Summary | |
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Symbol | KLRK1 |
Name | killer cell lectin-like receptor subfamily K, member 1 |
Aliases | NKG2D; KLR; NKG2-D; CD314; D12S2489E; DNA segment on chromosome 12 (unique) 2489 expressed sequence; CD anti ...... |
Chromosomal Location | 12p13.2-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type II membrane protein Note=Colocalized with HCST on the cell surface. |
Domain |
PF00059 Lectin C-type domain |
Function |
Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. |
Biological Process |
GO:0001819 positive regulation of cytokine production GO:0001906 cell killing GO:0001909 leukocyte mediated cytotoxicity GO:0001910 regulation of leukocyte mediated cytotoxicity GO:0001912 positive regulation of leukocyte mediated cytotoxicity GO:0002218 activation of innate immune response GO:0002220 innate immune response activating cell surface receptor signaling pathway GO:0002223 stimulatory C-type lectin receptor signaling pathway GO:0002228 natural killer cell mediated immunity GO:0002237 response to molecule of bacterial origin GO:0002250 adaptive immune response GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002683 negative regulation of immune system process GO:0002685 regulation of leukocyte migration GO:0002686 negative regulation of leukocyte migration GO:0002688 regulation of leukocyte chemotaxis GO:0002689 negative regulation of leukocyte chemotaxis GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002703 regulation of leukocyte mediated immunity GO:0002705 positive regulation of leukocyte mediated immunity GO:0002706 regulation of lymphocyte mediated immunity GO:0002708 positive regulation of lymphocyte mediated immunity GO:0002715 regulation of natural killer cell mediated immunity GO:0002717 positive regulation of natural killer cell mediated immunity GO:0002757 immune response-activating signal transduction GO:0002758 innate immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0006809 nitric oxide biosynthetic process GO:0007159 leukocyte cell-cell adhesion GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030101 natural killer cell activation GO:0030336 negative regulation of cell migration GO:0030595 leukocyte chemotaxis GO:0031294 lymphocyte costimulation GO:0031295 T cell costimulation GO:0031341 regulation of cell killing GO:0031343 positive regulation of cell killing GO:0031349 positive regulation of defense response GO:0032102 negative regulation of response to external stimulus GO:0032496 response to lipopolysaccharide GO:0032609 interferon-gamma production GO:0032649 regulation of interferon-gamma production GO:0032729 positive regulation of interferon-gamma production GO:0034260 negative regulation of GTPase activity GO:0035747 natural killer cell chemotaxis GO:0040013 negative regulation of locomotion GO:0042110 T cell activation GO:0042267 natural killer cell mediated cytotoxicity GO:0042269 regulation of natural killer cell mediated cytotoxicity GO:0042742 defense response to bacterium GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045428 regulation of nitric oxide biosynthetic process GO:0045429 positive regulation of nitric oxide biosynthetic process GO:0045785 positive regulation of cell adhesion GO:0045954 positive regulation of natural killer cell mediated cytotoxicity GO:0046209 nitric oxide metabolic process GO:0048247 lymphocyte chemotaxis GO:0050830 defense response to Gram-positive bacterium GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0050900 leukocyte migration GO:0050920 regulation of chemotaxis GO:0050922 negative regulation of chemotaxis GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051271 negative regulation of cellular component movement GO:0051346 negative regulation of hydrolase activity GO:0060326 cell chemotaxis GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071396 cellular response to lipid GO:0071593 lymphocyte aggregation GO:0072593 reactive oxygen species metabolic process GO:0072676 lymphocyte migration GO:0098542 defense response to other organism GO:1901623 regulation of lymphocyte chemotaxis GO:1901624 negative regulation of lymphocyte chemotaxis GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903409 reactive oxygen species biosynthetic process GO:1903426 regulation of reactive oxygen species biosynthetic process GO:1903428 positive regulation of reactive oxygen species biosynthetic process GO:1904407 positive regulation of nitric oxide metabolic process GO:2000146 negative regulation of cell motility GO:2000377 regulation of reactive oxygen species metabolic process GO:2000379 positive regulation of reactive oxygen species metabolic process GO:2000401 regulation of lymphocyte migration GO:2000402 negative regulation of lymphocyte migration GO:2000501 regulation of natural killer cell chemotaxis GO:2000502 negative regulation of natural killer cell chemotaxis GO:2001057 reactive nitrogen species metabolic process |
Molecular Function |
GO:0030246 carbohydrate binding GO:0032394 MHC class Ib receptor activity GO:0042287 MHC protein binding GO:0042288 MHC class I protein binding |
Cellular Component |
GO:0009897 external side of plasma membrane GO:0098552 side of membrane |
KEGG |
hsa04650 Natural killer cell mediated cytotoxicity |
Reactome |
R-HSA-1280218: Adaptive Immune System R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-168256: Immune System R-HSA-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-168249: Innate Immune System |
Summary | |
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Symbol | KLRK1 |
Name | killer cell lectin-like receptor subfamily K, member 1 |
Aliases | NKG2D; KLR; NKG2-D; CD314; D12S2489E; DNA segment on chromosome 12 (unique) 2489 expressed sequence; CD anti ...... |
Chromosomal Location | 12p13.2-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between KLRK1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between KLRK1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | KLRK1 |
Name | killer cell lectin-like receptor subfamily K, member 1 |
Aliases | NKG2D; KLR; NKG2-D; CD314; D12S2489E; DNA segment on chromosome 12 (unique) 2489 expressed sequence; CD anti ...... |
Chromosomal Location | 12p13.2-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of KLRK1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | KLRK1 |
Name | killer cell lectin-like receptor subfamily K, member 1 |
Aliases | NKG2D; KLR; NKG2-D; CD314; D12S2489E; DNA segment on chromosome 12 (unique) 2489 expressed sequence; CD anti ...... |
Chromosomal Location | 12p13.2-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of KLRK1 in various data sets.
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Points in the above scatter plot represent the mutation difference of KLRK1 in various data sets.
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Summary | |
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Symbol | KLRK1 |
Name | killer cell lectin-like receptor subfamily K, member 1 |
Aliases | NKG2D; KLR; NKG2-D; CD314; D12S2489E; DNA segment on chromosome 12 (unique) 2489 expressed sequence; CD anti ...... |
Chromosomal Location | 12p13.2-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KLRK1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | KLRK1 |
Name | killer cell lectin-like receptor subfamily K, member 1 |
Aliases | NKG2D; KLR; NKG2-D; CD314; D12S2489E; DNA segment on chromosome 12 (unique) 2489 expressed sequence; CD anti ...... |
Chromosomal Location | 12p13.2-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KLRK1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KLRK1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | KLRK1 |
Name | killer cell lectin-like receptor subfamily K, member 1 |
Aliases | NKG2D; KLR; NKG2-D; CD314; D12S2489E; DNA segment on chromosome 12 (unique) 2489 expressed sequence; CD anti ...... |
Chromosomal Location | 12p13.2-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KLRK1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | KLRK1 |
Name | killer cell lectin-like receptor subfamily K, member 1 |
Aliases | NKG2D; KLR; NKG2-D; CD314; D12S2489E; DNA segment on chromosome 12 (unique) 2489 expressed sequence; CD anti ...... |
Chromosomal Location | 12p13.2-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of KLRK1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | KLRK1 |
Name | killer cell lectin-like receptor subfamily K, member 1 |
Aliases | NKG2D; KLR; NKG2-D; CD314; D12S2489E; DNA segment on chromosome 12 (unique) 2489 expressed sequence; CD anti ...... |
Chromosomal Location | 12p13.2-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between KLRK1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | KLRK1 |
Name | killer cell lectin-like receptor subfamily K, member 1 |
Aliases | NKG2D; KLR; NKG2-D; CD314; D12S2489E; DNA segment on chromosome 12 (unique) 2489 expressed sequence; CD anti ...... |
Chromosomal Location | 12p13.2-p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting KLRK1 collected from DrugBank database. |
There is no record. |