Browse KIT

Summary
SymbolKIT
Namev-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Aliases CD117; SCFR; C-Kit; PBT; piebald trait; p145 c-kit; piebald trait protein; proto-oncogene c-Kit; proto-oncog ......
Chromosomal Location4q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 2: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 3: Cytoplasm. Note=Detected in the cytoplasm of spermatozoa, especially in the equatorial and subacrosomal region of the sperm head.
Domain PF00047 Immunoglobulin domain
PF07714 Protein tyrosine kinase
Function

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.

> Gene Ontology
 
Biological Process GO:0000187 activation of MAPK activity
GO:0001501 skeletal system development
GO:0001541 ovarian follicle development
GO:0001667 ameboidal-type cell migration
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002262 myeloid cell homeostasis
GO:0002263 cell activation involved in immune response
GO:0002274 myeloid leukocyte activation
GO:0002275 myeloid cell activation involved in immune response
GO:0002279 mast cell activation involved in immune response
GO:0002318 myeloid progenitor cell differentiation
GO:0002320 lymphoid progenitor cell differentiation
GO:0002327 immature B cell differentiation
GO:0002366 leukocyte activation involved in immune response
GO:0002367 cytokine production involved in immune response
GO:0002371 dendritic cell cytokine production
GO:0002440 production of molecular mediator of immune response
GO:0002443 leukocyte mediated immunity
GO:0002444 myeloid leukocyte mediated immunity
GO:0002448 mast cell mediated immunity
GO:0002521 leukocyte differentiation
GO:0002551 mast cell chemotaxis
GO:0002573 myeloid leukocyte differentiation
GO:0002764 immune response-regulating signaling pathway
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0006643 membrane lipid metabolic process
GO:0006644 phospholipid metabolic process
GO:0006650 glycerophospholipid metabolic process
GO:0006664 glycolipid metabolic process
GO:0006665 sphingolipid metabolic process
GO:0006687 glycosphingolipid metabolic process
GO:0006887 exocytosis
GO:0007159 leukocyte cell-cell adhesion
GO:0007219 Notch signaling pathway
GO:0007259 JAK-STAT cascade
GO:0007260 tyrosine phosphorylation of STAT protein
GO:0007281 germ cell development
GO:0007283 spermatogenesis
GO:0007286 spermatid development
GO:0007548 sex differentiation
GO:0007605 sensory perception of sound
GO:0007611 learning or memory
GO:0007612 learning
GO:0007632 visual behavior
GO:0008306 associative learning
GO:0008354 germ cell migration
GO:0008360 regulation of cell shape
GO:0008406 gonad development
GO:0008542 visual learning
GO:0008584 male gonad development
GO:0008585 female gonad development
GO:0008593 regulation of Notch signaling pathway
GO:0009314 response to radiation
GO:0009416 response to light stimulus
GO:0009581 detection of external stimulus
GO:0009582 detection of abiotic stimulus
GO:0009612 response to mechanical stimulus
GO:0010517 regulation of phospholipase activity
GO:0010518 positive regulation of phospholipase activity
GO:0010623 programmed cell death involved in cell development
GO:0010631 epithelial cell migration
GO:0010720 positive regulation of cell development
GO:0010863 positive regulation of phospholipase C activity
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0017145 stem cell division
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018212 peptidyl-tyrosine modification
GO:0019216 regulation of lipid metabolic process
GO:0019827 stem cell population maintenance
GO:0022412 cellular process involved in reproduction in multicellular organism
GO:0022602 ovulation cycle process
GO:0022604 regulation of cell morphogenesis
GO:0030031 cell projection assembly
GO:0030032 lamellipodium assembly
GO:0030098 lymphocyte differentiation
GO:0030099 myeloid cell differentiation
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030219 megakaryocyte differentiation
GO:0030258 lipid modification
GO:0030318 melanocyte differentiation
GO:0030335 positive regulation of cell migration
GO:0030595 leukocyte chemotaxis
GO:0031268 pseudopodium organization
GO:0031269 pseudopodium assembly
GO:0031272 regulation of pseudopodium assembly
GO:0031274 positive regulation of pseudopodium assembly
GO:0031346 positive regulation of cell projection organization
GO:0031532 actin cytoskeleton reorganization
GO:0032147 activation of protein kinase activity
GO:0032418 lysosome localization
GO:0032762 mast cell cytokine production
GO:0033674 positive regulation of kinase activity
GO:0034101 erythrocyte homeostasis
GO:0035019 somatic stem cell population maintenance
GO:0035162 embryonic hemopoiesis
GO:0035234 ectopic germ cell programmed cell death
GO:0035701 hematopoietic stem cell migration
GO:0035855 megakaryocyte development
GO:0035886 vascular smooth muscle cell differentiation
GO:0036017 response to erythropoietin
GO:0036018 cellular response to erythropoietin
GO:0036215 response to stem cell factor
GO:0036216 cellular response to stem cell factor stimulus
GO:0038093 Fc receptor signaling pathway
GO:0038109 Kit signaling pathway
GO:0038162 erythropoietin-mediated signaling pathway
GO:0040017 positive regulation of locomotion
GO:0042110 T cell activation
GO:0042113 B cell activation
GO:0042503 tyrosine phosphorylation of Stat3 protein
GO:0042506 tyrosine phosphorylation of Stat5 protein
GO:0042508 tyrosine phosphorylation of Stat1 protein
GO:0042509 regulation of tyrosine phosphorylation of STAT protein
GO:0042510 regulation of tyrosine phosphorylation of Stat1 protein
GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein
GO:0042516 regulation of tyrosine phosphorylation of Stat3 protein
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042522 regulation of tyrosine phosphorylation of Stat5 protein
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042692 muscle cell differentiation
GO:0042698 ovulation cycle
GO:0043299 leukocyte degranulation
GO:0043303 mast cell degranulation
GO:0043405 regulation of MAP kinase activity
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043473 pigmentation
GO:0043550 regulation of lipid kinase activity
GO:0043551 regulation of phosphatidylinositol 3-kinase activity
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0044089 positive regulation of cellular component biogenesis
GO:0044708 single-organism behavior
GO:0045055 regulated exocytosis
GO:0045137 development of primary sexual characteristics
GO:0045576 mast cell activation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045834 positive regulation of lipid metabolic process
GO:0045860 positive regulation of protein kinase activity
GO:0046425 regulation of JAK-STAT cascade
GO:0046427 positive regulation of JAK-STAT cascade
GO:0046486 glycerolipid metabolic process
GO:0046488 phosphatidylinositol metabolic process
GO:0046545 development of primary female sexual characteristics
GO:0046546 development of primary male sexual characteristics
GO:0046660 female sex differentiation
GO:0046661 male sex differentiation
GO:0046777 protein autophosphorylation
GO:0046834 lipid phosphorylation
GO:0046854 phosphatidylinositol phosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048017 inositol lipid-mediated signaling
GO:0048066 developmental pigmentation
GO:0048070 regulation of developmental pigmentation
GO:0048103 somatic stem cell division
GO:0048167 regulation of synaptic plasticity
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048170 positive regulation of long-term neuronal synaptic plasticity
GO:0048232 male gamete generation
GO:0048511 rhythmic process
GO:0048515 spermatid differentiation
GO:0048565 digestive tract development
GO:0048568 embryonic organ development
GO:0048608 reproductive structure development
GO:0048863 stem cell differentiation
GO:0048872 homeostasis of number of cells
GO:0050673 epithelial cell proliferation
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050769 positive regulation of neurogenesis
GO:0050804 modulation of synaptic transmission
GO:0050890 cognition
GO:0050900 leukocyte migration
GO:0050910 detection of mechanical stimulus involved in sensory perception of sound
GO:0050931 pigment cell differentiation
GO:0050954 sensory perception of mechanical stimulus
GO:0050974 detection of mechanical stimulus involved in sensory perception
GO:0050982 detection of mechanical stimulus
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051145 smooth muscle cell differentiation
GO:0051147 regulation of muscle cell differentiation
GO:0051149 positive regulation of muscle cell differentiation
GO:0051150 regulation of smooth muscle cell differentiation
GO:0051152 positive regulation of smooth muscle cell differentiation
GO:0051272 positive regulation of cellular component movement
GO:0051640 organelle localization
GO:0051656 establishment of organelle localization
GO:0051962 positive regulation of nervous system development
GO:0055123 digestive system development
GO:0060191 regulation of lipase activity
GO:0060193 positive regulation of lipase activity
GO:0060326 cell chemotaxis
GO:0060348 bone development
GO:0060374 mast cell differentiation
GO:0060491 regulation of cell projection assembly
GO:0061082 myeloid leukocyte cytokine production
GO:0061458 reproductive system development
GO:0061515 myeloid cell development
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070661 leukocyte proliferation
GO:0070662 mast cell proliferation
GO:0071593 lymphocyte aggregation
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090130 tissue migration
GO:0090132 epithelium migration
GO:0090136 epithelial cell-cell adhesion
GO:0090218 positive regulation of lipid kinase activity
GO:0097066 response to thyroid hormone
GO:0097067 cellular response to thyroid hormone stimulus
GO:0097324 melanocyte migration
GO:0097326 melanocyte adhesion
GO:0097529 myeloid leukocyte migration
GO:0097531 mast cell migration
GO:0097581 lamellipodium organization
GO:0097696 STAT cascade
GO:0098727 maintenance of cell number
GO:0098751 bone cell development
GO:1900274 regulation of phospholipase C activity
GO:1901342 regulation of vasculature development
GO:1903509 liposaccharide metabolic process
GO:1903725 regulation of phospholipid metabolic process
GO:1903727 positive regulation of phospholipid metabolic process
GO:1904018 positive regulation of vasculature development
GO:1904892 regulation of STAT cascade
GO:1904894 positive regulation of STAT cascade
GO:1905063 regulation of vascular smooth muscle cell differentiation
GO:1905065 positive regulation of vascular smooth muscle cell differentiation
GO:2000147 positive regulation of cell motility
Molecular Function GO:0002020 protease binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 receptor signaling protein tyrosine kinase activity
GO:0005020 stem cell factor receptor activity
GO:0005057 receptor signaling protein activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0019199 transmembrane receptor protein kinase activity
GO:0019955 cytokine binding
GO:0035004 phosphatidylinositol 3-kinase activity
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0052813 phosphatidylinositol bisphosphate kinase activity
Cellular Component GO:0001669 acrosomal vesicle
GO:0009897 external side of plasma membrane
GO:0009898 cytoplasmic side of plasma membrane
GO:0030141 secretory granule
GO:0042629 mast cell granule
GO:0097223 sperm part
GO:0098552 side of membrane
GO:0098562 cytoplasmic side of membrane
GO:0099503 secretory vesicle
> KEGG and Reactome Pathway
 
KEGG hsa04014 Ras signaling pathway
hsa04015 Rap1 signaling pathway
hsa04060 Cytokine-cytokine receptor interaction
hsa04144 Endocytosis
hsa04151 PI3K-Akt signaling pathway
hsa04640 Hematopoietic cell lineage
hsa04916 Melanogenesis
Reactome R-HSA-170984: ARMS-mediated activation
R-HSA-1280218: Adaptive Immune System
R-HSA-422475: Axon guidance
R-HSA-2219530: Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-1266738: Developmental Biology
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-186763: Downstream signal transduction
R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR)
R-HSA-2871796: FCERI mediated MAPK activation
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-170968: Frs2-mediated activation
R-HSA-180292: GAB1 signalosome
R-HSA-179812: GRB2 events in EGFR signaling
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-2428924: IGF1R signaling cascade
R-HSA-112399: IRS-mediated signalling
R-HSA-2428928: IRS-related events triggered by IGF1R
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-74751: Insulin receptor signalling cascade
R-HSA-912526: Interleukin receptor SHC signaling
R-HSA-451927: Interleukin-2 signaling
R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling
R-HSA-5683057: MAPK family signaling cascades
R-HSA-5684996: MAPK1/MAPK3 signaling
R-HSA-375165: NCAM signaling for neurite out-growth
R-HSA-187037: NGF signalling via TRKA from the plasma membrane
R-HSA-199418: Negative regulation of the PI3K/AKT network
R-HSA-2219528: PI3K/AKT Signaling in Cancer
R-HSA-198203: PI3K/AKT activation
R-HSA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-1257604: PIP3 activates AKT signaling
R-HSA-169893: Prolonged ERK activation events
R-HSA-5673001: RAF/MAP kinase cascade
R-HSA-8853659: RET signaling
R-HSA-1433559: Regulation of KIT signaling
R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-180336: SHC1 events in EGFR signaling
R-HSA-112412: SOS-mediated signalling
R-HSA-162582: Signal Transduction
R-HSA-177929: Signaling by EGFR
R-HSA-372790: Signaling by GPCR
R-HSA-74752: Signaling by Insulin receptor
R-HSA-449147: Signaling by Interleukins
R-HSA-2586552: Signaling by Leptin
R-HSA-186797: Signaling by PDGF
R-HSA-1433557: Signaling by SCF-KIT
R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-194138: Signaling by VEGF
R-HSA-983705: Signaling by the B Cell Receptor (BCR)
R-HSA-166520: Signalling by NGF
R-HSA-187687: Signalling to ERKs
R-HSA-167044: Signalling to RAS
R-HSA-187706: Signalling to p38 via RIT and RIN
R-HSA-8866910: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-HSA-8864260: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
R-HSA-4420097: VEGFA-VEGFR2 Pathway
R-HSA-5218921: VEGFR2 mediated cell proliferation
Summary
SymbolKIT
Namev-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Aliases CD117; SCFR; C-Kit; PBT; piebald trait; p145 c-kit; piebald trait protein; proto-oncogene c-Kit; proto-oncog ......
Chromosomal Location4q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between KIT and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between KIT and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
27470968Gastrointestinal Stromal TumorInhibit immunity (T cell function); immunotherapy targetPD-1 and PD-L1 blockade in vivo each had no efficacy alone but enhanced the antitumor effects of imatinib by increasing T-cell effector function in the presence of KIT and IDO inhibition.
17885078Colon CarcinomaInhibit immunity (T cell function)More importantly, blockade of SCF receptor (ckit)-SCF interaction by anti-ckit prevented tumor-specific T-cell anergy, Treg development, and tumor angiogenesis. Furthermore, the prevention of MDSC accumulation in conjunction with immune activation therapy showed synergistic therapeutic effect when treating mice bearing large tumors.
16056250Ovarian DysgerminomaInhibit immunityAlthough the prognosis of patients with dysgerminoma is generally good, this receptor could potentially serve as a target for site-specific immunotherapy as an alternative and/or complement to conventional treatment options.
22936666MastocytomaInhibit immunityIn this study, we report that the in vivo antitumor effects of the c-KIT inhibitor, dasatinib, on the c-KIT mutant P815 mastocytoma tumor were substantially dependent on T cell-mediated immunity. We found that dasatinib treatment significantly decreased levels of Tregs while specifically enhancing tumor antigen-specific T-cell responses.
Summary
SymbolKIT
Namev-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Aliases CD117; SCFR; C-Kit; PBT; piebald trait; p145 c-kit; piebald trait protein; proto-oncogene c-Kit; proto-oncog ......
Chromosomal Location4q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of KIT in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolKIT
Namev-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Aliases CD117; SCFR; C-Kit; PBT; piebald trait; p145 c-kit; piebald trait protein; proto-oncogene c-Kit; proto-oncog ......
Chromosomal Location4q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of KIT in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.4750.552
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.8710.564
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2020.884
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.3630.522
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.7480.676
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1130.954
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2680.725
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.3380.442
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.8320.648
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.3490.637
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.7350.411
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.640.00213
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of KIT in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277304.1-4.10.561
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275905.1-5.10.549
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11139.109.10.458
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 6116.7016.71
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolKIT
Namev-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Aliases CD117; SCFR; C-Kit; PBT; piebald trait; p145 c-kit; piebald trait protein; proto-oncogene c-Kit; proto-oncog ......
Chromosomal Location4q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KIT. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolKIT
Namev-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Aliases CD117; SCFR; C-Kit; PBT; piebald trait; p145 c-kit; piebald trait protein; proto-oncogene c-Kit; proto-oncog ......
Chromosomal Location4q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KIT. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KIT.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolKIT
Namev-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Aliases CD117; SCFR; C-Kit; PBT; piebald trait; p145 c-kit; piebald trait protein; proto-oncogene c-Kit; proto-oncog ......
Chromosomal Location4q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KIT. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolKIT
Namev-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Aliases CD117; SCFR; C-Kit; PBT; piebald trait; p145 c-kit; piebald trait protein; proto-oncogene c-Kit; proto-oncog ......
Chromosomal Location4q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of KIT expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolKIT
Namev-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Aliases CD117; SCFR; C-Kit; PBT; piebald trait; p145 c-kit; piebald trait protein; proto-oncogene c-Kit; proto-oncog ......
Chromosomal Location4q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between KIT and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolKIT
Namev-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Aliases CD117; SCFR; C-Kit; PBT; piebald trait; p145 c-kit; piebald trait protein; proto-oncogene c-Kit; proto-oncog ......
Chromosomal Location4q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting KIT collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting KIT.
ID Name Drug Type Targets #Targets
DB00398SorafenibSmall MoleculeBRAF, FGFR1, FLT1, FLT3, FLT4, KDR, KIT, PDGFRB, RAF1, RET10
DB00619ImatinibSmall MoleculeABL1, CSF1R, DDR1, KIT, NTRK1, PDGFRA, PDGFRB7
DB01254DasatinibSmall MoleculeABL1, ABL2, BCR, BTK, CSK, EPHA2, EPHA5, EPHB4, FGR, FRK, FYN, HSP ......22
DB01268SunitinibSmall MoleculeCSF1R, FLT1, FLT3, FLT4, KDR, KIT, PDGFRA, PDGFRB8
DB01962PhosphonotyrosineSmall MoleculeHCK, KIT, SRC3
DB04868NilotinibSmall MoleculeABL1, KIT2
DB05146XL820Small MoleculeKDR, KIT, PDGFRA, PDGFRB4
DB05913OSI-930Small MoleculeFLT1, KIT2
DB06080ABT-869Small MoleculeCSF1R, FLT1, FLT3, FLT4, KDR, KIT6
DB06589PazopanibSmall MoleculeFGF1, FGFR3, FLT1, FLT4, ITK, KDR, KIT, PDGFRA, PDGFRB, SH2B310
DB06595MidostaurinSmall MoleculeFLT3, KDR, KIT, PDGFRA, PDGFRB, PRKCA6
DB08896RegorafenibSmall MoleculeABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, ......18
DB08901PonatinibSmall MoleculeABL1, BCR, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, KDR, KIT, LCK, LYN, P ......15
DB09078LenvatinibSmall MoleculeFGFR1, FGFR2, FGFR3, FGFR4, FLT1, FLT4, KDR, KIT8
DB09103AncestimBiotechKIT1
DB12742AmuvatinibSmall MoleculeFLT3, KIT, MET, PDGFRA, RAD51, RET6