Summary | |
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Symbol | LAMA3 |
Name | laminin, alpha 3 |
Aliases | nicein-150kDa; kalinin-165kDa; BM600-150kDa; epiligrin; LAMNA; laminin, alpha 3 (nicein (150kD), kalinin (16 ...... |
Chromosomal Location | 18q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component. |
Domain |
PF00052 Laminin B (Domain IV) PF00053 Laminin EGF domain PF02210 Laminin G domain PF06008 Laminin Domain I PF06009 Laminin Domain II PF00055 Laminin N-terminal (Domain VI) |
Function |
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.; FUNCTION: Laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-FAK and p80, (3) differentiation of keratinocytes. |
Biological Process |
GO:0001704 formation of primary germ layer GO:0001706 endoderm formation GO:0007044 cell-substrate junction assembly GO:0007369 gastrulation GO:0007492 endoderm development GO:0008544 epidermis development GO:0022617 extracellular matrix disassembly GO:0030198 extracellular matrix organization GO:0031581 hemidesmosome assembly GO:0034329 cell junction assembly GO:0034330 cell junction organization GO:0035987 endodermal cell differentiation GO:0043062 extracellular structure organization GO:0045995 regulation of embryonic development |
Molecular Function | - |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix GO:0005604 basement membrane GO:0005605 basal lamina GO:0005610 laminin-5 complex GO:0043256 laminin complex GO:0044420 extracellular matrix component |
KEGG |
hsa04151 PI3K-Akt signaling pathway hsa04510 Focal adhesion hsa04512 ECM-receptor interaction hsa01100 Metabolic pathways |
Reactome |
R-HSA-2214320: Anchoring fibril formation R-HSA-2022090: Assembly of collagen fibrils and other multimeric structures R-HSA-446728: Cell junction organization R-HSA-1500931: Cell-Cell communication R-HSA-1474290: Collagen formation R-HSA-1474228: Degradation of the extracellular matrix R-HSA-3000178: ECM proteoglycans R-HSA-1474244: Extracellular matrix organization R-HSA-3000157: Laminin interactions R-HSA-8874081: MET activates PTK2 signaling R-HSA-8875878: MET promotes cell motility R-HSA-3000171: Non-integrin membrane-ECM interactions R-HSA-162582: Signal Transduction R-HSA-6806834: Signaling by MET R-HSA-446107: Type I hemidesmosome assembly |
Summary | |
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Symbol | LAMA3 |
Name | laminin, alpha 3 |
Aliases | nicein-150kDa; kalinin-165kDa; BM600-150kDa; epiligrin; LAMNA; laminin, alpha 3 (nicein (150kD), kalinin (16 ...... |
Chromosomal Location | 18q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between LAMA3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | LAMA3 |
Name | laminin, alpha 3 |
Aliases | nicein-150kDa; kalinin-165kDa; BM600-150kDa; epiligrin; LAMNA; laminin, alpha 3 (nicein (150kD), kalinin (16 ...... |
Chromosomal Location | 18q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of LAMA3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | LAMA3 |
Name | laminin, alpha 3 |
Aliases | nicein-150kDa; kalinin-165kDa; BM600-150kDa; epiligrin; LAMNA; laminin, alpha 3 (nicein (150kD), kalinin (16 ...... |
Chromosomal Location | 18q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of LAMA3 in various data sets.
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Points in the above scatter plot represent the mutation difference of LAMA3 in various data sets.
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Summary | |
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Symbol | LAMA3 |
Name | laminin, alpha 3 |
Aliases | nicein-150kDa; kalinin-165kDa; BM600-150kDa; epiligrin; LAMNA; laminin, alpha 3 (nicein (150kD), kalinin (16 ...... |
Chromosomal Location | 18q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of LAMA3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | LAMA3 |
Name | laminin, alpha 3 |
Aliases | nicein-150kDa; kalinin-165kDa; BM600-150kDa; epiligrin; LAMNA; laminin, alpha 3 (nicein (150kD), kalinin (16 ...... |
Chromosomal Location | 18q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of LAMA3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by LAMA3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | LAMA3 |
Name | laminin, alpha 3 |
Aliases | nicein-150kDa; kalinin-165kDa; BM600-150kDa; epiligrin; LAMNA; laminin, alpha 3 (nicein (150kD), kalinin (16 ...... |
Chromosomal Location | 18q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of LAMA3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | LAMA3 |
Name | laminin, alpha 3 |
Aliases | nicein-150kDa; kalinin-165kDa; BM600-150kDa; epiligrin; LAMNA; laminin, alpha 3 (nicein (150kD), kalinin (16 ...... |
Chromosomal Location | 18q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of LAMA3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | LAMA3 |
Name | laminin, alpha 3 |
Aliases | nicein-150kDa; kalinin-165kDa; BM600-150kDa; epiligrin; LAMNA; laminin, alpha 3 (nicein (150kD), kalinin (16 ...... |
Chromosomal Location | 18q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between LAMA3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | LAMA3 |
Name | laminin, alpha 3 |
Aliases | nicein-150kDa; kalinin-165kDa; BM600-150kDa; epiligrin; LAMNA; laminin, alpha 3 (nicein (150kD), kalinin (16 ...... |
Chromosomal Location | 18q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting LAMA3 collected from DrugBank database. |
Details on drugs targeting LAMA3.
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