Summary | |
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Symbol | KLHL17 |
Name | kelch-like family member 17 |
Aliases | actinfilin; kelch-like 17 (Drosophila); kelch-like 17; Kelch-like protein 17 |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell junction, synapse, postsynaptic cell membrane, postsynaptic density Cell junction, synapse Note=Postsynaptic density. |
Domain |
PF07707 BTB And C-terminal Kelch PF00651 BTB/POZ domain PF01344 Kelch motif |
Function |
Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity). |
Biological Process | - |
Molecular Function |
GO:0003779 actin binding GO:0004842 ubiquitin-protein transferase activity GO:0019787 ubiquitin-like protein transferase activity GO:0031208 POZ domain binding GO:0032947 protein complex scaffold GO:0051015 actin filament binding |
Cellular Component |
GO:0000151 ubiquitin ligase complex GO:0014069 postsynaptic density GO:0015629 actin cytoskeleton GO:0030425 dendrite GO:0031461 cullin-RING ubiquitin ligase complex GO:0031463 Cul3-RING ubiquitin ligase complex GO:0032838 cell projection cytoplasm GO:0032839 dendrite cytoplasm GO:0043025 neuronal cell body GO:0044297 cell body GO:0045211 postsynaptic membrane GO:0060076 excitatory synapse GO:0097060 synaptic membrane GO:0098794 postsynapse GO:0099568 cytoplasmic region GO:0099572 postsynaptic specialization |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | KLHL17 |
Name | kelch-like family member 17 |
Aliases | actinfilin; kelch-like 17 (Drosophila); kelch-like 17; Kelch-like protein 17 |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between KLHL17 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | KLHL17 |
Name | kelch-like family member 17 |
Aliases | actinfilin; kelch-like 17 (Drosophila); kelch-like 17; Kelch-like protein 17 |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of KLHL17 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | KLHL17 |
Name | kelch-like family member 17 |
Aliases | actinfilin; kelch-like 17 (Drosophila); kelch-like 17; Kelch-like protein 17 |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of KLHL17 in various data sets.
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Points in the above scatter plot represent the mutation difference of KLHL17 in various data sets.
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Summary | |
---|---|
Symbol | KLHL17 |
Name | kelch-like family member 17 |
Aliases | actinfilin; kelch-like 17 (Drosophila); kelch-like 17; Kelch-like protein 17 |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KLHL17. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | KLHL17 |
Name | kelch-like family member 17 |
Aliases | actinfilin; kelch-like 17 (Drosophila); kelch-like 17; Kelch-like protein 17 |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KLHL17. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KLHL17. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | KLHL17 |
Name | kelch-like family member 17 |
Aliases | actinfilin; kelch-like 17 (Drosophila); kelch-like 17; Kelch-like protein 17 |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KLHL17. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | KLHL17 |
Name | kelch-like family member 17 |
Aliases | actinfilin; kelch-like 17 (Drosophila); kelch-like 17; Kelch-like protein 17 |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of KLHL17 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | KLHL17 |
Name | kelch-like family member 17 |
Aliases | actinfilin; kelch-like 17 (Drosophila); kelch-like 17; Kelch-like protein 17 |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between KLHL17 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | KLHL17 |
Name | kelch-like family member 17 |
Aliases | actinfilin; kelch-like 17 (Drosophila); kelch-like 17; Kelch-like protein 17 |
Chromosomal Location | 1p36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting KLHL17 collected from DrugBank database. |
There is no record. |