Summary | |
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Symbol | KRT4 |
Name | keratin 4, type II |
Aliases | CK4; K4; cytokeratin 4; keratin, type II cytoskeletal 4; keratin 4; CK-4; WSN1; type-II keratin Kb4; Keratin ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF00038 Intermediate filament protein PF16208 Keratin type II head |
Function |
- |
Biological Process |
GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050680 negative regulation of epithelial cell proliferation |
Molecular Function | - |
Cellular Component |
GO:0005882 intermediate filament GO:0045095 keratin filament GO:0045111 intermediate filament cytoskeleton |
KEGG | - |
Reactome |
R-HSA-1266738: Developmental Biology R-HSA-6805567: Keratinization |
Summary | |
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Symbol | KRT4 |
Name | keratin 4, type II |
Aliases | CK4; K4; cytokeratin 4; keratin, type II cytoskeletal 4; keratin 4; CK-4; WSN1; type-II keratin Kb4; Keratin ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between KRT4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | KRT4 |
Name | keratin 4, type II |
Aliases | CK4; K4; cytokeratin 4; keratin, type II cytoskeletal 4; keratin 4; CK-4; WSN1; type-II keratin Kb4; Keratin ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of KRT4 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | KRT4 |
Name | keratin 4, type II |
Aliases | CK4; K4; cytokeratin 4; keratin, type II cytoskeletal 4; keratin 4; CK-4; WSN1; type-II keratin Kb4; Keratin ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of KRT4 in various data sets.
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Points in the above scatter plot represent the mutation difference of KRT4 in various data sets.
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Summary | |
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Symbol | KRT4 |
Name | keratin 4, type II |
Aliases | CK4; K4; cytokeratin 4; keratin, type II cytoskeletal 4; keratin 4; CK-4; WSN1; type-II keratin Kb4; Keratin ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KRT4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | KRT4 |
Name | keratin 4, type II |
Aliases | CK4; K4; cytokeratin 4; keratin, type II cytoskeletal 4; keratin 4; CK-4; WSN1; type-II keratin Kb4; Keratin ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KRT4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KRT4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | KRT4 |
Name | keratin 4, type II |
Aliases | CK4; K4; cytokeratin 4; keratin, type II cytoskeletal 4; keratin 4; CK-4; WSN1; type-II keratin Kb4; Keratin ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KRT4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | KRT4 |
Name | keratin 4, type II |
Aliases | CK4; K4; cytokeratin 4; keratin, type II cytoskeletal 4; keratin 4; CK-4; WSN1; type-II keratin Kb4; Keratin ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of KRT4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | KRT4 |
Name | keratin 4, type II |
Aliases | CK4; K4; cytokeratin 4; keratin, type II cytoskeletal 4; keratin 4; CK-4; WSN1; type-II keratin Kb4; Keratin ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between KRT4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | KRT4 |
Name | keratin 4, type II |
Aliases | CK4; K4; cytokeratin 4; keratin, type II cytoskeletal 4; keratin 4; CK-4; WSN1; type-II keratin Kb4; Keratin ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting KRT4 collected from DrugBank database. |
There is no record. |