Browse KLF4

Summary
SymbolKLF4
NameKruppel-like factor 4 (gut)
Aliases EZF; GKLF; endothelial Kruppel-like zinc finger protein; epithelial zinc finger protein EZF; gut-enriched kr ......
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus.
Domain -
Function

Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.

> Gene Ontology
 
Biological Process GO:0000302 response to reactive oxygen species
GO:0001101 response to acid chemical
GO:0001525 angiogenesis
GO:0001654 eye development
GO:0001667 ameboidal-type cell migration
GO:0001704 formation of primary germ layer
GO:0001707 mesoderm formation
GO:0001709 cell fate determination
GO:0001710 mesodermal cell fate commitment
GO:0001818 negative regulation of cytokine production
GO:0001933 negative regulation of protein phosphorylation
GO:0002040 sprouting angiogenesis
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0003012 muscle system process
GO:0006644 phospholipid metabolic process
GO:0006809 nitric oxide biosynthetic process
GO:0006979 response to oxidative stress
GO:0007159 leukocyte cell-cell adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007369 gastrulation
GO:0007423 sensory organ development
GO:0007498 mesoderm development
GO:0007500 mesodermal cell fate determination
GO:0008544 epidermis development
GO:0009791 post-embryonic development
GO:0009913 epidermal cell differentiation
GO:0010035 response to inorganic substance
GO:0010466 negative regulation of peptidase activity
GO:0010470 regulation of gastrulation
GO:0010594 regulation of endothelial cell migration
GO:0010596 negative regulation of endothelial cell migration
GO:0010631 epithelial cell migration
GO:0010632 regulation of epithelial cell migration
GO:0010633 negative regulation of epithelial cell migration
GO:0010951 negative regulation of endopeptidase activity
GO:0010975 regulation of neuron projection development
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
GO:0014738 regulation of muscle hyperplasia
GO:0014740 negative regulation of muscle hyperplasia
GO:0014745 negative regulation of muscle adaptation
GO:0014900 muscle hyperplasia
GO:0016055 Wnt signaling pathway
GO:0016525 negative regulation of angiogenesis
GO:0019216 regulation of lipid metabolic process
GO:0019827 stem cell population maintenance
GO:0020027 hemoglobin metabolic process
GO:0022407 regulation of cell-cell adhesion
GO:0022408 negative regulation of cell-cell adhesion
GO:0030336 negative regulation of cell migration
GO:0031077 post-embryonic camera-type eye development
GO:0031099 regeneration
GO:0031102 neuron projection regeneration
GO:0031103 axon regeneration
GO:0031348 negative regulation of defense response
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032102 negative regulation of response to external stimulus
GO:0032526 response to retinoic acid
GO:0032602 chemokine production
GO:0032637 interleukin-8 production
GO:0032642 regulation of chemokine production
GO:0032677 regulation of interleukin-8 production
GO:0032682 negative regulation of chemokine production
GO:0032717 negative regulation of interleukin-8 production
GO:0033002 muscle cell proliferation
GO:0034113 heterotypic cell-cell adhesion
GO:0034114 regulation of heterotypic cell-cell adhesion
GO:0034115 negative regulation of heterotypic cell-cell adhesion
GO:0034405 response to fluid shear stress
GO:0034599 cellular response to oxidative stress
GO:0034614 cellular response to reactive oxygen species
GO:0034616 response to laminar fluid shear stress
GO:0035019 somatic stem cell population maintenance
GO:0035166 post-embryonic hemopoiesis
GO:0040013 negative regulation of locomotion
GO:0042035 regulation of cytokine biosynthetic process
GO:0042036 negative regulation of cytokine biosynthetic process
GO:0042089 cytokine biosynthetic process
GO:0042107 cytokine metabolic process
GO:0042228 interleukin-8 biosynthetic process
GO:0042326 negative regulation of phosphorylation
GO:0042541 hemoglobin biosynthetic process
GO:0042542 response to hydrogen peroxide
GO:0043010 camera-type eye development
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043388 positive regulation of DNA binding
GO:0043409 negative regulation of MAPK cascade
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043491 protein kinase B signaling
GO:0043500 muscle adaptation
GO:0043502 regulation of muscle adaptation
GO:0043534 blood vessel endothelial cell migration
GO:0043535 regulation of blood vessel endothelial cell migration
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0043542 endothelial cell migration
GO:0043550 regulation of lipid kinase activity
GO:0043551 regulation of phosphatidylinositol 3-kinase activity
GO:0044057 regulation of system process
GO:0045165 cell fate commitment
GO:0045414 regulation of interleukin-8 biosynthetic process
GO:0045415 negative regulation of interleukin-8 biosynthetic process
GO:0045428 regulation of nitric oxide biosynthetic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045444 fat cell differentiation
GO:0045765 regulation of angiogenesis
GO:0045861 negative regulation of proteolysis
GO:0045995 regulation of embryonic development
GO:0046209 nitric oxide metabolic process
GO:0046898 response to cycloheximide
GO:0046984 regulation of hemoglobin biosynthetic process
GO:0046985 positive regulation of hemoglobin biosynthetic process
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048017 inositol lipid-mediated signaling
GO:0048332 mesoderm morphogenesis
GO:0048333 mesodermal cell differentiation
GO:0048514 blood vessel morphogenesis
GO:0048569 post-embryonic animal organ development
GO:0048659 smooth muscle cell proliferation
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0048678 response to axon injury
GO:0048679 regulation of axon regeneration
GO:0048730 epidermis morphogenesis
GO:0050727 regulation of inflammatory response
GO:0050728 negative regulation of inflammatory response
GO:0051052 regulation of DNA metabolic process
GO:0051054 positive regulation of DNA metabolic process
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051098 regulation of binding
GO:0051099 positive regulation of binding
GO:0051101 regulation of DNA binding
GO:0051271 negative regulation of cellular component movement
GO:0051346 negative regulation of hydrolase activity
GO:0051896 regulation of protein kinase B signaling
GO:0051898 negative regulation of protein kinase B signaling
GO:0051972 regulation of telomerase activity
GO:0051973 positive regulation of telomerase activity
GO:0052547 regulation of peptidase activity
GO:0052548 regulation of endopeptidase activity
GO:0060070 canonical Wnt signaling pathway
GO:0060759 regulation of response to cytokine stimulus
GO:0060761 negative regulation of response to cytokine stimulus
GO:0060795 cell fate commitment involved in formation of primary germ layer
GO:0061564 axon development
GO:0061756 leukocyte adhesion to vascular endothelial cell
GO:0061757 leukocyte adhesion to arterial endothelial cell
GO:0070301 cellular response to hydrogen peroxide
GO:0070371 ERK1 and ERK2 cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070570 regulation of neuron projection regeneration
GO:0070586 cell-cell adhesion involved in gastrulation
GO:0070587 regulation of cell-cell adhesion involved in gastrulation
GO:0071229 cellular response to acid chemical
GO:0071300 cellular response to retinoic acid
GO:0071396 cellular response to lipid
GO:0071407 cellular response to organic cyclic compound
GO:0071409 cellular response to cycloheximide
GO:0071417 cellular response to organonitrogen compound
GO:0071498 cellular response to fluid shear stress
GO:0071499 cellular response to laminar fluid shear stress
GO:0071897 DNA biosynthetic process
GO:0072567 chemokine (C-X-C motif) ligand 2 production
GO:0072593 reactive oxygen species metabolic process
GO:0090049 regulation of cell migration involved in sprouting angiogenesis
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
GO:0090130 tissue migration
GO:0090132 epithelium migration
GO:0090257 regulation of muscle system process
GO:0097305 response to alcohol
GO:0097306 cellular response to alcohol
GO:0098727 maintenance of cell number
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules
GO:0198738 cell-cell signaling by wnt
GO:1901342 regulation of vasculature development
GO:1901343 negative regulation of vasculature development
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1901654 response to ketone
GO:1901655 cellular response to ketone
GO:1902532 negative regulation of intracellular signal transduction
GO:1903034 regulation of response to wounding
GO:1903037 regulation of leukocyte cell-cell adhesion
GO:1903038 negative regulation of leukocyte cell-cell adhesion
GO:1903409 reactive oxygen species biosynthetic process
GO:1903426 regulation of reactive oxygen species biosynthetic process
GO:1903428 positive regulation of reactive oxygen species biosynthetic process
GO:1903670 regulation of sprouting angiogenesis
GO:1903671 negative regulation of sprouting angiogenesis
GO:1903725 regulation of phospholipid metabolic process
GO:1904407 positive regulation of nitric oxide metabolic process
GO:1904994 regulation of leukocyte adhesion to vascular endothelial cell
GO:1904995 negative regulation of leukocyte adhesion to vascular endothelial cell
GO:1904997 regulation of leukocyte adhesion to arterial endothelial cell
GO:1904998 negative regulation of leukocyte adhesion to arterial endothelial cell
GO:2000116 regulation of cysteine-type endopeptidase activity
GO:2000117 negative regulation of cysteine-type endopeptidase activity
GO:2000146 negative regulation of cell motility
GO:2000181 negative regulation of blood vessel morphogenesis
GO:2000278 regulation of DNA biosynthetic process
GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production
GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000573 positive regulation of DNA biosynthetic process
GO:2000677 regulation of transcription regulatory region DNA binding
GO:2000679 positive regulation of transcription regulatory region DNA binding
GO:2001057 reactive nitrogen species metabolic process
Molecular Function GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting
GO:0001047 core promoter binding
GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001085 RNA polymerase II transcription factor binding
GO:0001134 transcription factor activity, transcription factor recruiting
GO:0001159 core promoter proximal region DNA binding
GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding
GO:0001221 transcription cofactor binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0019207 kinase regulator activity
GO:0035014 phosphatidylinositol 3-kinase regulator activity
GO:0042826 histone deacetylase binding
GO:0098811 transcriptional repressor activity, RNA polymerase II activating transcription factor binding
Cellular Component GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0000791 euchromatin
GO:0005667 transcription factor complex
GO:0005719 nuclear euchromatin
GO:0044454 nuclear chromosome part
GO:0044798 nuclear transcription factor complex
> KEGG and Reactome Pathway
 
KEGG hsa04550 Signaling pathways regulating pluripotency of stem cells
Reactome R-HSA-1266738: Developmental Biology
R-HSA-392499: Metabolism of proteins
R-HSA-2980736: Peptide hormone metabolism
R-HSA-422085: Synthesis, secretion, and deacylation of Ghrelin
R-HSA-452723: Transcriptional regulation of pluripotent stem cells
R-HSA-381340: Transcriptional regulation of white adipocyte differentiation
Summary
SymbolKLF4
NameKruppel-like factor 4 (gut)
Aliases EZF; GKLF; endothelial Kruppel-like zinc finger protein; epithelial zinc finger protein EZF; gut-enriched kr ......
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between KLF4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between KLF4 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
23737434Breast CarcinomaInhibit immunity (T cell function)Finally, we found that CXCL5/CXCR2 axis facilitated MDSC migration and that anti-GM-CSF antibodies neutralized CXCL5-induced accumulation of MDSCs. Taken together, our data suggest that KLF4 modulates maintenance of MDSCs in bone marrow by inducing GM-CSF production via CXCL5 and regulates recruitment of MDSCs into the primary tumors through the CXCL5/CXCR2 axis, both of which contribute to KLF4-mediated mammary tumor development.
28068326MelanomaInhibit immunityKLF4 is regulated by RAS/RAF/MEK/ERK signaling through E2F1 and promotes melanoma cell growth. We find that KLF4 is highly expressed in a subset of human melanomas. Ectopic expression of KLF4 enhances melanoma cell growth by decreasing apoptosis.
Summary
SymbolKLF4
NameKruppel-like factor 4 (gut)
Aliases EZF; GKLF; endothelial Kruppel-like zinc finger protein; epithelial zinc finger protein EZF; gut-enriched kr ......
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of KLF4 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolKLF4
NameKruppel-like factor 4 (gut)
Aliases EZF; GKLF; endothelial Kruppel-like zinc finger protein; epithelial zinc finger protein EZF; gut-enriched kr ......
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of KLF4 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2670.566
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1480.927
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.5960.501
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.4240.545
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.7830.724
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.0260.993
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0570.904
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.3610.763
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.5210.692
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.0970.303
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.8110.221
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.170.263
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of KLF4 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.112.5-1.41
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59022.2-22.20.505
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolKLF4
NameKruppel-like factor 4 (gut)
Aliases EZF; GKLF; endothelial Kruppel-like zinc finger protein; epithelial zinc finger protein EZF; gut-enriched kr ......
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KLF4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolKLF4
NameKruppel-like factor 4 (gut)
Aliases EZF; GKLF; endothelial Kruppel-like zinc finger protein; epithelial zinc finger protein EZF; gut-enriched kr ......
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KLF4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KLF4.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolKLF4
NameKruppel-like factor 4 (gut)
Aliases EZF; GKLF; endothelial Kruppel-like zinc finger protein; epithelial zinc finger protein EZF; gut-enriched kr ......
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KLF4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolKLF4
NameKruppel-like factor 4 (gut)
Aliases EZF; GKLF; endothelial Kruppel-like zinc finger protein; epithelial zinc finger protein EZF; gut-enriched kr ......
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of KLF4 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolKLF4
NameKruppel-like factor 4 (gut)
Aliases EZF; GKLF; endothelial Kruppel-like zinc finger protein; epithelial zinc finger protein EZF; gut-enriched kr ......
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between KLF4 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolKLF4
NameKruppel-like factor 4 (gut)
Aliases EZF; GKLF; endothelial Kruppel-like zinc finger protein; epithelial zinc finger protein EZF; gut-enriched kr ......
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting KLF4 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.