Browse KLKB1

Summary
SymbolKLKB1
Namekallikrein B, plasma (Fletcher factor) 1
Aliases PKKD; Fletcher factor; kininogenin; plasma kallikrein heavy chain; plasma kallikrein light chain; plasma pre ......
Chromosomal Location4q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted.
Domain PF00024 PAN domain
PF00089 Trypsin
Function

The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.

> Gene Ontology
 
Biological Process GO:0002254 kinin cascade
GO:0002353 plasma kallikrein-kinin cascade
GO:0002526 acute inflammatory response
GO:0002541 activation of plasma proteins involved in acute inflammatory response
GO:0002542 Factor XII activation
GO:0002673 regulation of acute inflammatory response
GO:0002675 positive regulation of acute inflammatory response
GO:0007596 blood coagulation
GO:0007597 blood coagulation, intrinsic pathway
GO:0007599 hemostasis
GO:0010954 positive regulation of protein processing
GO:0016485 protein processing
GO:0022617 extracellular matrix disassembly
GO:0030193 regulation of blood coagulation
GO:0030195 negative regulation of blood coagulation
GO:0030198 extracellular matrix organization
GO:0031349 positive regulation of defense response
GO:0031638 zymogen activation
GO:0031639 plasminogen activation
GO:0032102 negative regulation of response to external stimulus
GO:0032103 positive regulation of response to external stimulus
GO:0042730 fibrinolysis
GO:0043062 extracellular structure organization
GO:0045862 positive regulation of proteolysis
GO:0050727 regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0050817 coagulation
GO:0050818 regulation of coagulation
GO:0050819 negative regulation of coagulation
GO:0050878 regulation of body fluid levels
GO:0051604 protein maturation
GO:0051917 regulation of fibrinolysis
GO:0051919 positive regulation of fibrinolysis
GO:0061041 regulation of wound healing
GO:0061045 negative regulation of wound healing
GO:0070613 regulation of protein processing
GO:0072376 protein activation cascade
GO:0072378 blood coagulation, fibrin clot formation
GO:1900046 regulation of hemostasis
GO:1900047 negative regulation of hemostasis
GO:1903034 regulation of response to wounding
GO:1903035 negative regulation of response to wounding
GO:1903317 regulation of protein maturation
GO:1903319 positive regulation of protein maturation
Molecular Function GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0017171 serine hydrolase activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04610 Complement and coagulation cascades
Reactome R-HSA-1592389: Activation of Matrix Metalloproteinases
R-HSA-1474228: Degradation of the extracellular matrix
R-HSA-1474244: Extracellular matrix organization
R-HSA-140877: Formation of Fibrin Clot (Clotting Cascade)
R-HSA-109582: Hemostasis
R-HSA-140837: Intrinsic Pathway of Fibrin Clot Formation
Summary
SymbolKLKB1
Namekallikrein B, plasma (Fletcher factor) 1
Aliases PKKD; Fletcher factor; kininogenin; plasma kallikrein heavy chain; plasma kallikrein light chain; plasma pre ......
Chromosomal Location4q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between KLKB1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolKLKB1
Namekallikrein B, plasma (Fletcher factor) 1
Aliases PKKD; Fletcher factor; kininogenin; plasma kallikrein heavy chain; plasma kallikrein light chain; plasma pre ......
Chromosomal Location4q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of KLKB1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolKLKB1
Namekallikrein B, plasma (Fletcher factor) 1
Aliases PKKD; Fletcher factor; kininogenin; plasma kallikrein heavy chain; plasma kallikrein light chain; plasma pre ......
Chromosomal Location4q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of KLKB1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.4320.359
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.3360.664
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.9970.124
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.5930.262
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.3830.182
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3890.71
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3680.623
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2040.851
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.7390.504
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.0410.975
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.0080.543
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1930.356
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of KLKB1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.82.712.10.0439
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.83.411.40.0746
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.311.82.51
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86250250.473
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.718.2-10.50.576
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382710.57.43.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221313.67.75.91
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.27.1-0.91
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolKLKB1
Namekallikrein B, plasma (Fletcher factor) 1
Aliases PKKD; Fletcher factor; kininogenin; plasma kallikrein heavy chain; plasma kallikrein light chain; plasma pre ......
Chromosomal Location4q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KLKB1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolKLKB1
Namekallikrein B, plasma (Fletcher factor) 1
Aliases PKKD; Fletcher factor; kininogenin; plasma kallikrein heavy chain; plasma kallikrein light chain; plasma pre ......
Chromosomal Location4q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KLKB1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KLKB1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolKLKB1
Namekallikrein B, plasma (Fletcher factor) 1
Aliases PKKD; Fletcher factor; kininogenin; plasma kallikrein heavy chain; plasma kallikrein light chain; plasma pre ......
Chromosomal Location4q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KLKB1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolKLKB1
Namekallikrein B, plasma (Fletcher factor) 1
Aliases PKKD; Fletcher factor; kininogenin; plasma kallikrein heavy chain; plasma kallikrein light chain; plasma pre ......
Chromosomal Location4q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of KLKB1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolKLKB1
Namekallikrein B, plasma (Fletcher factor) 1
Aliases PKKD; Fletcher factor; kininogenin; plasma kallikrein heavy chain; plasma kallikrein light chain; plasma pre ......
Chromosomal Location4q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between KLKB1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolKLKB1
Namekallikrein B, plasma (Fletcher factor) 1
Aliases PKKD; Fletcher factor; kininogenin; plasma kallikrein heavy chain; plasma kallikrein light chain; plasma pre ......
Chromosomal Location4q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting KLKB1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting KLKB1.
ID Name Drug Type Targets #Targets
DB01593ZincSmall MoleculeA1BG, A2M, AGT, AHSG, ALDOA, APCS, APLP1, APLP2, APOA1, APOA2, APO ......119
DB05311EcallantideBiotechKLKB11
DB06404Human C1-esterase inhibitorBiotechC1R, C1S, F11, F12, F2, KLKB1, PLAT7
DB09228Conestat alfaBiotechC1R, C1S, F11, F12, F2, KLKB1, PLAT7
DB12831GabexateSmall MoleculeF2, KLKB1, PLG3