Browse KRAS

Summary
SymbolKRAS
NameKirsten rat sarcoma viral oncogene homolog
Aliases KRAS1; KRAS2; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma viral on ......
Chromosomal Location12p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Lipid-anchor Cytoplasmic side Cytoplasm, cytosol
Domain PF00071 Ras family
Function

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306).

> Gene Ontology
 
Biological Process GO:0001763 morphogenesis of a branching structure
GO:0001889 liver development
GO:0001894 tissue homeostasis
GO:0002218 activation of innate immune response
GO:0002220 innate immune response activating cell surface receptor signaling pathway
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002429 immune response-activating cell surface receptor signaling pathway
GO:0002757 immune response-activating signal transduction
GO:0002758 innate immune response-activating signal transduction
GO:0002764 immune response-regulating signaling pathway
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007270 neuron-neuron synaptic transmission
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007568 aging
GO:0007569 cell aging
GO:0007611 learning or memory
GO:0007612 learning
GO:0007632 visual behavior
GO:0008306 associative learning
GO:0008542 visual learning
GO:0009314 response to radiation
GO:0009416 response to light stimulus
GO:0010001 glial cell differentiation
GO:0014002 astrocyte development
GO:0016601 Rac protein signal transduction
GO:0021782 glial cell development
GO:0021896 forebrain astrocyte differentiation
GO:0021897 forebrain astrocyte development
GO:0030323 respiratory tube development
GO:0030324 lung development
GO:0030900 forebrain development
GO:0031349 positive regulation of defense response
GO:0031647 regulation of protein stability
GO:0031960 response to corticosteroid
GO:0032228 regulation of synaptic transmission, GABAergic
GO:0032768 regulation of monooxygenase activity
GO:0032770 positive regulation of monooxygenase activity
GO:0033674 positive regulation of kinase activity
GO:0035020 regulation of Rac protein signal transduction
GO:0035022 positive regulation of Rac protein signal transduction
GO:0035176 social behavior
GO:0035239 tube morphogenesis
GO:0038002 endocrine signaling
GO:0038093 Fc receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038127 ERBB signaling pathway
GO:0038128 ERBB2 signaling pathway
GO:0042063 gliogenesis
GO:0042692 muscle cell differentiation
GO:0043405 regulation of MAP kinase activity
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0044708 single-organism behavior
GO:0045088 regulation of innate immune response
GO:0045089 positive regulation of innate immune response
GO:0045860 positive regulation of protein kinase activity
GO:0046578 regulation of Ras protein signal transduction
GO:0046579 positive regulation of Ras protein signal transduction
GO:0048167 regulation of synaptic plasticity
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048545 response to steroid hormone
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048708 astrocyte differentiation
GO:0048732 gland development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048871 multicellular organismal homeostasis
GO:0048872 homeostasis of number of cells
GO:0048873 homeostasis of number of cells within a tissue
GO:0050804 modulation of synaptic transmission
GO:0050886 endocrine process
GO:0050890 cognition
GO:0050900 leukocyte migration
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051057 positive regulation of small GTPase mediated signal transduction
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051146 striated muscle cell differentiation
GO:0051341 regulation of oxidoreductase activity
GO:0051353 positive regulation of oxidoreductase activity
GO:0051384 response to glucocorticoid
GO:0051385 response to mineralocorticoid
GO:0051402 neuron apoptotic process
GO:0051703 intraspecies interaction between organisms
GO:0051705 multi-organism behavior
GO:0051932 synaptic transmission, GABAergic
GO:0060249 anatomical structure homeostasis
GO:0060425 lung morphogenesis
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060541 respiratory system development
GO:0060562 epithelial tube morphogenesis
GO:0061008 hepaticobiliary system development
GO:0061138 morphogenesis of a branching epithelium
GO:0061564 axon development
GO:0070997 neuron death
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090342 regulation of cell aging
GO:0090343 positive regulation of cell aging
GO:0090398 cellular senescence
GO:0097485 neuron projection guidance
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:2000772 regulation of cellular senescence
GO:2000774 positive regulation of cellular senescence
Molecular Function GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0019002 GMP binding
GO:0019003 GDP binding
GO:0030275 LRR domain binding
GO:0032561 guanyl ribonucleotide binding
Cellular Component GO:0005924 cell-substrate adherens junction
GO:0005925 focal adhesion
GO:0009898 cytoplasmic side of plasma membrane
GO:0019897 extrinsic component of plasma membrane
GO:0019898 extrinsic component of membrane
GO:0030055 cell-substrate junction
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0045121 membrane raft
GO:0098552 side of membrane
GO:0098562 cytoplasmic side of membrane
GO:0098589 membrane region
GO:0098857 membrane microdomain
> KEGG and Reactome Pathway
 
KEGG hsa04010 MAPK signaling pathway
hsa04012 ErbB signaling pathway
hsa04014 Ras signaling pathway
hsa04015 Rap1 signaling pathway
hsa04062 Chemokine signaling pathway
hsa04068 FoxO signaling pathway
hsa04071 Sphingolipid signaling pathway
hsa04140 Regulation of autophagy
hsa04150 mTOR signaling pathway
hsa04151 PI3K-Akt signaling pathway
hsa04210 Apoptosis
hsa04320 Dorso-ventral axis formation
hsa04360 Axon guidance
hsa04370 VEGF signaling pathway
hsa04540 Gap junction
hsa04550 Signaling pathways regulating pluripotency of stem cells
hsa04650 Natural killer cell mediated cytotoxicity
hsa04660 T cell receptor signaling pathway
hsa04662 B cell receptor signaling pathway
hsa04664 Fc epsilon RI signaling pathway
hsa04720 Long-term potentiation
hsa04722 Neurotrophin signaling pathway
hsa04725 Cholinergic synapse
hsa04726 Serotonergic synapse
hsa04730 Long-term depression
hsa04810 Regulation of actin cytoskeleton
hsa04910 Insulin signaling pathway
hsa04912 GnRH signaling pathway
hsa04914 Progesterone-mediated oocyte maturation
hsa04915 Estrogen signaling pathway
hsa04916 Melanogenesis
hsa04917 Prolactin signaling pathway
hsa04919 Thyroid hormone signaling pathway
hsa04921 Oxytocin signaling pathway
hsa04960 Aldosterone-regulated sodium reabsorption
Reactome R-HSA-170984: ARMS-mediated activation
R-HSA-1169092: Activation of RAS in B cells
R-HSA-1280218: Adaptive Immune System
R-HSA-422475: Axon guidance
R-HSA-5621481: C-type lectin receptors (CLRs)
R-HSA-5621575: CD209 (DC-SIGN) signaling
R-HSA-202733: Cell surface interactions at the vascular wall
R-HSA-5637810: Constitutive Signaling by EGFRvIII
R-HSA-1236382: Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-1266738: Developmental Biology
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-186763: Downstream signal transduction
R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR)
R-HSA-5654687: Downstream signaling of activated FGFR1
R-HSA-5654696: Downstream signaling of activated FGFR2
R-HSA-5654708: Downstream signaling of activated FGFR3
R-HSA-5654716: Downstream signaling of activated FGFR4
R-HSA-2179392: EGFR Transactivation by Gastrin
R-HSA-2871796: FCERI mediated MAPK activation
R-HSA-5654693: FRS-mediated FGFR1 signaling
R-HSA-5654700: FRS-mediated FGFR2 signaling
R-HSA-5654706: FRS-mediated FGFR3 signaling
R-HSA-5654712: FRS-mediated FGFR4 signaling
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-170968: Frs2-mediated activation
R-HSA-179812: GRB2 events in EGFR signaling
R-HSA-1963640: GRB2 events in ERBB2 signaling
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-109582: Hemostasis
R-HSA-2428924: IGF1R signaling cascade
R-HSA-112399: IRS-mediated signalling
R-HSA-2428928: IRS-related events triggered by IGF1R
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-74751: Insulin receptor signalling cascade
R-HSA-912526: Interleukin receptor SHC signaling
R-HSA-451927: Interleukin-2 signaling
R-HSA-512988: Interleukin-3, 5 and GM-CSF signaling
R-HSA-5674135: MAP2K and MAPK activation
R-HSA-5683057: MAPK family signaling cascades
R-HSA-5684996: MAPK1/MAPK3 signaling
R-HSA-8851805: MET activates RAS signaling
R-HSA-375165: NCAM signaling for neurite out-growth
R-HSA-187037: NGF signalling via TRKA from the plasma membrane
R-HSA-5675221: Negative regulation of MAPK pathway
R-HSA-6802957: Oncogenic MAPK signaling
R-HSA-8849471: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-HSA-6802955: Paradoxical activation of RAF signaling by kinase inactive BRAF
R-HSA-169893: Prolonged ERK activation events
R-HSA-5673000: RAF activation
R-HSA-5673001: RAF/MAP kinase cascade
R-HSA-6802953: RAS signaling downstream of NF1 loss-of-function variants
R-HSA-8853659: RET signaling
R-HSA-5658442: Regulation of RAS by GAPs
R-HSA-5654688: SHC-mediated cascade
R-HSA-5654699: SHC-mediated cascade
R-HSA-5654704: SHC-mediated cascade
R-HSA-5654719: SHC-mediated cascade
R-HSA-2428933: SHC-related events triggered by IGF1R
R-HSA-180336: SHC1 events in EGFR signaling
R-HSA-1250196: SHC1 events in ERBB2 signaling
R-HSA-1250347: SHC1 events in ERBB4 signaling
R-HSA-112412: SOS-mediated signalling
R-HSA-162582: Signal Transduction
R-HSA-6802952: Signaling by BRAF and RAF fusions
R-HSA-177929: Signaling by EGFR
R-HSA-1643713: Signaling by EGFR in Cancer
R-HSA-5637812: Signaling by EGFRvIII in Cancer
R-HSA-1227986: Signaling by ERBB2
R-HSA-1236394: Signaling by ERBB4
R-HSA-190236: Signaling by FGFR
R-HSA-1226099: Signaling by FGFR in disease
R-HSA-5654736: Signaling by FGFR1
R-HSA-5655302: Signaling by FGFR1 in disease
R-HSA-5654738: Signaling by FGFR2
R-HSA-5655253: Signaling by FGFR2 in disease
R-HSA-5654741: Signaling by FGFR3
R-HSA-8853334: Signaling by FGFR3 fusions in cancer
R-HSA-5655332: Signaling by FGFR3 in disease
R-HSA-8853338: Signaling by FGFR3 point mutants in cancer
R-HSA-5654743: Signaling by FGFR4
R-HSA-5655291: Signaling by FGFR4 in disease
R-HSA-372790: Signaling by GPCR
R-HSA-74752: Signaling by Insulin receptor
R-HSA-449147: Signaling by Interleukins
R-HSA-2586552: Signaling by Leptin
R-HSA-5637815: Signaling by Ligand-Responsive EGFR Variants in Cancer
R-HSA-6806834: Signaling by MET
R-HSA-186797: Signaling by PDGF
R-HSA-8848021: Signaling by PTK6
R-HSA-6802949: Signaling by RAS mutants
R-HSA-1433557: Signaling by SCF-KIT
R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-194138: Signaling by VEGF
R-HSA-6802948: Signaling by high-kinase activity BRAF mutants
R-HSA-6802946: Signaling by moderate kinase activity BRAF mutants
R-HSA-983705: Signaling by the B Cell Receptor (BCR)
R-HSA-166520: Signalling by NGF
R-HSA-187687: Signalling to ERKs
R-HSA-167044: Signalling to RAS
R-HSA-187706: Signalling to p38 via RIT and RIN
R-HSA-210993: Tie2 Signaling
R-HSA-4420097: VEGFA-VEGFR2 Pathway
R-HSA-5218921: VEGFR2 mediated cell proliferation
R-HSA-171007: p38MAPK events
Summary
SymbolKRAS
NameKirsten rat sarcoma viral oncogene homolog
Aliases KRAS1; KRAS2; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma viral on ......
Chromosomal Location12p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between KRAS and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between KRAS and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
26880715Lung CarcinomaInhibit immunity (T cell function)Overexpression of the mutant KRAS(G12V)gene in wild-type KRAS tumor cells led to regulatory T-cell (Treg) induction. We also demonstrate that mutant KRAS induces the secretion of IL10 and transforming growth factor-β1 (both required for Treg induction) by tumor cells through the activation of the MEK-ERK-AP1 pathway.
26872698lung adenocarcinomaInhibit immunity (infiltration)Here, using lung adenocarcinoma mouse models, including genetic models, we show that autochthonous tumors that lacked T cell infiltration and resisted current treatment options could be successfully sensitized to host antitumor T cell immunity when appropriately selected immunogenic drugs (e.g., oxaliplatin combined with cyclophosphamide for treatment against tumors expressing oncogenic Kras and lacking Trp53) were used.
24607504Pancreatic NeoplasmInhibit immunity (T cell function); immunotherapy targetThe combination of LM-Kras and Treg cell depletion reduced numbers of Foxp3(+)CD4(+) T cells in pancreatic lymph nodes, increased numbers of CD4(+) T cells that secrete interleukin 17 and interferon γ, and caused CD11b(+)Gr1(+) cells in the pancreas to acquire an immunostimulatory phenotype.
18025475Actinic (Solar) Keratosis; Skin Basal Cell Carcinoma; Squamous Cell CarcinomaInhibit immunity (T cell function)Here we demonstrate that human keratinocyte-derived skin tumors may evade T cell-mediated antitumor immune responses by down-regulating the expression of CCL27 through the activation of epidermal growth factor receptor (EGFR)-Ras-MAPK-signaling pathways. Compared with healthy skin, CCL27 mRNA and protein expression was progressively lost in transformed keratinocytes of actinic keratoses and basal and squamous cell carcinomas.
29604293Pancreatic ductal adenocarcinoma; melanoma; colon carcinomaInhibit immunityWe performed studies with Mist1Cre;LSLKras;Rosa26mTmG (KCiMist;G) and Kras(G12D);Trp53(R172H);Pdx1-Cre (KPC) mice (which upon tamoxifen induction spontaneously develop PanINs) and control littermates.
29587865Adenocarcinoma of the Mouse Pulmonary System; colorectal adenocarcinomaInhibit immunityThe primary PEACs harbor a high incidence of KRAS mutation but almost absent of EGFR mutation.
24276238Non-Small Cell Lung CarcinomaInhibit immunityScrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo. We show that loss of Scrib and activated oncogenic KRas cooperate in vivo, resulting in more aggressive lung tumors, likely due to a synergistic elevation in RAS-MAPK signaling.
Summary
SymbolKRAS
NameKirsten rat sarcoma viral oncogene homolog
Aliases KRAS1; KRAS2; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma viral on ......
Chromosomal Location12p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of KRAS in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolKRAS
NameKirsten rat sarcoma viral oncogene homolog
Aliases KRAS1; KRAS2; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma viral on ......
Chromosomal Location12p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of KRAS in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0340.899
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.2270.883
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1030.924
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.3340.313
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.4320.762
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.210.907
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.130.74
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0370.983
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.3030.869
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.3470.722
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.8490.564
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1030.183
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of KRAS in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 1417505.944.10.0109
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103700700.0699
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.72.711
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.73.40.31
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382707.4-7.40.169
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 2213015.4-15.40.131
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolKRAS
NameKirsten rat sarcoma viral oncogene homolog
Aliases KRAS1; KRAS2; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma viral on ......
Chromosomal Location12p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KRAS. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolKRAS
NameKirsten rat sarcoma viral oncogene homolog
Aliases KRAS1; KRAS2; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma viral on ......
Chromosomal Location12p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KRAS. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KRAS.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolKRAS
NameKirsten rat sarcoma viral oncogene homolog
Aliases KRAS1; KRAS2; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma viral on ......
Chromosomal Location12p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KRAS. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolKRAS
NameKirsten rat sarcoma viral oncogene homolog
Aliases KRAS1; KRAS2; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma viral on ......
Chromosomal Location12p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of KRAS expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolKRAS
NameKirsten rat sarcoma viral oncogene homolog
Aliases KRAS1; KRAS2; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma viral on ......
Chromosomal Location12p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between KRAS and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolKRAS
NameKirsten rat sarcoma viral oncogene homolog
Aliases KRAS1; KRAS2; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma viral on ......
Chromosomal Location12p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting KRAS collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting KRAS.
ID Name Drug Type Targets #Targets
DB07771[(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACIDSmall MoleculeFNTA, FNTB, KRAS3
DB07780FARNESYL DIPHOSPHATESmall MoleculeFDPS, FNTA, FNTB, GGPS1, KRAS, RABGGTA, RABGGTB7