Summary | |
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Symbol | KMT2B |
Name | lysine (K)-specific methyltransferase 2B |
Aliases | KIAA0304; HRX2; WBP7; MLL1B; CXXC10; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophi ...... |
Chromosomal Location | 19q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF05965 F/Y rich C-terminus PF05964 F/Y-rich N-terminus PF00628 PHD-finger PF00856 SET domain PF02008 CXXC zinc finger domain |
Function |
Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development. Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation. |
Biological Process |
GO:0001541 ovarian follicle development GO:0006338 chromatin remodeling GO:0006479 protein methylation GO:0007281 germ cell development GO:0007292 female gamete generation GO:0007548 sex differentiation GO:0007611 learning or memory GO:0007613 memory GO:0008213 protein alkylation GO:0008406 gonad development GO:0008585 female gonad development GO:0009994 oocyte differentiation GO:0016458 gene silencing GO:0016570 histone modification GO:0016571 histone methylation GO:0018022 peptidyl-lysine methylation GO:0018023 peptidyl-lysine trimethylation GO:0018205 peptidyl-lysine modification GO:0022412 cellular process involved in reproduction in multicellular organism GO:0022602 ovulation cycle process GO:0030728 ovulation GO:0031056 regulation of histone modification GO:0031060 regulation of histone methylation GO:0032259 methylation GO:0034968 histone lysine methylation GO:0040029 regulation of gene expression, epigenetic GO:0042698 ovulation cycle GO:0043414 macromolecule methylation GO:0044708 single-organism behavior GO:0045137 development of primary sexual characteristics GO:0045815 positive regulation of gene expression, epigenetic GO:0046545 development of primary female sexual characteristics GO:0046660 female sex differentiation GO:0048096 chromatin-mediated maintenance of transcription GO:0048477 oogenesis GO:0048511 rhythmic process GO:0048608 reproductive structure development GO:0050890 cognition GO:0051568 histone H3-K4 methylation GO:0051569 regulation of histone H3-K4 methylation GO:0061458 reproductive system development GO:0080182 histone H3-K4 trimethylation GO:1902275 regulation of chromatin organization |
Molecular Function |
GO:0008168 methyltransferase activity GO:0008170 N-methyltransferase activity GO:0008276 protein methyltransferase activity GO:0008757 S-adenosylmethionine-dependent methyltransferase activity GO:0016278 lysine N-methyltransferase activity GO:0016279 protein-lysine N-methyltransferase activity GO:0016741 transferase activity, transferring one-carbon groups GO:0018024 histone-lysine N-methyltransferase activity GO:0042054 histone methyltransferase activity GO:0042800 histone methyltransferase activity (H3-K4 specific) |
Cellular Component |
GO:0034708 methyltransferase complex GO:0035097 histone methyltransferase complex |
KEGG |
hsa00310 Lysine degradation |
Reactome |
R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-3214841: PKMTs methylate histone lysines |
Summary | |
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Symbol | KMT2B |
Name | lysine (K)-specific methyltransferase 2B |
Aliases | KIAA0304; HRX2; WBP7; MLL1B; CXXC10; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophi ...... |
Chromosomal Location | 19q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between KMT2B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | KMT2B |
Name | lysine (K)-specific methyltransferase 2B |
Aliases | KIAA0304; HRX2; WBP7; MLL1B; CXXC10; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophi ...... |
Chromosomal Location | 19q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of KMT2B in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | KMT2B |
Name | lysine (K)-specific methyltransferase 2B |
Aliases | KIAA0304; HRX2; WBP7; MLL1B; CXXC10; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophi ...... |
Chromosomal Location | 19q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of KMT2B in various data sets.
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Points in the above scatter plot represent the mutation difference of KMT2B in various data sets.
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Summary | |
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Symbol | KMT2B |
Name | lysine (K)-specific methyltransferase 2B |
Aliases | KIAA0304; HRX2; WBP7; MLL1B; CXXC10; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophi ...... |
Chromosomal Location | 19q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KMT2B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | KMT2B |
Name | lysine (K)-specific methyltransferase 2B |
Aliases | KIAA0304; HRX2; WBP7; MLL1B; CXXC10; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophi ...... |
Chromosomal Location | 19q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KMT2B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KMT2B. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | KMT2B |
Name | lysine (K)-specific methyltransferase 2B |
Aliases | KIAA0304; HRX2; WBP7; MLL1B; CXXC10; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophi ...... |
Chromosomal Location | 19q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KMT2B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | KMT2B |
Name | lysine (K)-specific methyltransferase 2B |
Aliases | KIAA0304; HRX2; WBP7; MLL1B; CXXC10; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophi ...... |
Chromosomal Location | 19q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of KMT2B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | KMT2B |
Name | lysine (K)-specific methyltransferase 2B |
Aliases | KIAA0304; HRX2; WBP7; MLL1B; CXXC10; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophi ...... |
Chromosomal Location | 19q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between KMT2B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | KMT2B |
Name | lysine (K)-specific methyltransferase 2B |
Aliases | KIAA0304; HRX2; WBP7; MLL1B; CXXC10; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophi ...... |
Chromosomal Location | 19q13.12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting KMT2B collected from DrugBank database. |
There is no record. |