Summary | |
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Symbol | KLKB1 |
Name | kallikrein B, plasma (Fletcher factor) 1 |
Aliases | PKKD; Fletcher factor; kininogenin; plasma kallikrein heavy chain; plasma kallikrein light chain; plasma pre ...... |
Chromosomal Location | 4q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00024 PAN domain PF00089 Trypsin |
Function |
The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. |
Biological Process |
GO:0002254 kinin cascade GO:0002353 plasma kallikrein-kinin cascade GO:0002526 acute inflammatory response GO:0002541 activation of plasma proteins involved in acute inflammatory response GO:0002542 Factor XII activation GO:0002673 regulation of acute inflammatory response GO:0002675 positive regulation of acute inflammatory response GO:0007596 blood coagulation GO:0007597 blood coagulation, intrinsic pathway GO:0007599 hemostasis GO:0010954 positive regulation of protein processing GO:0016485 protein processing GO:0022617 extracellular matrix disassembly GO:0030193 regulation of blood coagulation GO:0030195 negative regulation of blood coagulation GO:0030198 extracellular matrix organization GO:0031349 positive regulation of defense response GO:0031638 zymogen activation GO:0031639 plasminogen activation GO:0032102 negative regulation of response to external stimulus GO:0032103 positive regulation of response to external stimulus GO:0042730 fibrinolysis GO:0043062 extracellular structure organization GO:0045862 positive regulation of proteolysis GO:0050727 regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0050817 coagulation GO:0050818 regulation of coagulation GO:0050819 negative regulation of coagulation GO:0050878 regulation of body fluid levels GO:0051604 protein maturation GO:0051917 regulation of fibrinolysis GO:0051919 positive regulation of fibrinolysis GO:0061041 regulation of wound healing GO:0061045 negative regulation of wound healing GO:0070613 regulation of protein processing GO:0072376 protein activation cascade GO:0072378 blood coagulation, fibrin clot formation GO:1900046 regulation of hemostasis GO:1900047 negative regulation of hemostasis GO:1903034 regulation of response to wounding GO:1903035 negative regulation of response to wounding GO:1903317 regulation of protein maturation GO:1903319 positive regulation of protein maturation |
Molecular Function |
GO:0004175 endopeptidase activity GO:0004252 serine-type endopeptidase activity GO:0008236 serine-type peptidase activity GO:0017171 serine hydrolase activity |
Cellular Component | - |
KEGG |
hsa04610 Complement and coagulation cascades |
Reactome |
R-HSA-1592389: Activation of Matrix Metalloproteinases R-HSA-1474228: Degradation of the extracellular matrix R-HSA-1474244: Extracellular matrix organization R-HSA-140877: Formation of Fibrin Clot (Clotting Cascade) R-HSA-109582: Hemostasis R-HSA-140837: Intrinsic Pathway of Fibrin Clot Formation |
Summary | |
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Symbol | KLKB1 |
Name | kallikrein B, plasma (Fletcher factor) 1 |
Aliases | PKKD; Fletcher factor; kininogenin; plasma kallikrein heavy chain; plasma kallikrein light chain; plasma pre ...... |
Chromosomal Location | 4q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between KLKB1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | KLKB1 |
Name | kallikrein B, plasma (Fletcher factor) 1 |
Aliases | PKKD; Fletcher factor; kininogenin; plasma kallikrein heavy chain; plasma kallikrein light chain; plasma pre ...... |
Chromosomal Location | 4q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of KLKB1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | KLKB1 |
Name | kallikrein B, plasma (Fletcher factor) 1 |
Aliases | PKKD; Fletcher factor; kininogenin; plasma kallikrein heavy chain; plasma kallikrein light chain; plasma pre ...... |
Chromosomal Location | 4q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of KLKB1 in various data sets.
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Points in the above scatter plot represent the mutation difference of KLKB1 in various data sets.
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Summary | |
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Symbol | KLKB1 |
Name | kallikrein B, plasma (Fletcher factor) 1 |
Aliases | PKKD; Fletcher factor; kininogenin; plasma kallikrein heavy chain; plasma kallikrein light chain; plasma pre ...... |
Chromosomal Location | 4q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KLKB1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | KLKB1 |
Name | kallikrein B, plasma (Fletcher factor) 1 |
Aliases | PKKD; Fletcher factor; kininogenin; plasma kallikrein heavy chain; plasma kallikrein light chain; plasma pre ...... |
Chromosomal Location | 4q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KLKB1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KLKB1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | KLKB1 |
Name | kallikrein B, plasma (Fletcher factor) 1 |
Aliases | PKKD; Fletcher factor; kininogenin; plasma kallikrein heavy chain; plasma kallikrein light chain; plasma pre ...... |
Chromosomal Location | 4q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KLKB1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | KLKB1 |
Name | kallikrein B, plasma (Fletcher factor) 1 |
Aliases | PKKD; Fletcher factor; kininogenin; plasma kallikrein heavy chain; plasma kallikrein light chain; plasma pre ...... |
Chromosomal Location | 4q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of KLKB1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | KLKB1 |
Name | kallikrein B, plasma (Fletcher factor) 1 |
Aliases | PKKD; Fletcher factor; kininogenin; plasma kallikrein heavy chain; plasma kallikrein light chain; plasma pre ...... |
Chromosomal Location | 4q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between KLKB1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | KLKB1 |
Name | kallikrein B, plasma (Fletcher factor) 1 |
Aliases | PKKD; Fletcher factor; kininogenin; plasma kallikrein heavy chain; plasma kallikrein light chain; plasma pre ...... |
Chromosomal Location | 4q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting KLKB1 collected from DrugBank database. |
Details on drugs targeting KLKB1.
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