Summary | |
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Symbol | KLRC4 |
Name | killer cell lectin-like receptor subfamily C, member 4 |
Aliases | NKG2-F; NKG2F; NK cell receptor F; NKG2-F-activating NK receptor; natual killer cell group 2-F; NKG2-F type ...... |
Chromosomal Location | 12p13.2-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Single-pass type II membrane protein. |
Domain | - |
Function |
May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells. |
Biological Process |
GO:0006968 cellular defense response |
Molecular Function | - |
Cellular Component | - |
KEGG |
hsa04612 Antigen processing and presentation |
Reactome | - |
Summary | |
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Symbol | KLRC4 |
Name | killer cell lectin-like receptor subfamily C, member 4 |
Aliases | NKG2-F; NKG2F; NK cell receptor F; NKG2-F-activating NK receptor; natual killer cell group 2-F; NKG2-F type ...... |
Chromosomal Location | 12p13.2-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between KLRC4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | KLRC4 |
Name | killer cell lectin-like receptor subfamily C, member 4 |
Aliases | NKG2-F; NKG2F; NK cell receptor F; NKG2-F-activating NK receptor; natual killer cell group 2-F; NKG2-F type ...... |
Chromosomal Location | 12p13.2-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of KLRC4 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | KLRC4 |
Name | killer cell lectin-like receptor subfamily C, member 4 |
Aliases | NKG2-F; NKG2F; NK cell receptor F; NKG2-F-activating NK receptor; natual killer cell group 2-F; NKG2-F type ...... |
Chromosomal Location | 12p13.2-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of KLRC4 in various data sets.
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Points in the above scatter plot represent the mutation difference of KLRC4 in various data sets.
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Summary | |
---|---|
Symbol | KLRC4 |
Name | killer cell lectin-like receptor subfamily C, member 4 |
Aliases | NKG2-F; NKG2F; NK cell receptor F; NKG2-F-activating NK receptor; natual killer cell group 2-F; NKG2-F type ...... |
Chromosomal Location | 12p13.2-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KLRC4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | KLRC4 |
Name | killer cell lectin-like receptor subfamily C, member 4 |
Aliases | NKG2-F; NKG2F; NK cell receptor F; NKG2-F-activating NK receptor; natual killer cell group 2-F; NKG2-F type ...... |
Chromosomal Location | 12p13.2-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KLRC4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KLRC4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | KLRC4 |
Name | killer cell lectin-like receptor subfamily C, member 4 |
Aliases | NKG2-F; NKG2F; NK cell receptor F; NKG2-F-activating NK receptor; natual killer cell group 2-F; NKG2-F type ...... |
Chromosomal Location | 12p13.2-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KLRC4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | KLRC4 |
Name | killer cell lectin-like receptor subfamily C, member 4 |
Aliases | NKG2-F; NKG2F; NK cell receptor F; NKG2-F-activating NK receptor; natual killer cell group 2-F; NKG2-F type ...... |
Chromosomal Location | 12p13.2-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of KLRC4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | KLRC4 |
Name | killer cell lectin-like receptor subfamily C, member 4 |
Aliases | NKG2-F; NKG2F; NK cell receptor F; NKG2-F-activating NK receptor; natual killer cell group 2-F; NKG2-F type ...... |
Chromosomal Location | 12p13.2-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between KLRC4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | KLRC4 |
Name | killer cell lectin-like receptor subfamily C, member 4 |
Aliases | NKG2-F; NKG2F; NK cell receptor F; NKG2-F-activating NK receptor; natual killer cell group 2-F; NKG2-F type ...... |
Chromosomal Location | 12p13.2-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting KLRC4 collected from DrugBank database. |
There is no record. |