| Summary | |
|---|---|
| Symbol | KRTAP4-12 |
| Name | keratin associated protein 4-12 |
| Aliases | KAP4.12; KRTAP4.12; keratin-associated protein 4.12; ultrahigh sulfur keratin-associated protein 4.12; Kerat ...... |
| Chromosomal Location | 17q21.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
| Subcellular Location | - |
| Domain |
PF13885 Keratin |
| Function |
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. |
| Biological Process | - |
| Molecular Function | - |
| Cellular Component |
GO:0005882 intermediate filament GO:0045095 keratin filament GO:0045111 intermediate filament cytoskeleton |
| KEGG | - |
| Reactome | - |
| Summary | |
|---|---|
| Symbol | KRTAP4-12 |
| Name | keratin associated protein 4-12 |
| Aliases | KAP4.12; KRTAP4.12; keratin-associated protein 4.12; ultrahigh sulfur keratin-associated protein 4.12; Kerat ...... |
| Chromosomal Location | 17q21.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content | Literatures that report relations between KRTAP4-12 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
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There is no record. |
| Summary | |
|---|---|
| Symbol | KRTAP4-12 |
| Name | keratin associated protein 4-12 |
| Aliases | KAP4.12; KRTAP4.12; keratin-associated protein 4.12; ultrahigh sulfur keratin-associated protein 4.12; Kerat ...... |
| Chromosomal Location | 17q21.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
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> High-throughput Screening
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Statistical results of KRTAP4-12 in screening data sets for detecting immune reponses.
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| Summary | |
|---|---|
| Symbol | KRTAP4-12 |
| Name | keratin associated protein 4-12 |
| Aliases | KAP4.12; KRTAP4.12; keratin-associated protein 4.12; ultrahigh sulfur keratin-associated protein 4.12; Kerat ...... |
| Chromosomal Location | 17q21.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
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Points in the above scatter plot represent the expression difference of KRTAP4-12 in various data sets.
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There is no record. |
| Summary | |
|---|---|
| Symbol | KRTAP4-12 |
| Name | keratin associated protein 4-12 |
| Aliases | KAP4.12; KRTAP4.12; keratin-associated protein 4.12; ultrahigh sulfur keratin-associated protein 4.12; Kerat ...... |
| Chromosomal Location | 17q21.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KRTAP4-12. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
| Summary | |
|---|---|
| Symbol | KRTAP4-12 |
| Name | keratin associated protein 4-12 |
| Aliases | KAP4.12; KRTAP4.12; keratin-associated protein 4.12; ultrahigh sulfur keratin-associated protein 4.12; Kerat ...... |
| Chromosomal Location | 17q21.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KRTAP4-12. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KRTAP4-12. > Immunoinhibitor > Immunostimulator > MHC molecule |
| Summary | |
|---|---|
| Symbol | KRTAP4-12 |
| Name | keratin associated protein 4-12 |
| Aliases | KAP4.12; KRTAP4.12; keratin-associated protein 4.12; ultrahigh sulfur keratin-associated protein 4.12; Kerat ...... |
| Chromosomal Location | 17q21.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KRTAP4-12. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
| Summary | |
|---|---|
| Symbol | KRTAP4-12 |
| Name | keratin associated protein 4-12 |
| Aliases | KAP4.12; KRTAP4.12; keratin-associated protein 4.12; ultrahigh sulfur keratin-associated protein 4.12; Kerat ...... |
| Chromosomal Location | 17q21.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Distribution of KRTAP4-12 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
| Summary | |
|---|---|
| Symbol | KRTAP4-12 |
| Name | keratin associated protein 4-12 |
| Aliases | KAP4.12; KRTAP4.12; keratin-associated protein 4.12; ultrahigh sulfur keratin-associated protein 4.12; Kerat ...... |
| Chromosomal Location | 17q21.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Associations between KRTAP4-12 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
| Summary | |
|---|---|
| Symbol | KRTAP4-12 |
| Name | keratin associated protein 4-12 |
| Aliases | KAP4.12; KRTAP4.12; keratin-associated protein 4.12; ultrahigh sulfur keratin-associated protein 4.12; Kerat ...... |
| Chromosomal Location | 17q21.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content | Drugs targeting KRTAP4-12 collected from DrugBank database. |
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There is no record. |