Summary | |
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Symbol | KMT2C |
Name | lysine (K)-specific methyltransferase 2C |
Aliases | KIAA1506; HALR; MLL3; myeloid/lymphoid or mixed-lineage leukemia 3; ALR-like protein; histone-lysine N-methy ...... |
Chromosomal Location | 7q36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF05965 F/Y rich C-terminus PF05964 F/Y-rich N-terminus PF00628 PHD-finger PF00856 SET domain |
Function |
Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder. |
Biological Process |
GO:0006479 protein methylation GO:0008213 protein alkylation GO:0016570 histone modification GO:0016571 histone methylation GO:0018022 peptidyl-lysine methylation GO:0018205 peptidyl-lysine modification GO:0032259 methylation GO:0034968 histone lysine methylation GO:0043414 macromolecule methylation GO:0051568 histone H3-K4 methylation |
Molecular Function |
GO:0008168 methyltransferase activity GO:0008170 N-methyltransferase activity GO:0008276 protein methyltransferase activity GO:0008757 S-adenosylmethionine-dependent methyltransferase activity GO:0016278 lysine N-methyltransferase activity GO:0016279 protein-lysine N-methyltransferase activity GO:0016741 transferase activity, transferring one-carbon groups GO:0016746 transferase activity, transferring acyl groups GO:0018024 histone-lysine N-methyltransferase activity GO:0042054 histone methyltransferase activity GO:0042800 histone methyltransferase activity (H3-K4 specific) |
Cellular Component |
GO:0034708 methyltransferase complex GO:0035097 histone methyltransferase complex GO:0044666 MLL3/4 complex |
KEGG |
hsa00310 Lysine degradation |
Reactome |
R-HSA-5619507: Activation of HOX genes during differentiation R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-1266738: Developmental Biology R-HSA-3214841: PKMTs methylate histone lysines |
Summary | |
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Symbol | KMT2C |
Name | lysine (K)-specific methyltransferase 2C |
Aliases | KIAA1506; HALR; MLL3; myeloid/lymphoid or mixed-lineage leukemia 3; ALR-like protein; histone-lysine N-methy ...... |
Chromosomal Location | 7q36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between KMT2C and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | KMT2C |
Name | lysine (K)-specific methyltransferase 2C |
Aliases | KIAA1506; HALR; MLL3; myeloid/lymphoid or mixed-lineage leukemia 3; ALR-like protein; histone-lysine N-methy ...... |
Chromosomal Location | 7q36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of KMT2C in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | KMT2C |
Name | lysine (K)-specific methyltransferase 2C |
Aliases | KIAA1506; HALR; MLL3; myeloid/lymphoid or mixed-lineage leukemia 3; ALR-like protein; histone-lysine N-methy ...... |
Chromosomal Location | 7q36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of KMT2C in various data sets.
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Points in the above scatter plot represent the mutation difference of KMT2C in various data sets.
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Summary | |
---|---|
Symbol | KMT2C |
Name | lysine (K)-specific methyltransferase 2C |
Aliases | KIAA1506; HALR; MLL3; myeloid/lymphoid or mixed-lineage leukemia 3; ALR-like protein; histone-lysine N-methy ...... |
Chromosomal Location | 7q36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KMT2C. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | KMT2C |
Name | lysine (K)-specific methyltransferase 2C |
Aliases | KIAA1506; HALR; MLL3; myeloid/lymphoid or mixed-lineage leukemia 3; ALR-like protein; histone-lysine N-methy ...... |
Chromosomal Location | 7q36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KMT2C. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KMT2C. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | KMT2C |
Name | lysine (K)-specific methyltransferase 2C |
Aliases | KIAA1506; HALR; MLL3; myeloid/lymphoid or mixed-lineage leukemia 3; ALR-like protein; histone-lysine N-methy ...... |
Chromosomal Location | 7q36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KMT2C. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | KMT2C |
Name | lysine (K)-specific methyltransferase 2C |
Aliases | KIAA1506; HALR; MLL3; myeloid/lymphoid or mixed-lineage leukemia 3; ALR-like protein; histone-lysine N-methy ...... |
Chromosomal Location | 7q36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of KMT2C expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | KMT2C |
Name | lysine (K)-specific methyltransferase 2C |
Aliases | KIAA1506; HALR; MLL3; myeloid/lymphoid or mixed-lineage leukemia 3; ALR-like protein; histone-lysine N-methy ...... |
Chromosomal Location | 7q36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between KMT2C and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | KMT2C |
Name | lysine (K)-specific methyltransferase 2C |
Aliases | KIAA1506; HALR; MLL3; myeloid/lymphoid or mixed-lineage leukemia 3; ALR-like protein; histone-lysine N-methy ...... |
Chromosomal Location | 7q36 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting KMT2C collected from DrugBank database. |
There is no record. |