kinesin-like protein KIFC1
Chromosomal Location6p21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting KIFC1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.