Summary | |
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Symbol | KRT8 |
Name | keratin 8, type II |
Aliases | CK8; CYK8; K2C8; KO; keratin 8; CK-8; cytokeratin 8; cytokeratin-8; type-II keratin Kb8; Keratin-8; Keratin, ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus, nucleoplasm Nucleus matrix |
Domain |
PF00038 Intermediate filament protein PF16208 Keratin type II head |
Function |
Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. |
Biological Process |
GO:0001101 response to acid chemical GO:0001701 in utero embryonic development GO:0001890 placenta development GO:0001892 embryonic placenta development GO:0009415 response to water GO:0010035 response to inorganic substance GO:0010927 cellular component assembly involved in morphogenesis GO:0030239 myofibril assembly GO:0031032 actomyosin structure organization GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0034612 response to tumor necrosis factor GO:0042692 muscle cell differentiation GO:0045214 sarcomere organization GO:0048568 embryonic organ development GO:0048608 reproductive structure development GO:0051146 striated muscle cell differentiation GO:0051599 response to hydrostatic pressure GO:0055001 muscle cell development GO:0055002 striated muscle cell development GO:0060706 cell differentiation involved in embryonic placenta development GO:0061458 reproductive system development GO:0071356 cellular response to tumor necrosis factor GO:0097191 extrinsic apoptotic signaling pathway GO:0097284 hepatocyte apoptotic process GO:1904019 epithelial cell apoptotic process |
Molecular Function |
GO:0097110 scaffold protein binding |
Cellular Component |
GO:0005882 intermediate filament GO:0016010 dystrophin-associated glycoprotein complex GO:0016363 nuclear matrix GO:0030016 myofibril GO:0030017 sarcomere GO:0030018 Z disc GO:0031674 I band GO:0034399 nuclear periphery GO:0042383 sarcolemma GO:0043034 costamere GO:0043292 contractile fiber GO:0044449 contractile fiber part GO:0045095 keratin filament GO:0045111 intermediate filament cytoskeleton GO:0090665 glycoprotein complex |
KEGG | - |
Reactome |
R-HSA-1266738: Developmental Biology R-HSA-6805567: Keratinization |
Summary | |
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Symbol | KRT8 |
Name | keratin 8, type II |
Aliases | CK8; CYK8; K2C8; KO; keratin 8; CK-8; cytokeratin 8; cytokeratin-8; type-II keratin Kb8; Keratin-8; Keratin, ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between KRT8 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | KRT8 |
Name | keratin 8, type II |
Aliases | CK8; CYK8; K2C8; KO; keratin 8; CK-8; cytokeratin 8; cytokeratin-8; type-II keratin Kb8; Keratin-8; Keratin, ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of KRT8 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | KRT8 |
Name | keratin 8, type II |
Aliases | CK8; CYK8; K2C8; KO; keratin 8; CK-8; cytokeratin 8; cytokeratin-8; type-II keratin Kb8; Keratin-8; Keratin, ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of KRT8 in various data sets.
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Points in the above scatter plot represent the mutation difference of KRT8 in various data sets.
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Summary | |
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Symbol | KRT8 |
Name | keratin 8, type II |
Aliases | CK8; CYK8; K2C8; KO; keratin 8; CK-8; cytokeratin 8; cytokeratin-8; type-II keratin Kb8; Keratin-8; Keratin, ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KRT8. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | KRT8 |
Name | keratin 8, type II |
Aliases | CK8; CYK8; K2C8; KO; keratin 8; CK-8; cytokeratin 8; cytokeratin-8; type-II keratin Kb8; Keratin-8; Keratin, ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KRT8. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KRT8. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | KRT8 |
Name | keratin 8, type II |
Aliases | CK8; CYK8; K2C8; KO; keratin 8; CK-8; cytokeratin 8; cytokeratin-8; type-II keratin Kb8; Keratin-8; Keratin, ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KRT8. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | KRT8 |
Name | keratin 8, type II |
Aliases | CK8; CYK8; K2C8; KO; keratin 8; CK-8; cytokeratin 8; cytokeratin-8; type-II keratin Kb8; Keratin-8; Keratin, ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of KRT8 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | KRT8 |
Name | keratin 8, type II |
Aliases | CK8; CYK8; K2C8; KO; keratin 8; CK-8; cytokeratin 8; cytokeratin-8; type-II keratin Kb8; Keratin-8; Keratin, ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between KRT8 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | KRT8 |
Name | keratin 8, type II |
Aliases | CK8; CYK8; K2C8; KO; keratin 8; CK-8; cytokeratin 8; cytokeratin-8; type-II keratin Kb8; Keratin-8; Keratin, ...... |
Chromosomal Location | 12q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting KRT8 collected from DrugBank database. |
Details on drugs targeting KRT8.
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